Bmp6 bone morphogenetic protein 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmp6provided by MGI
Official Full Name: bone morphogenetic protein 6provided by MGI
Primary source: MGI:MGI:88182
See related: Ensembl:ENSMUSG00000039004 AllianceGenome:MGI:88182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vgr1; D13Wsu115e
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]
Expression: Biased expression in lung adult (RPKM 52.0), kidney adult (RPKM 13.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 18.15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (38529098..38684283)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (38345716..38500314)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial infarction model by upregulating AP-1/CEMIP expression.
Title: BMP6 knockdown enhances cardiac fibrosis in a mouse myocardial infarction model by upregulating AP-1/CEMIP expression.
Runx3 regulates iron metabolism via modulation of BMP signalling.
Title: Runx3 regulates iron metabolism via modulation of BMP signalling.
BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
Title: BMP6/TAZ-Hippo signaling modulates angiogenesis and endothelial cell response to VEGF.
Iron overload in aging Bmp6(/) mice induces exocrine pancreatic injury and fibrosis due to acinar cell loss.
Title: Iron overload in aging Bmp6(‑/‑) mice induces exocrine pancreatic injury and fibrosis due to acinar cell loss.
Orphan Nuclear Receptor ERRgamma Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice.
Title: Orphan Nuclear Receptor ERRγ Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice.
Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling.
Title: Copresentation of BMP-6 and RGD Ligands Enhances Cell Adhesion and BMP-Mediated Signaling.
In vivo model of bleomycin-induced dermal fibrosis showed significantly enhanced fibrosis in Bmp6-deficient mice compared with wild-type mice. Conversely, application of recombinant BMP6 significantly ameliorated dermal fibrosis and herewith provided proof of concept for the successful treatment of this fibrotic skin disease.
Title: Bone Morphogenetic Protein-6 Inhibits Fibrogenesis in Scleroderma Offering Treatment Options for Fibrotic Skin Disease.
Reduced miR-451a expression enhances bone formation during the progression of osteoporosis, which might be at least partly via the meditation of Bmp6 expression.
Title: Suppression of miR-451a accelerates osteogenic differentiation and inhibits bone loss via Bmp6 signaling during osteoporosis.
BMP6 is absolutely required for hepcidin regulation by serum iron.
Title: Iron, erythropoietin, and inflammation regulate hepcidin in Bmp2-deficient mice, but serum iron fails to induce hepcidin in Bmp6-deficient mice.
ERFE specifically abrogated the induction of hepcidin by BMP5, BMP6, and BMP7 but had little or no effect on hepcidin induction by BMP2, BMP4, BMP9, or activin B.
Title: Erythroferrone inhibits the induction of hepcidin by BMP6.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bmp6 (e-PCR), detects polymorphism
- UniSTS:496643

Bmp6 (e-PCR), detects polymorphism
- UniSTS:532295

Bmp6 (e-PCR), detects polymorphism
- UniSTS:480334

Bmp6 (e-PCR), detects polymorphism
- UniSTS:141182

Bmp6 (e-PCR), detects polymorphism
- UniSTS:141183

BE107569 (e-PCR)
- UniSTS:246922

RH125863 (e-PCR)
- UniSTS:141968

X80992 (e-PCR)
- UniSTS:163533

RH142158 (e-PCR)
- UniSTS:231413

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BMP receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to extracellular stimulus	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to iron ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in kidney development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within male genitalia development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organismal-level iron ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bone morphogenetic protein 6

Names: VG-1-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007556.4 → NP_031582.1 bone morphogenetic protein 6 preproprotein

See identical proteins and their annotated locations for NP_031582.1

Status: VALIDATED

Source sequence(s)

AC124549, AC154747

Consensus CDS

CCDS26462.1

UniProtKB/Swiss-Prot

B2RRV6, P20722

UniProtKB/TrEMBL

Q3UXB2

Related

ENSMUSP00000126999.2, ENSMUST00000171970.3

Conserved Domains (2) summary

smart00204
Location:409 → 510

TGFB; Transforming growth factor-beta (TGF-beta) family

pfam00688
Location:58 → 359

TGFb_propeptide; TGF-beta propeptide