Atp5if1 ATP synthase inhibitory factor subunit 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5if1provided by MGI
Official Full Name: ATP synthase inhibitory factor subunit 1provided by MGI
Primary source: MGI:MGI:1196457
See related: Ensembl:ENSMUSG00000054428 AllianceGenome:MGI:1196457
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: If1; Atpi; IF(1); Atpif1
Summary: This gene encodes a member of the ATPase inhibitor family of proteins. This protein has been shown to negatively regulate the ATP hydrolysis activity of the F1Fo-ATPase. Knockdown of this gene is associated with reduced heme synthesis in differentiating erythroid cells. Misregulation of this gene has been found to lead to increased aerobic glycolysis in mouse cancer cells, while high expression levels of this gene have been correlated with gastric and liver cancer severity in human patients. A pseudogene of this gene has been identified. [provided by RefSeq, Apr 2015]
Expression: Broad expression in liver E14 (RPKM 154.1), CNS E11.5 (RPKM 126.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.3; 4 65.51 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (132257870..132262746, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (132530555..132535450, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid.
Title: Enhanced glycolysis by ATPIF1 gene inactivation increased the anti-bacterial activities of neutrophils through induction of ROS and lactic acid.
IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.
Title: IF1 ablation prevents ATP synthase oligomerization, enhances mitochondrial ATP turnover and promotes an adenosine-mediated pro-inflammatory phenotype.
Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts.
Title: Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts.
ATP synthase inhibitory factor subunit 1 regulates islet beta-cell function via repression of mitochondrial homeostasis.
Title: ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis.
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIdelta.
Title: ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ.
This study unveils a functional relay between IF1 and optic atrophy 1 in central nervous system.
Title: Reduction of the ATPase inhibitory factor 1 (IF(1)) leads to visual impairment in vertebrates.
Data indicate that oxidative phosphorylation (OXPHOS) is inhibited in the liver of mice expressing human ATPase inhibitory factor 1 (hIF1).
Title: Down-regulation of oxidative phosphorylation in the liver by expression of the ATPase inhibitory factor 1 induces a tumor-promoter metabolic state.
PKA phosphorylates the ATPase inhibitory factor 1 and inactivates its capacity to bind and inhibit the mitochondrial H(+)-ATP synthase.
Title: PKA Phosphorylates the ATPase Inhibitory Factor 1 and Inactivates Its Capacity to Bind and Inhibit the Mitochondrial H(+)-ATP Synthase.
induces VEGF expression and promotes xenograft tumor-induced angiogenesis
Title: Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis.
IF1 is not an essential protein for mice despite its ubiquitous presence in eukaryotes.
Title: IF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AF002718 (e-PCR)
- UniSTS:159300

Atpif1 (e-PCR), detects polymorphism
- UniSTS:498299

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables ATPase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables angiostatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables mitochondrial proton-transporting ATP synthase complex binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in heme biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heme biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heme biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP-dependent activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrolase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATPase inhibitor, mitochondrial

Names: ATP synthase F1 subunit epsilon; ATPase inhibitory factor 1; inhibitor of F(1)F(o)-ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420763.1 → NP_001407692.1 ATPase inhibitor, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AL805897

UniProtKB/Swiss-Prot

O35143, Q9D879
NM_001420764.1 → NP_001407693.1 ATPase inhibitor, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AL805897

UniProtKB/Swiss-Prot

O35143, Q9D879
NM_001420765.1 → NP_001407694.1 ATPase inhibitor, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AL805897

UniProtKB/Swiss-Prot

O35143, Q9D879
NM_007512.5 → NP_031538.2 ATPase inhibitor, mitochondrial precursor

See identical proteins and their annotated locations for NP_031538.2

Status: VALIDATED

Source sequence(s)

AL805897

Consensus CDS

CCDS18727.1

UniProtKB/Swiss-Prot

O35143, Q9D879

Conserved Domains (1) summary

pfam04568
Location:36 → 87

IATP; Mitochondrial ATPase inhibitor, IATP