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Bik BCL2-interacting killer [ Mus musculus (house mouse) ]

Gene ID: 12124, updated on 5-Mar-2024

Summary

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Official Symbol
Bikprovided by MGI
Official Full Name
BCL2-interacting killerprovided by MGI
Primary source
MGI:MGI:1206591
See related
Ensembl:ENSMUSG00000016758 AllianceGenome:MGI:1206591
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Blk; Nbk; Biklk
Summary
Predicted to enable BH domain binding activity. Acts upstream of or within apoptotic mitochondrial changes; male gonad development; and spermatogenesis. Located in mitochondrial envelope. Is expressed in heart; liver; lung; metanephros; and testis. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 4.3), colon adult (RPKM 3.3) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 39.4 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83410992..83428836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83526790..83544635)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1 Neighboring gene predicted gene, 46495 Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene translocator protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice. Soni S, et al. Virol J, 2023 Apr 24. PMID 37095508, Free PMC Article
  2. Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins. Osterlund EJ, et al. J Biol Chem, 2023 Feb. PMID 36603764, Free PMC Article
  3. IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells. Chand HS, et al. Sci Rep, 2018 Jan 11. PMID 29323189, Free PMC Article
  4. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Lang JY, et al. Cancer Cell, 2011 Sep 13. PMID 21907925, Free PMC Article
  5. Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Sher YP, et al. Mol Cancer Ther, 2011 Apr. PMID 21282355

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bik promotes proteasomal degradation to control low-grade inflammation.
    Title: Bik promotes proteasomal degradation to control low-grade inflammation.
  2. Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females.
    Title: Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females.
  3. Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice.
    Title: Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice.
  4. Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.
    Title: Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.
  5. Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.
    Title: Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.
  6. These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins.
    Title: Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.
  7. OPN induces oxidative stress via the involvement of mitochondria and NOX-4. It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.
    Title: Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK.
  8. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
    Title: Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
  9. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
    Title: Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
  10. The Bik protein, even in combination with Noxa, is not a potent suppressor of c-Myc-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc-driven tumours.
    Title: Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH domain binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within male gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
bcl-2-interacting killer
Names
apoptosis inducer NBK
bik-like killer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007546.2 → NP_031572.1  bcl-2-interacting killer

    See identical proteins and their annotated locations for NP_031572.1

    Status: PROVISIONAL

    Source sequence(s)
    AL583889
    Consensus CDS
    CCDS27703.1
    UniProtKB/Swiss-Prot
    O70337
    UniProtKB/TrEMBL
    A0A2R8W6U8
    Related
    ENSMUSP00000016902.4, ENSMUST00000016902.5
    Conserved Domains (1) summary
    pfam12201
    Location:1 → 149
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83410992..83428836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520354.5 → XP_006520417.1  bcl-2-interacting killer isoform X2

    UniProtKB/TrEMBL
    Q99L97
    Conserved Domains (1) summary
    pfam12201
    Location:34 → 182
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

  2. XM_006520355.3 → XP_006520418.1  bcl-2-interacting killer isoform X3

    See identical proteins and their annotated locations for XP_006520418.1

    UniProtKB/Swiss-Prot
    O70337
    UniProtKB/TrEMBL
    A0A2R8W6U8
    Related
    ENSMUSP00000155439.2, ENSMUST00000229165.2
    Conserved Domains (1) summary
    pfam12201
    Location:1 → 149
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

  3. XM_006520356.2 → XP_006520419.1  bcl-2-interacting killer isoform X3

    See identical proteins and their annotated locations for XP_006520419.1

    UniProtKB/Swiss-Prot
    O70337
    UniProtKB/TrEMBL
    A0A2R8W6U8
    Conserved Domains (1) summary
    pfam12201
    Location:1 → 149
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing

  4. XM_006520353.4 → XP_006520416.1  bcl-2-interacting killer isoform X1

    Conserved Domains (1) summary
    pfam12201
    Location:60 → 208
    bcl-2I13; Bcl2-interacting killer, BH3-domain containing
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70337.1 GenPept UniProtKB/Swiss-Prot:O70337

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