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Neurog2 neurogenin 2 [ Mus musculus (house mouse) ]

Gene ID: 11924, updated on 26-Mar-2024

Summary

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Official Symbol
Neurog2provided by MGI
Official Full Name
neurogenin 2provided by MGI
Primary source
MGI:MGI:109619
See related
Ensembl:ENSMUSG00000027967 AllianceGenome:MGI:109619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ngn2; Atoh4; ngn-2; Math4A; bHLHa8
Summary
Enables E-box binding activity. Involved in positive regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and integumental system. Orthologous to human NEUROG2 (neurogenin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 28.5), whole brain E14.5 (RPKM 22.8) and 2 other tissues See more
Orthologs
human all
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Genomic context

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See Neurog2 in Genome Data Viewer
Location:
3 G2; 3 56.54 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127426382..127429285)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127632733..127635636)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene predicted gene, 40147 Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons. Thoma EC, et al. PLoS One, 2012. PMID 22719915, Free PMC Article
  2. Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors. Lunn JS, et al. Neurobiol Dis, 2012 Apr. PMID 22245661, Free PMC Article
  3. Proliferating neuronal progenitors in the postnatal hippocampus transiently express the proneural gene Ngn2. Ozen I, et al. Eur J Neurosci, 2007 May. PMID 17466019
  4. BMP and FGF-2 regulate neurogenin-2 expression and the differentiation of sensory neurons and glia. Ota M, et al. Dev Dyn, 2006 Mar. PMID 16425218
  5. CA1 pyramidal cell diversity is rooted in the time of neurogenesis. Cavalieri D, et al. Elife, 2021 Nov 1. PMID 34723790, Free PMC Article

See all (528) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
    Title: Ascl1 and Ngn2 convert mouse embryonic stem cells to neurons via functionally distinct paths.
  2. Neurog2 regulates Isl1 to modulate horizontal cell number.
    Title: Neurog2 regulates Isl1 to modulate horizontal cell number.
  3. Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1.
    Title: Reprogramming astrocytes to motor neurons by activation of endogenous Ngn2 and Isl1.
  4. Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
    Title: Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2.
  5. A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
    Title: A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord.
  6. Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.
    Title: Neurog2 directly converts astrocytes into functional neurons in midbrain and spinal cord.
  7. Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
    Title: Initiation of Otx2 expression in the developing mouse retina requires a unique enhancer and either Ascl1 or Neurog2 activity.
  8. WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
    Title: WNT signaling suppresses oligodendrogenesis via Ngn2-dependent direct inhibition of Olig2 expression.
  9. Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis.
    Title: Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and Is Required for the Early Phase of Neurogenesis.
  10. Overexpression of Fbxo9 in neural crest progenitors down-regulated Neurog2 protein expression through ubiquitination and promoted the glial lineage at the expense of neuronal differentiation.
    Title: Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization.
Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables E-box binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of Cajal-Retzius cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell fate commitment IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within central nervous system neuron development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within central nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in forebrain development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neurogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
neurogenin-2
Names
atonal homolog 4
helix-loop-helix protein mATH-4A
protein atonal homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009718.4 → NP_033848.1  neurogenin-2

    See identical proteins and their annotated locations for NP_033848.1

    Status: VALIDATED

    Source sequence(s)
    AC158308
    Consensus CDS
    CCDS17825.1
    UniProtKB/Swiss-Prot
    P70237, P70447
    UniProtKB/TrEMBL
    I3PQW5, Q6GTH9
    Related
    ENSMUSP00000029587.8, ENSMUST00000029587.9
    Conserved Domains (1) summary
    cd19717
    Location:104 → 172
    bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    127426382..127429285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252394.1 → XP_030108254.1  neurogenin-2 isoform X1

    UniProtKB/Swiss-Prot
    P70237, P70447
    UniProtKB/TrEMBL
    I3PQW5, Q6GTH9
    Conserved Domains (1) summary
    cd19717
    Location:104 → 172
    bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70447.1 GenPept UniProtKB/Swiss-Prot:P70447

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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