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TEX26 testis expressed 26 [ Homo sapiens (human) ]

Gene ID: 122046, updated on 5-Mar-2024

Summary

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Official Symbol
TEX26provided by HGNC
Official Full Name
testis expressed 26provided by HGNC
Primary source
HGNC:HGNC:28622
See related
Ensembl:ENSG00000175664 AllianceGenome:HGNC:28622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C13orf26
Summary
Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 7.9) See more
Orthologs
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Genomic context

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Location:
13q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (30932656..30975500)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (30154575..30197390)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31506793..31549637)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr13:31459446-31460017 Neighboring gene long intergenic non-protein coding RNA 545 Neighboring gene TEX26 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31481009-31481510 Neighboring gene mesenteric estrogen dependent adipogenesis Neighboring gene uncharacterized LOC105370145 Neighboring gene NANOG hESC enhancer GRCh37_chr13:31557478-31558053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31578926-31579456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31579457-31579987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7548 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:31619425-31620624 Neighboring gene uncharacterized LOC124903147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31620925-31621454 Neighboring gene uncharacterized LOC102723392 Neighboring gene Sharpr-MPRA regulatory region 1526

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of a large set of rare complete human knockouts. Sulem P, et al. Nat Genet, 2015 May. PMID 25807282
  2. Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes. Rausell A, et al. Proc Natl Acad Sci U S A, 2020 Jun 16. PMID 32487729, Free PMC Article
  3. The mutational constraint spectrum quantified from variation in 141,456 humans. Karczewski KJ, et al. Nature, 2020 May. PMID 32461654, Free PMC Article
  4. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-03)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-03)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Clone Names

  • MGC40178

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testis-expressed protein 26
Names
testis-expressed sequence 26 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353388.2 → NP_001340317.1  testis-expressed protein 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL353680

  2. NM_001353389.2 → NP_001340318.1  testis-expressed protein 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL353680

  3. NM_001353390.2 → NP_001340319.1  testis-expressed protein 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL353680

  4. NM_001353391.2 → NP_001340320.1  testis-expressed protein 26 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, 4, and 5 all encode the same isoform (b).
    Source sequence(s)
    AL353680

  5. NM_152325.3 → NP_689538.1  testis-expressed protein 26 isoform a

    See identical proteins and their annotated locations for NP_689538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL353680, BC030277
    Consensus CDS
    CCDS9339.1
    UniProtKB/Swiss-Prot
    Q8N6G2
    Related
    ENSP00000369840.3, ENST00000380473.8

RNA

  1. NR_148425.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks three exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL353680

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    30932656..30975500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047430094.1 → XP_047286050.1  testis-expressed protein 26 isoform X3

  2. XM_011534925.4 → XP_011533227.1  testis-expressed protein 26 isoform X5

  3. XM_011534926.4 → XP_011533228.1  testis-expressed protein 26 isoform X6

  4. XM_011534919.4 → XP_011533221.1  testis-expressed protein 26 isoform X1

  5. XM_011534924.4 → XP_011533226.1  testis-expressed protein 26 isoform X4

  6. XM_011534921.4 → XP_011533223.1  testis-expressed protein 26 isoform X2

  7. XM_011534927.4 → XP_011533229.1  testis-expressed protein 26 isoform X7

RNA

  1. XR_001749479.3 RNA Sequence

  2. XR_941493.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    30154575..30197390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374101.1 → XP_054230076.1  testis-expressed protein 26 isoform X3

  2. XM_054374103.1 → XP_054230078.1  testis-expressed protein 26 isoform X5

  3. XM_054374104.1 → XP_054230079.1  testis-expressed protein 26 isoform X6

  4. XM_054374099.1 → XP_054230074.1  testis-expressed protein 26 isoform X1

  5. XM_054374102.1 → XP_054230077.1  testis-expressed protein 26 isoform X4

  6. XM_054374100.1 → XP_054230075.1  testis-expressed protein 26 isoform X2

  7. XM_054374105.1 → XP_054230080.1  testis-expressed protein 26 isoform X7

RNA

  1. XR_008488731.1 RNA Sequence

  2. XR_008488732.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N6G2.1 GenPept UniProtKB/Swiss-Prot:Q8N6G2

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