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Bcat1 branched chain aminotransferase 1, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 12035, updated on 11-Apr-2024

Summary

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Official Symbol
Bcat1provided by MGI
Official Full Name
branched chain aminotransferase 1, cytosolicprovided by MGI
Primary source
MGI:MGI:104861
See related
Ensembl:ENSMUSG00000030268 AllianceGenome:MGI:104861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCATc; Eca39
Summary
Enables branched-chain-amino-acid transaminase activity. Acts upstream of or within branched-chain amino acid catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; craniocervical region bone; limb; nervous system; and sensory organ. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 2.3), ovary adult (RPKM 2.1) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Bcat1 in Genome Data Viewer
Location:
6 G3; 6 77.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (144939561..145021883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (144993835..145076157, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32124 Neighboring gene STARR-positive B cell enhancer mm9_chr6:144788652-144788953 Neighboring gene STARR-seq mESC enhancer starr_17760 Neighboring gene predicted gene, 20124 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:144851216-144851325 Neighboring gene STARR-positive B cell enhancer ABC_E10418 Neighboring gene STARR-seq mESC enhancer starr_17761 Neighboring gene predicted gene, 53314 Neighboring gene predicted gene, 46721 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:144969219-144969382 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 26666 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene predicted gene, 38925 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene predicted gene 15543 Neighboring gene dynein axonemal intermediate chain 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice. Tan L, et al. Biochem Biophys Res Commun, 2022 Nov 26. PMID 36182869
  2. BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism. Go M, et al. Exp Mol Med, 2022 Jun. PMID 35760874, Free PMC Article
  3. Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia. Ouyang H, et al. BMC Musculoskelet Disord, 2022 May 13. PMID 35562710, Free PMC Article
  4. Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling. Chen S, et al. Stem Cell Res, 2020 Dec. PMID 33271468
  5. BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs. Xin W, et al. Cell Death Dis, 2020 Sep 16. PMID 32938905, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
  2. Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2[-/-] tumor cell line.
    Title: Bcat1 is controlled by Tsc2/mTORC1 pathway at expression levels and its deficiency together with Bcat2 inactivation suppresses the growth of a Tsc2(-/-) tumor cell line.
  3. BCAT1 redox function maintains mitotic fidelity.
    Title: BCAT1 redox function maintains mitotic fidelity.
  4. The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
    Title: The proatherosclerotic function of BCAT1 in atherosclerosis development of aged-apolipoprotein E-deficient mice.
  5. BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism.
    Title: BCAT1 promotes osteoclast maturation by regulating branched-chain amino acid metabolism.
  6. Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
    Title: Impaired expression of BCAT1 relates to muscle atrophy of mouse model of sarcopenia.
  7. Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling.
    Title: Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling.
  8. BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs.
    Title: BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs.
  9. Global deletion of BCATm caused a dramatic build-up of branched-chain amino acids, which could not be utilised for energy or amino acid synthesis, ultimately delaying the growth of lymphoma tumours.
    Title: Mice deficient in the mitochondrial branched-chain aminotransferase (BCATm) respond with delayed tumour growth to a challenge with EL-4 lymphoma.
  10. regulatory role in macrophage function
    Title: BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-isoleucine transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-leucine transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-valine transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables branched-chain-amino-acid transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables branched-chain-amino-acid transaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within branched-chain amino acid catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branched-chain amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
branched-chain-amino-acid aminotransferase, cytosolic
Names
BCAT(c)
NP_001019639.1
NP_031558.3
XP_011239868.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024468.3 → NP_001019639.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_001019639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC140416, AK036309, AW491045
    Consensus CDS
    CCDS20691.1
    UniProtKB/TrEMBL
    Q8CBC8, Q9CXX6
    Related
    ENSMUSP00000032402.6, ENSMUST00000032402.12
    Conserved Domains (2) summary
    PRK13357
    Location:100 → 453
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:148 → 442
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

  2. NM_007532.5 → NP_031558.3  branched-chain-amino-acid aminotransferase, cytosolic isoform 2

    See identical proteins and their annotated locations for NP_031558.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and unique N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140416, AK167232, AW491045, BY781109
    Consensus CDS
    CCDS39703.1
    UniProtKB/Swiss-Prot
    P24288, Q7TMT2
    UniProtKB/TrEMBL
    Q3TJN1, Q9CXX6
    Related
    ENSMUSP00000107371.2, ENSMUST00000111742.8
    Conserved Domains (2) summary
    PRK13357
    Location:33 → 386
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:81 → 375
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    144939561..145021883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241566.3 → XP_011239868.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

    UniProtKB/TrEMBL
    Q9CXX6
    Conserved Domains (1) summary
    PRK13357
    Location:32 → 385
    PRK13357; branched-chain amino acid aminotransferase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24288.2 GenPept UniProtKB/Swiss-Prot:P24288

Gene LinkOut

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