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Bmx BMX non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 12169, updated on 21-Apr-2024

Summary

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Official Symbol
Bmxprovided by MGI
Official Full Name
BMX non-receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1101778
See related
Ensembl:ENSMUSG00000031377 AllianceGenome:MGI:1101778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etk; Tyro8; Etk/Bmx
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within apoptotic process; cell adhesion; and phosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Is expressed in several structures, including cardiovascular system; central nervous system; immune system; lung; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM 0.9) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F5; X 76.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162975838..163041189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164192842..164258193, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2 Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene predicted gene, 57673 Neighboring gene pirin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling. Holopainen T, et al. Proc Natl Acad Sci U S A, 2015 Oct 20. PMID 26430242, Free PMC Article
  2. Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases. Chen S, et al. Sci Signal, 2013 May 28. PMID 23716717, Free PMC Article
  3. Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy. Mitchell-Jordan SA, et al. Circ Res, 2008 Dec 5. PMID 18988895, Free PMC Article
  4. Bmx tyrosine kinase transgene induces skin hyperplasia, inflammatory angiogenesis, and accelerated wound healing. Paavonen K, et al. Mol Biol Cell, 2004 Sep. PMID 15229285, Free PMC Article
  5. Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Holopainen T, et al. Cancer Res, 2012 Jul 15. PMID 22593188

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
    Title: Fas signaling in adipocytes promotes low-grade inflammation and lung metastasis of colorectal cancer through interaction with Bmx.
  2. Data show that bone marrow kinase on the X chromosome (BMX) specifically repressed thrombin-PAR1 (protease-activated receptor-1) signaling in endothelial cells by directly phosphorylating PAR1 and promoting its internalization and deactivation.
    Title: BMX Represses Thrombin-PAR1-Mediated Endothelial Permeability and Vascular Leakage During Early Sepsis.
  3. results suggest that the endothelial Bmx tyrosine kinase could provide a target to attenuate the development of cardiac hypertrophy
    Title: Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling.
  4. Btk, Tec, Bmx are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
    Title: The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages.
  5. Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
    Title: Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases.
  6. Our findings therefore indicate that Bmx activity contributes to tumor angiogenesis and growth.
    Title: Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.
  7. genetic ablation of BMX conferred protection in arthritis model confirming BMX an essential mediator of inflammation in vivo; conclude BMX an essential component of inflammatory cytokine signaling and catalytic as well noncatalytic functions are involved
    Title: The tyrosine kinase BMX is an essential mediator of inflammatory arthritis in a kinase-independent manner.
  8. Investigate Bmx mediates VEGF-dependent lymphangiogenic signaling.
    Title: Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis.
  9. by preventing binding of Etk/Bmx to PAR(1) -C-tail, hPar1 oncogenic properties are abrogated
    Title: Etk/Bmx regulates proteinase-activated-receptor1 (PAR1) in breast cancer invasion: signaling partners, hierarchy and physiological significance.
  10. activation of Etk largely co-localizes with TNFR2 in vascular endothelial cells and cardiomyocytes.
    Title: TNF receptors differentially signal and are differentially expressed and regulated in the human heart.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoplasmic tyrosine-protein kinase BMX
Names
TYRO8 protein tyrosine kinase 8
bone marrow tyrosine kinase gene in chromosome X protein homolog
NP_033889.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009759.4 → NP_033889.2  cytoplasmic tyrosine-protein kinase BMX

    Status: VALIDATED

    Source sequence(s)
    AK036707, AK040936
    Consensus CDS
    CCDS30519.2
    UniProtKB/Swiss-Prot
    P97504
    UniProtKB/TrEMBL
    B1AUL5, B1AUL6
    Related
    ENSMUSP00000107884.3, ENSMUST00000112265.9
    Conserved Domains (5) summary
    cd10399
    Location:269 → 374
    SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
    cd01238
    Location:25 → 151
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:27 → 115
    PH; PH domain
    pfam07714
    Location:397 → 646
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:392 → 647
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162975838..163041189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97504.1 GenPept UniProtKB/Swiss-Prot:P97504

Gene LinkOut

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