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Slc7a3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 [ Mus musculus (house mouse) ]

Gene ID: 11989, updated on 11-Apr-2024

Summary

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Official Symbol
Slc7a3provided by MGI
Official Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 3provided by MGI
Primary source
MGI:MGI:1100521
See related
Ensembl:ENSMUSG00000031297 AllianceGenome:MGI:1100521
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAT3; Atrc3; CAT-3; SLC7A1; SLC7A2
Summary
The protein encoded by this gene is a member of the system y+ cationic amino acid transporter family. Proteins of this family allow uptake of arginine from extracellular media. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Broad expression in CNS E18 (RPKM 4.8), limb E14.5 (RPKM 1.7) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3- D; X 43.72 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100122752..100134058, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101079146..101090452, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene high mobility group protein B1-like Neighboring gene predicted gene 3820 Neighboring gene STARR-seq mESC enhancer starr_47640 Neighboring gene sorting nexin 12 Neighboring gene predicted gene, 24061 Neighboring gene predicted gene, 22472

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake. Lowman XH, et al. Cell Rep, 2019 Mar 12. PMID 30865893, Free PMC Article
  2. Increased Cat3-mediated cationic amino acid transport functionally compensates in Cat1 knockout cell lines. Nicholson B, et al. J Biol Chem, 1998 Jun 12. PMID 9614060
  3. Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis. Yan Y, et al. Sci Rep, 2022 Dec 17. PMID 36528691, Free PMC Article
  4. A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. Ito K, et al. J Biol Chem, 1997 Oct 17. PMID 9334265
  5. Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase. Bae SY, et al. Biochim Biophys Acta, 2005 Aug 15. PMID 16085056

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
    Title: Extracellular arginine is required but the arginine transporter CAT3 (Slc7a3) is dispensable for mouse normal and malignant hematopoiesis.
  2. Slc7a3 expression is significantly induced by p53 upon glutamine deprivation.
    Title: p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake.
  3. knockdown impaired AMPK-PPAR-alpha signaling and resulted in lipid accumulation under fasting
    Title: Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting.
  4. In a neuronal cell model, y+,L and y+ transport systems are the predominant form of arginine uptake mechanisms and the transport of arginine is altered by membrane potential and redox factors.
    Title: Y+ and y+ L arginine transporters in neuronal cells expressing tyrosine hydroxylase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-arginine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-lysine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-lysine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-ornithine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-ornithine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables basic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables basic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-arginine import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-arginine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within L-arginine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-ornithine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in L-ornithine transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within basic amino acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in ornithine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
cationic amino acid transporter 3
Names
amino acid transporter, cationic 3
cationic amino acid transporter y+
solute carrier family 7 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301840.1 → NP_001288769.1  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_001288769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK077593, AK141558
    Consensus CDS
    CCDS30309.1
    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Related
    ENSMUSP00000073582.5, ENSMUST00000073927.5
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

  2. NM_007515.3 → NP_031541.1  cationic amino acid transporter 3

    See identical proteins and their annotated locations for NP_031541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK077593, AK141558, CD540305
    Consensus CDS
    CCDS30309.1
    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Related
    ENSMUSP00000098914.2, ENSMUST00000101362.8
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100122752..100134058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247513.2 → XP_011245815.1  cationic amino acid transporter 3 isoform X1

    See identical proteins and their annotated locations for XP_011245815.1

    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

  2. XM_006527753.3 → XP_006527816.1  cationic amino acid transporter 3 isoform X1

    See identical proteins and their annotated locations for XP_006527816.1

    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Related
    ENSMUSP00000109339.2, ENSMUST00000113710.8
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

  3. XM_036161792.1 → XP_036017685.1  cationic amino acid transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

  4. XM_036161793.1 → XP_036017686.1  cationic amino acid transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease

  5. XM_036161791.1 → XP_036017684.1  cationic amino acid transporter 3 isoform X1

    UniProtKB/Swiss-Prot
    B1AVE2, P70423
    UniProtKB/TrEMBL
    Q3TMH5
    Conserved Domains (1) summary
    TIGR00906
    Location:4 → 588
    2A0303; cationic amino acid transport permease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70423.1 GenPept UniProtKB/Swiss-Prot:P70423

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