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Bop1 block of proliferation 1 [ Mus musculus (house mouse) ]

Gene ID: 12181, updated on 5-Mar-2024

Summary

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Official Symbol
Bop1provided by MGI
Official Full Name
block of proliferation 1provided by MGI
Primary source
MGI:MGI:1334460
See related
Ensembl:ENSMUSG00000022557 AllianceGenome:MGI:1334460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Erb1p; Kiaa0124; mKIAA0124
Summary
Enables ribonucleoprotein complex binding activity. Involved in cell population proliferation and cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Acts upstream of or within rRNA processing and ribosomal large subunit biogenesis. Located in nucleolus. Is expressed in several structures, including female reproductive system and urinary system. Orthologous to human BOP1 (BOP1 ribosomal biogenesis factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 54.9), thymus adult (RPKM 50.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 35.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76337188..76361449, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76452988..76477249, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1912 Neighboring gene testis-specific serine kinase 5 Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene scleraxis scleraxis bHLH transcription factor Neighboring gene STARR-positive B cell enhancer ABC_E5490 Neighboring gene heat shock factor 1 Neighboring gene diacylglycerol O-acyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway. Gupta R, et al. Proc Natl Acad Sci U S A, 2019 Mar 5. PMID 30782837, Free PMC Article
  2. Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. Strezoska Z, et al. J Biol Chem, 2002 Aug 16. PMID 12048210
  3. Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Strezoska Z, et al. Mol Cell Biol, 2000 Aug. PMID 10891491, Free PMC Article
  4. Isolation of growth suppressors from a cDNA expression library. Pestov DG, et al. Oncogene, 1998 Dec 17. PMID 9872334
  5. New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals. Qi J, et al. Gut, 2016 Oct. PMID 26156959

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
    Title: BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
  2. PDGF-C promotes cell proliferation partially via downregulating BOP1.
    Title: PDGF-C promotes cell proliferation partially via downregulating BOP1.
  3. BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
    Title: BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.
  4. BOP1 knockdown promoted down-regulation of the MAPK phosphatases DUSP4 and DUSP6 via a transcription-based mechanism, leading to increased MAPK signaling.
    Title: Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway.
  5. New direct Wnt/beta-catenin target gene Bop1, which induced epithelial-mesenchymal transition, cell migration and experimental metastasis of Colorectal cancer cells was identified.
    Title: New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.
  6. Murine fibroblasts expressing Scx mRNA from an exogenous Scx mini-gene indicated that the accumulation of Bop1 intronic RNA impairs the Scx gene expression in a trans-acting manner, which resulted in the reduction of the Scx mRNA level.
    Title: Estrogen down-regulation of the Scx gene is mediated by the opposing strand-overlapping gene Bop1.
  7. inactivation of inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression
    Title: Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression.
  8. Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex).
    Title: Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.
  9. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association.
    Title: Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rRNA processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosomal large subunit assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PeBoW complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
ribosome biogenesis protein BOP1
Names
block of proliferation 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013481.2 → NP_038509.1  ribosome biogenesis protein BOP1

    See identical proteins and their annotated locations for NP_038509.1

    Status: VALIDATED

    Source sequence(s)
    AK079627, AV349722
    Consensus CDS
    CCDS27570.1
    UniProtKB/Swiss-Prot
    P97452, Q3TK87, Q6ZQI9, Q91X31
    UniProtKB/TrEMBL
    Q3TJZ5
    Related
    ENSMUSP00000023217.10, ENSMUST00000023217.11
    Conserved Domains (4) summary
    COG2319
    Location:395 → 732
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:394 → 732
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam08145
    Location:130 → 388
    BOP1NT; BOP1NT (NUC169) domain
    sd00039
    Location:403 → 441
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76337188..76361449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159096.1 → XP_036014989.1  ribosome biogenesis protein BOP1 isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:233 → 571
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:242 → 280
    7WD40; WD40 repeat [structural motif]
    pfam08145
    Location:1 → 227
    BOP1NT; BOP1NT (NUC169) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97452.1 GenPept UniProtKB/Swiss-Prot:P97452

Gene LinkOut

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