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ZNF641 zinc finger protein 641 [ Homo sapiens (human) ]

Gene ID: 121274, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF641provided by HGNC
Official Full Name
zinc finger protein 641provided by HGNC
Primary source
HGNC:HGNC:31834
See related
Ensembl:ENSG00000167528 MIM:613906; AllianceGenome:HGNC:31834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 5.5), ovary (RPKM 3.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
12q13.11
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (48334587..48351246, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (48295893..48312553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48728370..48745029, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369753 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48723521-48724020 Neighboring gene H1.7 linker histone Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:48744721-48745457 Neighboring gene olfactory receptor family 5 subfamily BK member 1 pseudogene Neighboring gene olfactory receptor family 5 subfamily BT member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activation of transcriptional activities of AP-1 and SRE by a new zinc-finger protein ZNF641. Qi X, et al. Biochem Biophys Res Commun, 2006 Jan 27. PMID 16343441
  2. HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription. Yan H, et al. Biochem Biophys Res Commun, 2022 Jun 11. PMID 35427894
  3. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. Virok DP, et al. J Proteome Res, 2011 Apr 1. PMID 21244100
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. Weimann M, et al. Nat Methods, 2013 Apr. PMID 23455924
  5. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription.
    Title: HCG15 is a hypoxia-responsive lncRNA and facilitates hepatocellular carcinoma cell proliferation and invasion by enhancing ZNF641 transcription.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31295, DKFZp667D1012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 641

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172681.2 → NP_001166152.1  zinc finger protein 641 isoform 2

    See identical proteins and their annotated locations for NP_001166152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC024257, AY842285, BC018090
    Consensus CDS
    CCDS53788.1
    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000449974.1, ENST00000547026.6
    Conserved Domains (6) summary
    smart00349
    Location:95 → 156
    KRAB; krueppel associated box
    COG5048
    Location:337 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358 → 380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95 → 135
    KRAB; KRAB box
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001172682.2 → NP_001166153.1  zinc finger protein 641 isoform 3

    See identical proteins and their annotated locations for NP_001166153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternate transcription start site and 5' UTR, uses a downstream start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC024257, AK298064, DB445168
    Consensus CDS
    CCDS53787.1
    UniProtKB/Swiss-Prot
    Q96N77
    Related
    ENSP00000394627.3, ENST00000448928.7
    Conserved Domains (4) summary
    COG5048
    Location:328 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 280
    zf-H2C2_2; Zinc-finger double domain
    cl25431
    Location:2 → 90
    PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]

  3. NM_001365803.1 → NP_001352732.1  zinc finger protein 641 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC024257
    Consensus CDS
    CCDS53787.1
    Conserved Domains (4) summary
    COG5048
    Location:328 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:243 → 263
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:255 → 280
    zf-H2C2_2; Zinc-finger double domain
    cl25431
    Location:2 → 90
    PurL1; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]

  4. NM_001365804.1 → NP_001352733.1  zinc finger protein 641 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC024257
    Conserved Domains (2) summary
    PLN03206
    Location:2 → 90
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:95 → 156
    KRAB; krueppel associated box

  5. NM_001365805.1 → NP_001352734.1  zinc finger protein 641 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC024257, DA115635
    Conserved Domains (3) summary
    COG5048
    Location:194 → 273
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:109 → 129
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:121 → 146
    zf-H2C2_2; Zinc-finger double domain

  6. NM_152320.3 → NP_689533.2  zinc finger protein 641 isoform 1

    See identical proteins and their annotated locations for NP_689533.2

    Status: VALIDATED

    Source sequence(s)
    AC024257, AK055857
    Consensus CDS
    CCDS8763.1
    UniProtKB/Swiss-Prot
    B3KS43, B4DNU5, Q8TCQ7, Q8WVE1, Q96N77
    Related
    ENSP00000301042.3, ENST00000301042.7
    Conserved Domains (6) summary
    smart00349
    Location:109 → 170
    KRAB; krueppel associated box
    COG5048
    Location:351 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:266 → 286
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:372 → 394
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:109 → 149
    KRAB; KRAB box
    pfam13465
    Location:278 → 303
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    48334587..48351246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268640.6 → XP_005268697.1  zinc finger protein 641 isoform X4

    Conserved Domains (2) summary
    smart00349
    Location:109 → 170
    KRAB; krueppel associated box
    pfam01352
    Location:109 → 149
    KRAB; KRAB box

  2. XM_011537898.3 → XP_011536200.1  zinc finger protein 641 isoform X2

    See identical proteins and their annotated locations for XP_011536200.1

    UniProtKB/Swiss-Prot
    Q96N77
    Conserved Domains (6) summary
    smart00349
    Location:95 → 156
    KRAB; krueppel associated box
    COG5048
    Location:337 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358 → 380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95 → 135
    KRAB; KRAB box
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain

  3. XM_005268638.5 → XP_005268695.1  zinc finger protein 641 isoform X2

    See identical proteins and their annotated locations for XP_005268695.1

    UniProtKB/Swiss-Prot
    Q96N77
    Conserved Domains (6) summary
    smart00349
    Location:95 → 156
    KRAB; krueppel associated box
    COG5048
    Location:337 → 416
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:358 → 380
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:95 → 135
    KRAB; KRAB box
    pfam13465
    Location:264 → 289
    zf-H2C2_2; Zinc-finger double domain

  4. XM_005268637.4 → XP_005268694.1  zinc finger protein 641 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:342 → 421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:257 → 277
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:363 → 385
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:269 → 294
    zf-H2C2_2; Zinc-finger double domain

  5. XM_047428287.1 → XP_047284243.1  zinc finger protein 641 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    48295893..48312553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371076.1 → XP_054227051.1  zinc finger protein 641 isoform X4

  2. XM_054371073.1 → XP_054227048.1  zinc finger protein 641 isoform X2

  3. XM_054371074.1 → XP_054227049.1  zinc finger protein 641 isoform X2

  4. XM_054371072.1 → XP_054227047.1  zinc finger protein 641 isoform X1

  5. XM_054371075.1 → XP_054227050.1  zinc finger protein 641 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96N77.2 GenPept UniProtKB/Swiss-Prot:Q96N77

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