C5ar1 complement component 5a receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C5ar1provided by MGI
Official Full Name: complement component 5a receptor 1provided by MGI
Primary source: MGI:MGI:88232
See related: Ensembl:ENSMUSG00000049130 AllianceGenome:MGI:88232
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C5aR; C5r1; Cd88; D7Msu1
Summary: Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 10.0), mammary gland adult (RPKM 8.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A2; 7 8.77 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15980668..15993465, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (16246743..16259540, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Title: C5a-C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms.
Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Title: Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2alpha-ATF4-CREB3L1 pathway.
Title: C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1 pathway.
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Title: Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer's mouse models.
Title: Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer's mouse models.
C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma.
Title: C5aR1 activation in mice controls inflammatory eosinophil recruitment and functions in allergic asthma.
Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis.
Title: Complement receptor C5aR1 on osteoblasts regulates osteoclastogenesis in experimental postmenopausal osteoporosis.
Pharmacological activation of the C5a receptor leads to stimulation of the beta-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Title: Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer's disease.
Effects of C5a and Receptor CD88 on Glutamate and N-Methyl-D-Aspartic Acid Receptor Expression in the Mouse Model of Optic Neuromyelitis.
Title: Effects of C5a and Receptor CD88 on Glutamate and N-Methyl-D-Aspartic Acid Receptor Expression in the Mouse Model of Optic Neuromyelitis.
Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells.
Title: Folic acid-mediated fibrosis is driven by C5a receptor 1-mediated activation of kidney myeloid cells.

Submit: New GeneRIF Correction See all GeneRIFs (141)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Endonuclease-mediated (9)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495464

D7Msu1 (e-PCR), detects polymorphism
- UniSTS:239021

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C5a binding	ISO Inferred from Sequence Orthology more info
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C5a receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables complement component C5a receptor activity	ISO Inferred from Sequence Orthology more info
enables complement receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in astrocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell proliferation in hindbrain	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in cognition	IGI Inferred from Genetic Interaction more info	PubMed
involved_in complement component C5a signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of tau-protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C5a anaphylatoxin chemotactic receptor 1

Names: C5a anaphylatoxin receptor; C5a ligand; C5a-R; complement component 5, receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001173550.1 → NP_001167021.1 C5a anaphylatoxin chemotactic receptor 1

See identical proteins and their annotated locations for NP_001167021.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.

Source sequence(s)

AC156630

Consensus CDS

CCDS20846.1

UniProtKB/Swiss-Prot

P30993, Q3TZ86

UniProtKB/TrEMBL

Q3UCS9

Related

ENSMUSP00000129972.2, ENSMUST00000168818.2

Conserved Domains (1) summary

pfam00001
Location:54 → 301

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_007577.4 → NP_031603.2 C5a anaphylatoxin chemotactic receptor 1

See identical proteins and their annotated locations for NP_031603.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) and variant 2 encode the same protein.

Source sequence(s)

AC156630, BB666123, BC125641

Consensus CDS

CCDS20846.1

UniProtKB/Swiss-Prot

P30993, Q3TZ86

UniProtKB/TrEMBL

Q3UCS9

Related

ENSMUSP00000060003.6, ENSMUST00000050770.6

Conserved Domains (1) summary

pfam00001
Location:54 → 301

7tm_1; 7 transmembrane receptor (rhodopsin family)