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Hnrnpd heterogeneous nuclear ribonucleoprotein D [ Mus musculus (house mouse) ]

Gene ID: 11991, updated on 11-Apr-2024

Summary

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Official Symbol
Hnrnpdprovided by MGI
Official Full Name
heterogeneous nuclear ribonucleoprotein Dprovided by MGI
Primary source
MGI:MGI:101947
See related
Ensembl:ENSMUSG00000000568 AllianceGenome:MGI:101947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Auf1; Hnrpd
Summary
Predicted to enable chromatin binding activity; histone deacetylase binding activity; and nucleic acid binding activity. Involved in mRNA transcription by RNA polymerase II and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within regulation of mRNA stability. Located in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 36.7), CNS E14 (RPKM 24.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E4; 5 48.46 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (100103794..100126926, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (99955935..99979130, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13715 Neighboring gene predicted gene, 42126 Neighboring gene STARR-positive B cell enhancer mm9_chr5:100335210-100335511 Neighboring gene vesicle-associated membrane protein 9 Neighboring gene RIKEN cDNA 4930524J08 gene Neighboring gene STARR-seq mESC enhancer starr_13719 Neighboring gene predicted gene, 42127 Neighboring gene STARR-positive B cell enhancer ABC_E2161 Neighboring gene STARR-seq mESC enhancer starr_13720 Neighboring gene heterogeneous nuclear ribonucleoprotein D-like Neighboring gene enolase-phosphatase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8822 Neighboring gene transmembrane protein 150C, opposite strand Neighboring gene transmembrane protein 150C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs. Abbadi D, et al. Proc Natl Acad Sci U S A, 2019 Jun 4. PMID 31113881, Free PMC Article
  2. Deregulated AUF1 Assists BMP-EZH2-Mediated Delayed Wound Healing during Candida albicans Infection. Mahadik K, et al. J Immunol, 2018 Dec 15. PMID 30429285
  3. Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity. Chenette DM, et al. Cell Rep, 2016 Aug 2. PMID 27452471, Free PMC Article
  4. Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression. Fellows A, et al. Int Immunopharmacol, 2013 Sep. PMID 23747316, Free PMC Article
  5. AUF1 is involved in splenic follicular B cell maintenance. Sadri N, et al. BMC Immunol, 2010 Jan 11. PMID 20064252, Free PMC Article

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
    Title: RNA binding protein AUF1/HNRNPD regulates nuclear export, stability and translation of SNCA transcripts.
  2. AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1-Dicer-1-mir-122 hierarchy.
    Title: AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1-Dicer-1-mir-122 hierarchy.
  3. AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.
    Title: AUF1 protects against ferroptosis to alleviate sepsis-induced acute lung injury by regulating NRF2 and ATF3.
  4. AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression.
    Title: AUF1, an mRNA decay factor, has a discordant role in Cpeb1 expression.
  5. AUF1 therefore orchestrates muscle stem cell proliferation, self-renewal, myoblast differentiation, and ultimately formation of muscle fibers through targeted, staged mRNA decay.
    Title: Muscle development and regeneration controlled by AUF1-mediated stage-specific degradation of fate-determining checkpoint mRNAs.
  6. In this study, AUF1, was posttranslationally destabilized to bring about activation of BMP signaling and wound healing during Candida albicans infection
    Title: Deregulated AUF1 Assists BMP-EZH2-Mediated Delayed Wound Healing during Candida albicans Infection.
  7. Study identified RANKL and BCL6 mRNA as targets of AUF1 p42. Detailed analysis of 3'UTRs revealed for both that full instability required two elements, which are conserved in evolution. In RANKL mRNA both elements are AU-rich and separated by 30 bases, while in BCL6 mRNA one is AU-rich and 60 bases from a non-AU-rich element that potentially forms a stem-loop structure.
    Title: Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each.
  8. Control of ARE-mRNA decay by AUF1 represents a mechanism for adult stem cell regulation.
    Title: Targeted mRNA Decay by RNA Binding Protein AUF1 Regulates Adult Muscle Stem Cell Fate, Promoting Skeletal Muscle Integrity.
  9. These results suggest that the post-transcriptional regulation of ATX expression by HuR and AUF1 modulates cancer cell migration.
    Title: Autotaxin Expression Is Regulated at the Post-transcriptional Level by the RNA-binding Proteins HuR and AUF1.
  10. MEF2C is a key effector of the myogenesis program promoted by AUF1.
    Title: RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • C230004L04

