C3ar1 complement component 3a receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C3ar1provided by MGI
Official Full Name: complement component 3a receptor 1provided by MGI
Primary source: MGI:MGI:1097680
See related: Ensembl:ENSMUSG00000040552 AllianceGenome:MGI:1097680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AZ3B; C3AR; HNFAG09
Summary: Predicted to enable G protein-coupled receptor activity; complement component C3a binding activity; and complement component C3a receptor activity. Involved in positive regulation of angiogenesis; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including bladder; cerebral cortex; gut; male reproductive gland or organ; and skin. Human ortholog(s) of this gene implicated in asthma. Orthologous to human C3AR1 (complement C3a receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 5.2), mammary gland adult (RPKM 4.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F2; 6 57.93 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (122824099..122833116, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (122847140..122856157, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
Title: C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.
Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism.
Title: Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism.
Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Title: Deficiency of Complement C3a and C5a receptors Does Not Prevent Angiotensin II-Induced Hypertension and Hypertensive End-Organ Damage.
Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Title: Loss of C3a and C5a receptors promotes adipocyte browning and attenuates diet-induced obesity via activating inosine/A2aR pathway.
Complement C3aR depletion reverses HIF-1alpha-induced metabolic impairment and enhances microglial response to Abeta pathology.
Title: Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology.
Protective role for C3aR in experimental chronic pyelonephritis.
Title: Protective role for C3aR in experimental chronic pyelonephritis.
Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID.
Title: Complement C3a Receptor (C3aR) Mediates Vascular Dysfunction, Hippocampal Pathology, and Cognitive Impairment in a Mouse Model of VCID.
Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1beta concentrations and acute exacerbation of chronic obstructive pulmonary disease.
Title: Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1β concentrations and acute exacerbation of chronic obstructive pulmonary disease.
Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression.
Title: Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression.
C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models.
Title: C3aR Signaling Inhibits NK-cell Infiltration into the Tumor Microenvironment in Mouse Models.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Markers

C3ar1 (e-PCR), detects polymorphism
- UniSTS:164679

AF053757 (e-PCR)
- UniSTS:159569

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C3a binding	ISO Inferred from Sequence Orthology more info
enables complement component C3a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement component C3a receptor activity	ISO Inferred from Sequence Orthology more info
enables complement component C5a receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables complement receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within_positive_effect calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement receptor mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in tolerance induction to nonself antigen	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C3a anaphylatoxin chemotactic receptor

Names: C3a-R; anaphylatoxin C3a receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.