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Bub1b BUB1B, mitotic checkpoint serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 12236, updated on 9-Dec-2024

Summary

Official Symbol
Bub1bprovided by MGI
Official Full Name
BUB1B, mitotic checkpoint serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1333889
See related
Ensembl:ENSMUSG00000040084 AllianceGenome:MGI:1333889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BUBR1
Summary
Predicted to enable protein kinase activity. Acts upstream of or within metaphase/anaphase transition of mitotic cell cycle and protein localization to chromosome, centromeric region. Located in kinetochore. Part of outer kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study mosaic variegated aneuploidy syndrome 1. Human ortholog(s) of this gene implicated in colorectal cancer and mosaic variegated aneuploidy syndrome 1. Orthologous to human BUB1B (BUB1 mitotic checkpoint serine/threonine kinase B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E11.5 (RPKM 30.8), liver E14 (RPKM 21.6) and 14 other tissues See more
Orthologs
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Genomic context

See Bub1b in Genome Data Viewer
Location:
2 E5; 2 59.4 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118428684..118472073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118598202..118641592)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9526 Neighboring gene STARR-positive B cell enhancer mm9_chr2:118372239-118372540 Neighboring gene STARR-positive B cell enhancer ABC_E1250 Neighboring gene BCL2 modifying factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:118380077-118380314 Neighboring gene STARR-positive B cell enhancer ABC_E5963 Neighboring gene STARR-positive B cell enhancer ABC_E9527 Neighboring gene STARR-positive B cell enhancer ABC_E8791 Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene STARR-seq mESC enhancer starr_05463 Neighboring gene STARR-seq mESC enhancer starr_05464 Neighboring gene STARR-seq mESC enhancer starr_05465 Neighboring gene STARR-seq mESC enhancer starr_05466 Neighboring gene STARR-seq mESC enhancer starr_05467 Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene STARR-positive B cell enhancer ABC_E5965 Neighboring gene ankyrin repeat domain 63

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC36092

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables ribosomal protein S6 kinase activity  
Component Evidence Code Pubs
located_in cytoplasm  
located_in cytoplasm  
located_in cytosol  
located_in cytosol  
is_active_in kinetochore  
located_in kinetochore PubMed 
located_in kinetochore PubMed 
colocalizes_with kinetochore  
located_in kinetochore  
colocalizes_with kinetochore  
part_of mitotic checkpoint complex  
is_active_in nucleus  
part_of outer kinetochore PubMed 
part_of outer kinetochore  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in spindle  
located_in spindle  

General protein information

Preferred Names
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Names
MAD3/BUB1-related protein kinase
budding uninhibited by benzimidazoles 1 beta
budding uninhibited by benzimidazoles 1 homolog, beta
mitotic checkpoint kinase MAD3L
NP_033903.2
XP_006498685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009773.3NP_033903.2  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

    See identical proteins and their annotated locations for NP_033903.2

    Status: VALIDATED

    Source sequence(s)
    AK133909, AV315589, BU054510, BY013487
    Consensus CDS
    CCDS16579.1
    UniProtKB/Swiss-Prot
    A2ARS1, Q9Z1S0
    UniProtKB/TrEMBL
    Q3UZD6
    Related
    ENSMUSP00000037126.8, ENSMUST00000038341.8
    Conserved Domains (3) summary
    COG0515
    Location:825909
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam08311
    Location:51172
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7391035
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118428684..118472073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498622.4XP_006498685.1  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1

    UniProtKB/TrEMBL
    Q3UZD6
    Conserved Domains (3) summary
    TIGR01645
    Location:253445
    half-pint; poly-U binding splicing factor, half-pint family
    pfam08311
    Location:51172
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7401036
    PKc_like; Protein Kinases, catalytic domain
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