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR AU-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables minor groove of adenine-thymine-rich DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nitric oxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to putrescine ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomerase RNA reverse transcriptase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
involved_in response to rapamycin ISO
Inferred from Sequence Orthology
more info
  
involved_in response to sodium phosphate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein D0
Names
AU-rich element RNA-binding protein 1
hnRNP D0

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077265.2 → NP_001070733.1  heterogeneous nuclear ribonucleoprotein D0 isoform a

    See identical proteins and their annotated locations for NP_001070733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC022062, BC049098, CX567003
    Consensus CDS
    CCDS39182.1
    UniProtKB/Swiss-Prot
    Q60667, Q60668, Q80ZJ0, Q91X94
    Related
    ENSMUSP00000132735.2, ENSMUST00000172361.8
    Conserved Domains (3) summary
    cd12575
    Location:99 → 172
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain

  2. NM_001077266.2 → NP_001070734.1  heterogeneous nuclear ribonucleoprotein D0 isoform b

    See identical proteins and their annotated locations for NP_001070734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which lacks an internal segment and is shorter, compared to isoform a.
    Source sequence(s)
    AC022062, AK077409, BC049098, CA451481, CK618758
    Consensus CDS
    CCDS39180.1
    UniProtKB/TrEMBL
    G3X9W0
    Related
    ENSMUSP00000108561.4, ENSMUST00000112939.10
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  3. NM_001077267.2 → NP_001070735.1  heterogeneous nuclear ribonucleoprotein D0 isoform d

    See identical proteins and their annotated locations for NP_001070735.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons, one each in the 5' and the 3' coding regions, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AC022062, BC049098, CF751545, CK618758
    Consensus CDS
    CCDS51571.1
    UniProtKB/TrEMBL
    G5E8G0
    Related
    ENSMUSP00000072533.7, ENSMUST00000072750.13
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  4. NM_007516.3 → NP_031542.2  heterogeneous nuclear ribonucleoprotein D0 isoform c

    See identical proteins and their annotated locations for NP_031542.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform c, which lacks an internal segment and is shorter, compared to isoform a.
    Source sequence(s)
    AC022062, BC049098
    Consensus CDS
    CCDS39181.1
    UniProtKB/Swiss-Prot
    Q60668
    Related
    ENSMUSP00000019128.9, ENSMUST00000019128.15
    Conserved Domains (3) summary
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:99 → 172
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    100103794..100126926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164755.1 → XP_036020648.1  heterogeneous nuclear ribonucleoprotein D0 isoform X4

    UniProtKB/TrEMBL
    G5E8G0
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  2. XM_036164753.1 → XP_036020646.1  heterogeneous nuclear ribonucleoprotein D0 isoform X2

    UniProtKB/TrEMBL
    G3X9W0
    Conserved Domains (3) summary
    cd12583
    Location:164 → 238
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:80 → 153
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  3. XM_036164754.1 → XP_036020647.1  heterogeneous nuclear ribonucleoprotein D0 isoform X3

    Conserved Domains (3) summary
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain
    cd12756
    Location:99 → 172
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

  4. XM_006534735.5 → XP_006534798.1  heterogeneous nuclear ribonucleoprotein D0 isoform X1

    See identical proteins and their annotated locations for XP_006534798.1

    UniProtKB/Swiss-Prot
    Q60667, Q60668, Q80ZJ0, Q91X94
    Conserved Domains (3) summary
    cd12575
    Location:99 → 172
    RRM1_hnRNPD_like; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP D0, hnRNP A/B, hnRNP DL and similar proteins
    cd12583
    Location:183 → 257
    RRM2_hnRNPD; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    pfam08143
    Location:60 → 78
    CBFNT; CBFNT (NUC161) domain

  5. XM_036164756.1 → XP_036020649.1  heterogeneous nuclear ribonucleoprotein D0 isoform X5

    UniProtKB/TrEMBL
    F6ZV59
    Conserved Domains (2) summary
    cd12583
    Location:85 → 159
    RRM2_hnRNPD; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins
    cd12756
    Location:1 → 74
    RRM1_hnRNPD; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) and similar proteins

RNA

  1. XR_004942430.1 RNA Sequence

  2. XR_389258.5 RNA Sequence

  3. XR_389257.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60668.2 GenPept UniProtKB/Swiss-Prot:Q60668

Gene LinkOut

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