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Btn1a1 butyrophilin, subfamily 1, member A1 [ Mus musculus (house mouse) ]

Gene ID: 12231, updated on 5-Mar-2024

Summary

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Official Symbol
Btn1a1provided by MGI
Official Full Name
butyrophilin, subfamily 1, member A1provided by MGI
Primary source
MGI:MGI:103118
See related
Ensembl:ENSMUSG00000000706 AllianceGenome:MGI:103118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Btn
Summary
Predicted to enable signaling receptor binding activity. Involved in negative regulation of activated T cell proliferation and negative regulation of cytokine production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in genitourinary system and heart valve. Orthologous to human BTN1A1 (butyrophilin subfamily 1 member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 3.3), liver E14.5 (RPKM 1.1) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 9.72 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23641154..23650084, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23456984..23465914, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11534 Neighboring gene nuclear encoded tRNA threonine 6 (anticodon AGT) Neighboring gene STARR-positive B cell enhancer ABC_E11535 Neighboring gene nuclear encoded tRNA leucine 10 (anticodon CAG) Neighboring gene nuclear encoded tRNA glutamic acid 5 (anticodon TTC) Neighboring gene predicted gene, 52036 Neighboring gene nuclear encoded tRNA tyrosine 8 (anticodon GTA) Neighboring gene butyrophilin, subfamily 2, member A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Ogg SL, et al. Proc Natl Acad Sci U S A, 2004 Jul 6. PMID 15226505, Free PMC Article
  2. Structural organization and mammary-specific expression of the butyrophilin gene. Ogg SL, et al. Mamm Genome, 1996 Dec. PMID 8995761
  3. The butyrophilin 1a1 knockout mouse revisited: Ablation of Btn1a1 leads to concurrent cell death and renewal in the mammary epithelium during lactation. Jeong J, et al. FASEB Bioadv, 2021 Dec. PMID 34938960, Free PMC Article
  4. Restriction fragment length polymorphism in amplification products of the bovine butyrophilin gene: assignment of bovine butyrophilin to bovine chromosome 23. Taylor C, et al. Anim Genet, 1996 Jun. PMID 8759118
  5. Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane. Ishii T, et al. Biochim Biophys Acta, 1995 Dec 14. PMID 8541302

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data illustrated the importance of Akt1 in mammary epithelial cell proliferation, as well as in the regulation of Btn1a1 and subsequent expression of ss-casein.
    Title: Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
  2. These data are consistent with a coinhibitory role for mouse Butyrophilins
    Title: BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.
  3. PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase
    Title: The PRY/SPRY/B30.2 domain of butyrophilin 1A1 (BTN1A1) binds to xanthine oxidoreductase: implications for the function of BTN1A1 in the mammary gland and other tissues.
  4. expression of Btn1a1 is essential for the regulated secretion of milk-lipid droplets.
    Title: Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of activated T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
butyrophilin subfamily 1 member A1
Names
BT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013483.3 → NP_038511.1  butyrophilin subfamily 1 member A1 precursor

    See identical proteins and their annotated locations for NP_038511.1

    Status: VALIDATED

    Source sequence(s)
    AK142596, AK145168, AL714025, BE199598
    Consensus CDS
    CCDS26339.1
    UniProtKB/Swiss-Prot
    P97392, Q62556, Q8K2H7, Q921K7
    UniProtKB/TrEMBL
    Q3UM26, Q3UQC0
    Related
    ENSMUSP00000041013.8, ENSMUST00000041674.14
    Conserved Domains (3) summary
    smart00410
    Location:36 → 142
    IG_like; Immunoglobulin like
    cd15819
    Location:304 → 474
    SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
    cl11960
    Location:44 → 143
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23641154..23650084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516535.1 → XP_006516598.1  butyrophilin subfamily 1 member A1 isoform X1

    See identical proteins and their annotated locations for XP_006516598.1

    UniProtKB/TrEMBL
    Q3UM26
    Conserved Domains (2) summary
    cd15819
    Location:303 → 473
    SPRY_PRY_BTN1_2; butyrophilin subfamily member A1 and A2 (BTN1A and BTN2A)
    cl11960
    Location:43 → 142
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62556.2 GenPept UniProtKB/Swiss-Prot:Q62556

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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