Pcdh15 protocadherin 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pcdh15provided by MGI
Official Full Name: protocadherin 15provided by MGI
Primary source: MGI:MGI:1891428
See related: Ensembl:ENSMUSG00000052613 AllianceGenome:MGI:1891428
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: av; roda; Ush1f; nmf19; Gm9815
Summary: Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception; and plasma membrane bounded cell projection organization. Located in several cellular components, including photoreceptor outer segment; plasma membrane; and stereocilium. Is expressed in several structures, including central nervous system; gut epithelium; metanephros; sensory organ; and vibrissa follicle. Used to study Usher syndrome type 1F and autosomal recessive nonsyndromic deafness 23. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 1.4), CNS E18 (RPKM 1.1) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B5.3; 10 37.43 cM

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (72932003..74485663)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (73096277..74649831)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Template-independent genome editing in the Pcdh15(av-3j) mouse, a model of human DFNB23 nonsyndromic deafness.
Title: Template-independent genome editing in the Pcdh15(av-3j) mouse, a model of human DFNB23 nonsyndromic deafness.
Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography.
Title: Molecular structures and conformations of protocadherin-15 and its complexes on stereocilia elucidated by cryo-electron tomography.
Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.
Title: Interaction of protocadherin-15 with the scaffold protein whirlin supports its anchoring of hair-bundle lateral links in cochlear hair cells.
Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15
Title: A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15.
LHFPL5 forms extensive interactions with the PCDH15 transmembrane helices and stabilizes the overall PCDH15-LHFPL5 assembly.
Title: Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
a modified ciliary transport pathway used for Pcdh15 transport into the cilium of the inner ear hair cell and coordinated by FGFR1 activity.
Title: FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia.
Many GABAergic interneurons, from their generation in the medial ganglionic eminence up to their settlement in the auditory cortex, express two cadherin-related (cdhr) proteins, cdhr23 and cdhr15, that form the hair bundle tip links gating the mechanoelectrical transduction channels.
Title: Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.
results demonstrate that alternative heterophilic tip-link structures form stable protein-protein interactions in vitro and suggest that homophilic PCDH15-PCDH15 tip links form through the interaction of additional EC repeats
Title: Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15.
interactions of wild type (WT) and mutant variants of N-terminal fragments (EC1+2) of cadherin-23 and protocadherin-15, two proteins essential for inner-ear mechanotransduction, are reported.
Title: Using thermal scanning assays to test protein-protein interactions of inner-ear cadherins.
data show that LHFPL5 is already present in the MET apparatus at P0 but requires PCDH15 at P3 to remain there. Shaft/ankle link localisation suggests it interacts with link proteins other than PCDH15
Title: Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (7) 1 citation
Transgenic (1) 1 citation
Targeted (6) 1 citation
Chemically induced (ENU) (7) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pcdh15 (e-PCR), detects polymorphism
- UniSTS:532117

BB078305 (e-PCR)
- UniSTS:185837

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within detection of mechanical stimulus involved in equilibrioception	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in equilibrioception	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell maintenance	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within righting reflex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of light stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sensory perception of sound	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within startle response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in stereocilium	EXP Inferred from Experiment more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protocadherin-15

Names: Ames waltzer; protocadherin 15 CD2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001142735.1 → NP_001136207.1 protocadherin-15 isoform CD1-2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (B) lacks an alternate in-frame exon in the 5' coding region, compared to variant A. The resulting isoform (CD1-2), also known as protocadherin-15-CD1 isoform 2, lacks a 5-aa segment near the N-terminus, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354396

Consensus CDS

CCDS56715.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000101064.4, ENSMUST00000105424.10

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142736.1 → NP_001136208.1 protocadherin-15 isoform CD1-4 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (C) lacks two alternate in-frame exons in the 5' and 3' coding region, compared to variant A. The resulting isoform (CD1-4), also known as protocadherin-15-CD1 isoform 4, lacks a 5-aa segment near the N-terminus and a 2-aa segment near the C-terminus, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354398

Consensus CDS

CCDS56718.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000122911.3, ENSMUST00000131321.9

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142737.1 → NP_001136209.1 protocadherin-15 isoform CD1-6 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (D) lacks an alternate in-frame exon in the 5' coding region and two alternate in-frame exons in the central coding region, compared to variant A. The resulting isoform (CD1-6), also known as protocadherin-15-CD1 isoform 6, lacks a 5-aa segment near the N-terminus and a 71-aa segment in the central protein, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354400

Consensus CDS

CCDS56719.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000101069.4, ENSMUST00000105429.10

Conserved Domains (1) summary

cd11304
Location:651 → 744

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142738.1 → NP_001136210.1 protocadherin-15 isoform CD1-8 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (F) lacks 4 alternate in-frame exons, compared to variant A. The resulting isoform (CD1-8), also known as protocadherin-15-CD1 isoform 8, has the same N- and C-termini but lacks four internal segments, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354401

