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Atp5f1c ATP synthase F1 subunit gamma [ Mus musculus (house mouse) ]

Gene ID: 11949, updated on 11-Apr-2024

Summary

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Official Symbol
Atp5f1cprovided by MGI
Official Full Name
ATP synthase F1 subunit gammaprovided by MGI
Primary source
MGI:MGI:1261437
See related
Ensembl:ENSMUSG00000025781 AllianceGenome:MGI:1261437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5c1; 1700094F02Rik
Summary
Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrial inner membrane and myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ATP5F1C (ATP synthase F1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 316.7), kidney adult (RPKM 177.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 6.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10060841..10085321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10056030..10080510, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 31290 Neighboring gene TATA-box binding protein associated factor 3 Neighboring gene predicted gene, 54137 Neighboring gene STARR-positive B cell enhancer ABC_E11119 Neighboring gene predicted gene, 23608 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MyoD is indispensable for muscle-specific alternative splicing in mouse mitochondrial ATP synthase gamma-subunit pre-mRNA. Ichida M, et al. J Biol Chem, 1998 Apr 3. PMID 9525963
  2. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Li Y, et al. Nat Commun, 2020 Sep 24. PMID 32973183, Free PMC Article
  3. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
  4. Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy. Brody MJ, et al. PLoS One, 2012. PMID 23236519, Free PMC Article
  5. Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1. Sano M, et al. Cell Metab, 2007 Feb. PMID 17276355

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in myelin sheath HDA PubMed 
part_of proton-transporting ATP synthase complex, catalytic core F(1) ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP synthase subunit gamma, mitochondrial
Names
ATP synthase gamma-subunit gene encoding a mitochondrial protein
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
F-ATPase gamma subunit
F1 gamma
NP_001106209.1
NP_001361570.1
NP_065640.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112738.1 → NP_001106209.1  ATP synthase subunit gamma, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_001106209.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK158675, BC055785
    Consensus CDS
    CCDS50497.1
    UniProtKB/TrEMBL
    Q8C2Q8, Q9D9D7, Q9ERA8
    Related
    ENSMUSP00000110546.2, ENSMUST00000114896.8
    Conserved Domains (1) summary
    TIGR01146
    Location:2 → 273
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  2. NM_001374641.1 → NP_001361570.1  ATP synthase subunit gamma, mitochondrial isoform c

    Status: VALIDATED

    Source sequence(s)
    AL772367
    Consensus CDS
    CCDS89426.1
    UniProtKB/TrEMBL
    A2AKU9, Q9D9D7, Q9ERA8
    Related
    ENSMUSP00000026887.8, ENSMUST00000026887.14
    Conserved Domains (1) summary
    TIGR01146
    Location:26 → 297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

  3. NM_020615.4 → NP_065640.2  ATP synthase subunit gamma, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_065640.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform a).
    Source sequence(s)
    AK158675, BC055785
    Consensus CDS
    CCDS38045.1
    UniProtKB/Swiss-Prot
    Q91VR2
    UniProtKB/TrEMBL
    Q3UD06, Q9D9D7, Q9ERA8
    Related
    ENSMUSP00000110547.3, ENSMUST00000114897.9
    Conserved Domains (1) summary
    TIGR01146
    Location:26 → 297
    ATPsyn_F1gamma; ATP synthase, F1 gamma subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    10060841..10085321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VR2.1 GenPept UniProtKB/Swiss-Prot:Q91VR2

Gene LinkOut

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