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Atp5pf ATP synthase peripheral stalk subunit F6 [ Mus musculus (house mouse) ]

Gene ID: 11957, updated on 5-Apr-2024

Summary

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Official Symbol
Atp5pfprovided by MGI
Official Full Name
ATP synthase peripheral stalk subunit F6provided by MGI
Primary source
MGI:MGI:107777
See related
Ensembl:ENSMUSG00000022890 AllianceGenome:MGI:107777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CF6; Atp5j
Summary
The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in heart adult (RPKM 199.5), kidney adult (RPKM 107.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 C3.3; 16 46.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84624754..84632495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84827871..84835857, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41365 Neighboring gene predicted gene, 32202 Neighboring gene STARR-seq mESC enhancer starr_41367 Neighboring gene junction adhesion molecule 2 Neighboring gene STARR-positive B cell enhancer ABC_E5555 Neighboring gene predicted gene, 46557 Neighboring gene GA repeat binding protein, alpha Neighboring gene STARR-seq mESC enhancer starr_41374 Neighboring gene STARR-seq mESC enhancer starr_41375 Neighboring gene predicted gene 10791 Neighboring gene amyloid beta precursor protein Neighboring gene predicted gene, 49227

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice. Izumiyama K, et al. Hypertens Res, 2012 May. PMID 22258022
  2. Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice. Sagara S, et al. J Hypertens, 2012 Apr. PMID 22306848
  3. Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice. Osanai T, et al. Diabetologia, 2012 Feb. PMID 22038518
  4. Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice. Ashitate T, et al. J Hypertens, 2010 Nov. PMID 20811295
  5. Identification of functional elements in the murine Gabp alpha/ATP synthase coupling factor 6 bi-directional promoter. Patton J, et al. Gene, 2006 Mar 15. PMID 16309857

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coupling factor 6 overexpression induced salt-sensitive hypertension, complicated by systolic cardiac dysfunction, but its onset was delayed in females. Estrogen has an important role in the regulation of coupling factor 6-mediated pathophysiology.
    Title: Estrogen attenuates coupling factor 6-induced salt-sensitive hypertension and cardiac systolic dysfunction in mice.
  2. Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by downregulating Akt signaling, thereby cancelling its benefit for cardiac function in mice.
    Title: Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.
  3. CF6 plays a crucial role in the development of insulin resistance and hypertension
    Title: Coupling factor 6-induced activation of ecto-F1F(o) complex induces insulin resistance, mild glucose intolerance and elevated blood pressure in mice.
  4. coupling factor 6 induces the development of systolic dysfunction and upregulation of nicotinamide adenine dinucleotide phosphate oxidase in the heart under the high-salt diet
    Title: Overexpression of coupling factor 6 causes cardiac dysfunction under high-salt diet in mice.
  5. identification of functional elements in bi-directional promoter
    Title: Identification of functional elements in the murine Gabp alpha/ATP synthase coupling factor 6 bi-directional promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP synthase-coupling factor 6, mitochondrial
Names
ATP synthase coupling factor VI
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
ATPase subunit F6
NP_001289142.1
NP_001289143.1
NP_001289144.1
NP_001289145.1
NP_001345428.1
NP_001345429.1
NP_001403518.1
NP_001403520.1
NP_001403521.1
NP_001403522.1
NP_001403523.1
NP_001403524.1
NP_001403526.1
NP_001403527.1
NP_001403529.1
NP_001403530.1
NP_058035.1
XP_030104798.1
XP_036015646.1
XP_036015647.1
XP_036015648.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302213.2 → NP_001289142.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289142.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Related
    ENSMUSP00000109829.2, ENSMUST00000114191.8
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  2. NM_001302214.2 → NP_001289143.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  3. NM_001302215.2 → NP_001289144.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289144.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  4. NM_001302216.2 → NP_001289145.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  5. NM_001358499.2 → NP_001345428.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  6. NM_001358500.2 → NP_001345429.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  7. NM_001416589.1 → NP_001403518.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  8. NM_001416591.1 → NP_001403520.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  9. NM_001416592.1 → NP_001403521.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  10. NM_001416593.1 → NP_001403522.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  11. NM_001416594.1 → NP_001403523.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  12. NM_001416595.1 → NP_001403524.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  13. NM_001416597.1 → NP_001403526.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  14. NM_001416598.2 → NP_001403527.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  15. NM_001416600.1 → NP_001403529.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  16. NM_001416601.1 → NP_001403530.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: VALIDATED

    Source sequence(s)
    AC164162
    UniProtKB/Swiss-Prot
    P97450

  17. NM_016755.4 → NP_058035.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Related
    ENSMUSP00000023608.8, ENSMUST00000023608.14
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

RNA

  1. NR_184383.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164162

  2. NR_184384.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164162

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    84624754..84632495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159754.1 → XP_036015647.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  2. XM_030248938.2 → XP_030104798.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  3. XM_036159755.1 → XP_036015648.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

  4. XM_036159753.1 → XP_036015646.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    P97450
    UniProtKB/TrEMBL
    E9QAD6
    Related
    ENSMUSP00000109831.2, ENSMUST00000114193.8
    Conserved Domains (1) summary
    pfam05511
    Location:1 → 95
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97450.1 GenPept UniProtKB/Swiss-Prot:P97450

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