Consensus CDS

CCDS48595.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000122940.3, ENSMUST00000147189.9

Conserved Domains (1) summary

cd11304
Location:685 → 778

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142739.1 → NP_001136211.1 protocadherin-15 isoform CD1-9 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (G) lacks two alternate in-frame exons in the 5' coding region, compared to variant A. The resulting isoform (CD1-9), also known as protocadherin-15-CD1 isoform 9, lacks a 27-aa segment near the N-terminus, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354402

Consensus CDS

CCDS56720.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000121939.3, ENSMUST00000126920.9

Conserved Domains (1) summary

cd11304
Location:700 → 793

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142740.1 → NP_001136212.1 protocadherin-15 isoform CD1-7 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (E) lacks three alternate in-frame exons, compared to variant A. The resulting isoform (CD1-7), also known as protocadherin-15-CD1 isoform 7, has the same N- and C-termini but lacks three internal segments, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354403

Consensus CDS

CCDS48594.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000090076.7, ENSMUST00000092420.13

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142741.1 → NP_001136213.1 protocadherin-15 isoform CD1-10 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (H) lacks three alternate in-frame exons, compared to variant A. The resulting isoform (CD1-10), also known as protocadherin-15-CD1 isoform 10, has the same N- and C-termini but lacks two internal segments, compared to isoform CD1-10.

Source sequence(s)

AC153858, AK139154, CJ166718, DQ354404

Consensus CDS

CCDS56721.1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000117731.3, ENSMUST00000129404.9

Conserved Domains (1) summary

cd11304
Location:700 → 793

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142742.1 → NP_001136214.1 protocadherin-15 isoform CD2-1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (I) includes an alternate in-frame exon in the central coding region and has a distinct 3' splice pattern, compared to variant A. The resulting isoform (CD2-1), also known as protocadherin-15-CD2 isoform 1, includes an alternate 7-aa segment in the central coding region and has a distinct and longer C-terminus, compared to isoform CD1-1.

Source sequence(s)

AK139154, CJ166718, DQ354405

Consensus CDS

CCDS56711.1

UniProtKB/TrEMBL

A0A0A6YY17

Related

ENSMUSP00000119662.3, ENSMUST00000151116.9

Conserved Domains (1) summary

cd11304
Location:734 → 827

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142743.1 → NP_001136215.1 protocadherin-15 isoform CD2-2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (J) lacks an alternate in-frame exon in the 5' coding region and has a distinct 3' splice pattern, compared to variant A. The resulting isoform (CD2-2), also known as protocadherin-15-CD2 isoform 2, lacks a 5-aa segment in the 5' coding region and has a distinct and longer C-terminus, compared to isoform CD1-1.

Source sequence(s)

AK139154, CJ166718, DQ354406

Consensus CDS

CCDS56716.1

UniProtKB/TrEMBL

A0A140T8S2

Related

ENSMUSP00000122466.3, ENSMUST00000131724.9

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142746.1 → NP_001136218.1 protocadherin-15 isoform CD3-1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (K) has a distinct 3' splice pattern, compared to variant A. The resulting isoform (CD3-1), also known as protocadherin-15-CD3 isoform 1, has a distinct and longer C-terminus, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, CO433511, DQ354413

Consensus CDS

CCDS56713.1

UniProtKB/TrEMBL

A0A140T8S2

Related

ENSMUSP00000135501.2, ENSMUST00000177107.8

Conserved Domains (1) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142747.1 → NP_001136219.1 protocadherin-15 isoform SI-1 precursor

See identical proteins and their annotated locations for NP_001136219.1

Status: VALIDATED

Description

Transcript Variant: This variant (M) has a distinct 3' splice pattern, compared to variant A. The resulting isoform (SI-1), also known as protocadherin-15-secreted isoform 1, has a substantially shorter and distinct C-terminus, compared to isoform CD1-1.

Source sequence(s)

AK139154, CJ166718

Consensus CDS

CCDS56712.1

UniProtKB/Swiss-Prot

Q99PJ1

Related

ENSMUSP00000135849.2, ENSMUST00000177420.7

Conserved Domains (1) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142748.1 → NP_001136220.1 protocadherin-15 isoform SI-2 precursor

See identical proteins and their annotated locations for NP_001136220.1

Status: VALIDATED

Description

Transcript Variant: This variant (N) lacks an alternate in-frame exon in the 5' coding region and has a distinct 3' splice pattern, compared to variant A. The resulting isoform (SI-2), also known as protocadherin-15-secreted isoform 2, lacks a 5-aa segment near the N-terminus and has a substantially shorter and distinct C-terminus, compared to isoform CD1-1.

