U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TMEM45B transmembrane protein 45B [ Homo sapiens (human) ]

Gene ID: 120224, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TMEM45Bprovided by HGNC
Official Full Name
transmembrane protein 45Bprovided by HGNC
Primary source
HGNC:HGNC:25194
See related
Ensembl:ENSG00000151715 AllianceGenome:HGNC:25194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum (RPKM 57.4), small intestine (RPKM 54.1) and 9 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (129815848..129860003)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (129851489..129895715)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (129685743..129729898)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129619939-129620440 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:129620441-129620940 Neighboring gene uncharacterized LOC124902793 Neighboring gene Sharpr-MPRA regulatory region 8939 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:129673393-129673893 Neighboring gene TMEM45B-NFRKB intergenic CAGE-defined mid-level expression enhancer Neighboring gene ReSE screen-validated silencer GRCh37_chr11:129739277-129739466 Neighboring gene Sharpr-MPRA regulatory region 15352 Neighboring gene nuclear factor related to kappaB binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4067 Neighboring gene PR/SET domain 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4068 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129795831-129796332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:129806281-129806994 Neighboring gene MPRA-validated peak1509 silencer Neighboring gene Sharpr-MPRA regulatory region 3666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:129841453-129842000 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4069 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4070 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4072 Neighboring gene PRDM10 divergent transcript

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication. Yan F, et al. J Virol, 2022 Sep 14. PMID 35938871, Free PMC Article
  2. TMEM45B is a novel predictive biomarker for prostate cancer progression and metastasis. Luo F, et al. Neoplasma, 2018 Sep 19. PMID 30249106
  3. Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. Shen K, et al. Biomed Pharmacother, 2018 Aug. PMID 29803169
  4. Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells. Li Y, et al. Oncol Res, 2017 Jul 5. PMID 28244852, Free PMC Article
  5. TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells. Hu R, et al. Tumour Biol, 2016 Sep. PMID 27225290

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEMu45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
    Title: TMEΜ45B Interacts with Sindbis Virus Nsp1 and Nsp4 and Inhibits Viral Replication.
  2. increased expression of TMEM45B appears to be significantly associated with prostate carcinoma progression and metastasis
    Title: TMEM45B is a novel predictive biomarker for prostate cancer progression and metastasis.
  3. TMEM45B may be a new potent therapeutic molecule for the treatment of gastric cancer.
    Title: Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer.
  4. TMEM45B plays an important role in regulating the proliferation, migration, and invasion of osteosarcoma cells.
    Title: Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells.
  5. TMEM45B expression was significantly upregulated in pancreatic cancer tissues and cell lines. Moreover, TMEM45B was significantly positively correlated with the cell cycle and metastasis up pathways and regulated expression of proteins involved. This indicates an important role of TMEM45B in pancreatic cancer carcinogenesis.
    Title: TMEM45B promotes proliferation, invasion and migration and inhibits apoptosis in pancreatic cancer cells.
  6. Data show that transmembrane protein 45B (TMEM45B) was overexpressed in lung cancer and its expression correlated with overall survival of patients.
    Title: TMEM45B, up-regulated in human lung cancer, enhances tumorigenicity of lung cancer cells.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association search for type 2 diabetes genes in African Americans.
EBI GWAS Catalog
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ40787

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transmembrane protein 45B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331210.2 → NP_001318139.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AP003327, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117 → 234
    DUF716; Family of unknown function (DUF716)

  2. NM_001331211.2 → NP_001318140.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, AP003327, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
    Related
    ENSP00000436293.1, ENST00000524567.1
    Conserved Domains (1) summary
    pfam04819
    Location:117 → 234
    DUF716; Family of unknown function (DUF716)

  3. NM_001331212.2 → NP_001318141.1  transmembrane protein 45B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, AP003327, BM762740, BU607569, HY117153
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117 → 234
    DUF716; Family of unknown function (DUF716)

  4. NM_138788.5 → NP_620143.1  transmembrane protein 45B

    See identical proteins and their annotated locations for NP_620143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AK098106, AP003327, BU607569
    Consensus CDS
    CCDS8482.1
    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
    Related
    ENSP00000281441.3, ENST00000281441.8
    Conserved Domains (1) summary
    pfam04819
    Location:117 → 234
    DUF716; Family of unknown function (DUF716)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    129815848..129860003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426356.1 → XP_047282312.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  2. XM_047426354.1 → XP_047282310.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  3. XM_047426355.1 → XP_047282311.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  4. XM_017017188.2 → XP_016872677.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
    Conserved Domains (1) summary
    pfam04819
    Location:117 → 234
    DUF716; Family of unknown function (DUF716)

  5. XM_047426358.1 → XP_047282314.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  6. XM_047426357.1 → XP_047282313.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    129851489..129895715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367646.1 → XP_054223621.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  2. XM_054367648.1 → XP_054223623.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  3. XM_054367647.1 → XP_054223622.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  4. XM_054367651.1 → XP_054223626.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  5. XM_054367649.1 → XP_054223624.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21

  6. XM_054367650.1 → XP_054223625.1  transmembrane protein 45B isoform X1

    UniProtKB/Swiss-Prot
    A8K2L8, Q96B21
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96B21.1 GenPept UniProtKB/Swiss-Prot:Q96B21

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous