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Btg3 BTG anti-proliferation factor 3 [ Mus musculus (house mouse) ]

Gene ID: 12228, updated on 18-Apr-2024

Summary

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Official Symbol
Btg3provided by MGI
Official Full Name
BTG anti-proliferation factor 3provided by MGI
Primary source
MGI:MGI:109532
See related
Ensembl:ENSMUSG00000022863 AllianceGenome:MGI:109532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ANA; tob5
Summary
This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]
Expression
Broad expression in genital fat pad adult (RPKM 36.7), placenta adult (RPKM 14.6) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.1; 16 45.36 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (78156748..78174069, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (78359860..78377181, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E330011O21 gene Neighboring gene coxsackie virus and adenovirus receptor Neighboring gene predicted gene, 25038 Neighboring gene STARR-positive B cell enhancer ABC_E5553 Neighboring gene STARR-seq mESC enhancer starr_41307 Neighboring gene STARR-seq mESC enhancer starr_41309 Neighboring gene STARR-positive B cell enhancer ABC_E9935 Neighboring gene STARR-seq mESC enhancer starr_41310 Neighboring gene DNA segment, Chr 16, ERATO Doi 472, expressed Neighboring gene RIKEN cDNA 4930478L05 gene Neighboring gene STARR-positive B cell enhancer ABC_E4183 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:78560476-78560629 Neighboring gene STARR-positive B cell enhancer mm9_chr16:78564961-78565261

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events. Miyai K, et al. J Biol Chem, 2009 Apr 17. PMID 19234306, Free PMC Article
  2. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Yoneda M, et al. Cancer Sci, 2009 Feb. PMID 19068083
  3. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. Cheng YC, et al. Cell Death Dis, 2020 Dec 11. PMID 33311481, Free PMC Article
  4. The mammalian anti-proliferative BTG/Tob protein family. Winkler GS. J Cell Physiol, 2010 Jan. PMID 19746446
  5. Expression of rat BTG(3) gene, Rbtg3, is regulated by redox changes. Seo MS, et al. Gene, 1999 Nov 15. PMID 10564823

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
    Title: Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation.
  2. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
    Title: Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma.
  3. Results suggest that ANA is a suppressor of ectopic bone formation induced by bone morphogenetic proteins, and this inhibitory ANA activity is a part of the negative feedback regulation of BMP function.
    Title: ANA deficiency enhances bone morphogenetic protein-induced ectopic bone formation via transcriptional events.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein BTG3
Names
B cell translocation gene 3
BTG family member 3
abundant in neuroepithelium area protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297747.1 → NP_001284676.1  protein BTG3

    See identical proteins and their annotated locations for NP_001284676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC130844
    Consensus CDS
    CCDS28277.1
    UniProtKB/Swiss-Prot
    P50615, Q62328
    UniProtKB/TrEMBL
    Q52L83
    Conserved Domains (1) summary
    smart00099
    Location:1 → 108
    btg1; tob/btg1 family

  2. NM_009770.3 → NP_033900.1  protein BTG3

    See identical proteins and their annotated locations for NP_033900.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC130844, AK144415, CK623612
    Consensus CDS
    CCDS28277.1
    UniProtKB/Swiss-Prot
    P50615, Q62328
    UniProtKB/TrEMBL
    Q52L83
    Related
    ENSMUSP00000023570.8, ENSMUST00000023570.14
    Conserved Domains (1) summary
    smart00099
    Location:1 → 108
    btg1; tob/btg1 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    78156748..78174069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50615.1 GenPept UniProtKB/Swiss-Prot:P50615

Gene LinkOut

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