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SPACA7 sperm acrosome associated 7 [ Homo sapiens (human) ]

Gene ID: 122258, updated on 3-Apr-2024

Summary

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Official Symbol
SPACA7provided by HGNC
Official Full Name
sperm acrosome associated 7provided by HGNC
Primary source
HGNC:HGNC:29575
See related
Ensembl:ENSG00000153498 AllianceGenome:HGNC:29575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf28
Summary
Predicted to act upstream of or within negative regulation of cell adhesion and single fertilization. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 19.1) See more
Orthologs
mouse all
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Genomic context

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Location:
13q34
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (112376355..112434689)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (111623523..111681824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (113030669..113089003)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903250 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr13:113000836-113001624 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113004827-113005327 Neighboring gene uncharacterized LOC105370373 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:113032121-113033320 Neighboring gene uncharacterized LOC105370372 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:113046012-113046542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113161934-113162852 Neighboring gene tubulin gamma complex component 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113233725-113234278 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5529 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5531 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113242463-113243282 Neighboring gene uncharacterized LOC124903251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5533 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113271950-113272450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113279517-113280017 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:113291197-113291866 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:113296973-113297156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:113302064-113302958 Neighboring gene ATP11A upstream neighbor lncRNA Neighboring gene Sharpr-MPRA regulatory region 9322

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a new mouse sperm acrosome-associated protein. Korfanty J, et al. Reproduction, 2012 Jun. PMID 22495889
  2. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
  3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article
  4. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
  5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ27356

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in acrosomal lumen IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sperm acrosome-associated protein 7
Names
protein SPACA7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145248.5 → NP_660291.2  sperm acrosome-associated protein 7 precursor

    See identical proteins and their annotated locations for NP_660291.2

    Status: VALIDATED

    Source sequence(s)
    AI219896, AL160033, BC016750
    Consensus CDS
    CCDS9524.1
    UniProtKB/Swiss-Prot
    Q5T8L1, Q96KW9
    Related
    ENSP00000283550.3, ENST00000283550.8
    Conserved Domains (1) summary
    pfam15307
    Location:19 → 125
    SPACA7; Sperm acrosome-associated protein 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    112376355..112434689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537468.3 → XP_011535770.1  sperm acrosome-associated protein 7 isoform X3

    See identical proteins and their annotated locations for XP_011535770.1

    Conserved Domains (1) summary
    pfam15307
    Location:12 → 111
    SPACA7; Sperm acrosome-associated protein 7

  2. XM_017020392.2 → XP_016875881.1  sperm acrosome-associated protein 7 isoform X8

  3. XM_011537471.3 → XP_011535773.1  sperm acrosome-associated protein 7 isoform X4

    See identical proteins and their annotated locations for XP_011535773.1

    Conserved Domains (1) summary
    pfam15307
    Location:1 → 80
    SPACA7; Sperm acrosome-associated protein 7

  4. XM_011537466.2 → XP_011535768.2  sperm acrosome-associated protein 7 isoform X1

  5. XM_011537472.3 → XP_011535774.2  sperm acrosome-associated protein 7 isoform X5

  6. XM_011537467.3 → XP_011535769.2  sperm acrosome-associated protein 7 isoform X2

  7. XM_024449318.2 → XP_024305086.2  sperm acrosome-associated protein 7 isoform X6

  8. XM_017020391.2 → XP_016875880.2  sperm acrosome-associated protein 7 isoform X7

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187592.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    177325..235659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328941.1 → XP_054184916.1  sperm acrosome-associated protein 7 isoform X3

  2. XM_054328946.1 → XP_054184921.1  sperm acrosome-associated protein 7 isoform X8

  3. XM_054328942.1 → XP_054184917.1  sperm acrosome-associated protein 7 isoform X4

  4. XM_054328939.1 → XP_054184914.1  sperm acrosome-associated protein 7 isoform X1

  5. XM_054328943.1 → XP_054184918.1  sperm acrosome-associated protein 7 isoform X5

  6. XM_054328940.1 → XP_054184915.1  sperm acrosome-associated protein 7 isoform X2

  7. XM_054328944.1 → XP_054184919.1  sperm acrosome-associated protein 7 isoform X6

  8. XM_054328945.1 → XP_054184920.1  sperm acrosome-associated protein 7 isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    111623523..111681824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374108.1 → XP_054230083.1  sperm acrosome-associated protein 7 isoform X3

  2. XM_054374113.1 → XP_054230088.1  sperm acrosome-associated protein 7 isoform X8

  3. XM_054374109.1 → XP_054230084.1  sperm acrosome-associated protein 7 isoform X4

  4. XM_054374106.1 → XP_054230081.1  sperm acrosome-associated protein 7 isoform X1

  5. XM_054374110.1 → XP_054230085.1  sperm acrosome-associated protein 7 isoform X5

  6. XM_054374107.1 → XP_054230082.1  sperm acrosome-associated protein 7 isoform X2

  7. XM_054374111.1 → XP_054230086.1  sperm acrosome-associated protein 7 isoform X6

  8. XM_054374112.1 → XP_054230087.1  sperm acrosome-associated protein 7 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KW9.2 GenPept UniProtKB/Swiss-Prot:Q96KW9

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