Source sequence(s)

CJ166718, DQ354417

Consensus CDS

CCDS56714.1

UniProtKB/Swiss-Prot

Q99PJ1

Related

ENSMUSP00000120056.3, ENSMUST00000125006.9

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_001142760.1 → NP_001136232.1 protocadherin-15 isoform CD3-2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (L) lacks an alternate in-frame exon in the 5' coding region and has a distinct 3' splice pattern, compared to variant A. The resulting isoform (CD3-2), also known as protocadherin-15-CD3 isoform 2, lacks a 5-aa segment near the N-terminus and has a distinct and longer C-terminus, compared to isoform CD1-1.

Source sequence(s)

AC153858, AK139154, CJ166718, CO433511, DQ354414

Consensus CDS

CCDS56717.1

UniProtKB/TrEMBL

A0A140T8S2

Related

ENSMUSP00000141973.2, ENSMUST00000191854.6

Conserved Domains (1) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain
NM_023115.3 → NP_075604.2 protocadherin-15 isoform CD1-1 precursor

See identical proteins and their annotated locations for NP_075604.2

Status: VALIDATED

Description

Transcript Variant: This variant (A) encodes isoform CD1-1, also known as protocadherin-15-CD1 isoform 1.

Source sequence(s)

AC121142, AC153858, AF281899, CJ166718

Consensus CDS

CCDS35934.1

UniProtKB/Swiss-Prot

D6RCH0, E9Q7D7, E9Q7R1, E9Q7R2, F6KJX4, F6KKG6, F6R5Z7, F6RBV2, F6U3Q6, F6UPC9, F6VPR3, F6WUN7, F6X715, F6XPA1, F6Y0A5, F6YP25, F6YZQ9, F7ASH0, F7CIN1, F7D5J8, F7DFU0, F8VQ61, H3BKS0, Q0ZM15, Q0ZM16, Q0ZM18, Q0ZM19, Q0ZM20, Q0ZM21, Q0ZM22, Q0ZM23, Q0ZM24, Q0ZM25, Q0ZM26, Q0ZM27, Q0ZM28, Q0ZM29, Q0ZM30, Q0ZM31, Q0ZM32, Q0ZM33, Q0ZM34, Q0ZM35, Q0ZM37, Q2VQG7, Q3URZ1, Q3UTS7, Q99PJ1

UniProtKB/TrEMBL

E9Q159

Related

ENSMUSP00000141792.2, ENSMUST00000193361.6

Conserved Domains (1) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

72932003..74485663

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017313785.3 → XP_017169274.1 protocadherin-15 isoform X7

UniProtKB/TrEMBL

A0A0A6YY17

Conserved Domains (2) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

pfam18432
Location:36 → 145

ECD; Extracellular Cadherin domain
XM_017313784.3 → XP_017169273.1 protocadherin-15 isoform X1

UniProtKB/TrEMBL

A0A0A6YXB5

Related

ENSMUSP00000141920.2, ENSMUST00000195531.6

Conserved Domains (2) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

pfam18432
Location:36 → 145

ECD; Extracellular Cadherin domain
XM_006513155.5 → XP_006513218.1 protocadherin-15 isoform X2

UniProtKB/TrEMBL

A0A140T8S2

Conserved Domains (2) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

pfam18432
Location:36 → 145

ECD; Extracellular Cadherin domain
XM_006513156.5 → XP_006513219.1 protocadherin-15 isoform X3

UniProtKB/TrEMBL

A0A140T8S2

Related

ENSMUSP00000142173.2, ENSMUST00000193739.6

Conserved Domains (2) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

pfam18432
Location:36 → 145

ECD; Extracellular Cadherin domain
XM_036155565.1 → XP_036011458.1 protocadherin-15 isoform X5

UniProtKB/TrEMBL

A0A0A6YXB5

Conserved Domains (3) summary

cd11304
Location:727 → 820

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:310 → 398

CA; Cadherin repeats

pfam18432
Location:36 → 145

ECD; Extracellular Cadherin domain
XM_036155566.1 → XP_036011459.1 protocadherin-15 isoform X6

UniProtKB/TrEMBL

A0A140T8S2

Conserved Domains (3) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:305 → 393

CA; Cadherin repeats

pfam18432
Location:31 → 140

ECD; Extracellular Cadherin domain
XM_036155564.1 → XP_036011457.1 protocadherin-15 isoform X4

UniProtKB/TrEMBL

A0A140T8S2

Conserved Domains (3) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:305 → 393

CA; Cadherin repeats

pfam18432
Location:31 → 140

ECD; Extracellular Cadherin domain
XM_036155563.1 → XP_036011456.1 protocadherin-15 isoform X4

UniProtKB/TrEMBL

A0A140T8S2

Conserved Domains (3) summary

cd11304
Location:722 → 815

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:305 → 393

CA; Cadherin repeats

pfam18432
Location:31 → 140

ECD; Extracellular Cadherin domain