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Ate1 arginyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 11907, updated on 21-Apr-2024

Summary

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Official Symbol
Ate1provided by MGI
Official Full Name
arginyltransferase 1provided by MGI
Primary source
MGI:MGI:1333870
See related
Ensembl:ENSMUSG00000030850 AllianceGenome:MGI:1333870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables arginyltransferase activity. Acts upstream of or within protein arginylation. Located in cytoplasm and nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and notochord. Orthologous to human ATE1 (arginyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 5.0), CNS E18 (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 73.19 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (129993219..130122349, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (130391493..130520619, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33661 Neighboring gene predicted gene, 39097 Neighboring gene ring finger and WD repeat domain 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_20244 Neighboring gene VISTA enhancer mm938 Neighboring gene STARR-seq mESC enhancer starr_20245 Neighboring gene STARR-seq mESC enhancer starr_20247 Neighboring gene predicted gene 4275 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene transforming, acidic coiled-coil containing protein 2 Neighboring gene STARR-seq mESC enhancer starr_20252 Neighboring gene predicted gene, 34365

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Arginyltransferase (Ate1) regulates the RGS7 protein level and the sensitivity of light-evoked ON-bipolar responses. Fina ME, et al. Sci Rep, 2021 Apr 30. PMID 33931669, Free PMC Article
  2. ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis. Van V, et al. ACS Chem Biol, 2020 Dec 18. PMID 33228359, Free PMC Article
  3. Target site specificity and in vivo complexity of the mammalian arginylome. Wang J, et al. Sci Rep, 2018 Nov 1. PMID 30385798, Free PMC Article
  4. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Wang J, et al. Sci Rep, 2017 Sep 12. PMID 28900170, Free PMC Article
  5. Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development. Wang J, et al. Dev Biol, 2017 Oct 1. PMID 28844905, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
    Title: The Final Maturation State of β-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1.
  2. ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis.
    Title: ATE1-Mediated Post-Translational Arginylation Is an Essential Regulator of Eukaryotic Cellular Homeostasis.
  3. Results strongly suggest that, the inhibition of ATE1 enzyme or knockout of Ate1 gene in pre-adipocytes can suppress adipogenesis via regulation of PPARgamma expression at transcript as well as protein level.
    Title: Arginylation regulates adipogenesis by regulating expression of PPARγ at transcript and protein level.
  4. Our analysis reveals multiple proteins with potential ATE1 target sites and expand our understanding of the biological complexity of the intracellular arginylome.
    Title: Target site specificity and in vivo complexity of the mammalian arginylome.
  5. study revealed a novel role of Ate1 in suppressing prostate cancer metastasis, which has a profound significance for establishing metastatic indicators for prostate cancer, and for finding potential treatments to prevent its metastasis.
    Title: Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis.
  6. This study clarifies the role of Ate1/arginylation in stress response.
    Title: Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response.
  7. zipcode-mediated co-targeting of Ate1 and beta-actin mRNA leads to localized co-translational arginylation of beta-actin that drives the growth cone migration and neurite outgrowth.
    Title: Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development.
  8. Ate1 is downregulated in several types of human cancer samples at the protein level, and that its transcription level inversely correlates with metastatic progression and patient survival.
    Title: Arginyltransferase suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers.
  9. four major isoforms of mouse R-transferase have similar Nt-arginylation specificities in vitro, contrary to the claim about the specificity of some Ate1 isoforms for N-terminal Cys
    Title: Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.
  10. the crucial role of ATE1 in neural tube development is directly related to proper turn-over of the RGS4 protein, which participate in the oxygen-sensing mechanism in the cells.
    Title: Ablation of Arg-tRNA-protein transferases results in defective neural tube development.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginyl-tRNA--protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginyl-tRNA--protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein arginylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein arginylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arginyl-tRNA--protein transferase 1
Names
R-transferase 1
arginine-tRNA--protein transferase 1
NP_001025066.1
NP_001129526.1
NP_001258272.1
NP_001389570.1
NP_001389571.1
NP_001389572.1
NP_001389573.1
NP_001389574.1
NP_001389575.1
NP_001389576.1
NP_001389577.1
NP_038827.2
XP_011239961.1
XP_036008502.1
XP_036008503.1
XP_036008504.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029895.4 → NP_001025066.1  arginyl-tRNA--protein transferase 1 isoform 3

    See identical proteins and their annotated locations for NP_001025066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure, compared to variant 1. This difference causes translation initiation at an upstream AUG and results in an isoform (3) that has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS21901.1
    UniProtKB/TrEMBL
    Q4FCQ7, Q80YP1, Q8BP95
    Related
    ENSMUSP00000091556.4, ENSMUST00000094017.5
    Conserved Domains (2) summary
    pfam04376
    Location:16 → 85
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:281 → 422
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  2. NM_001136054.3 → NP_001129526.1  arginyl-tRNA--protein transferase 1 isoform 4

    See identical proteins and their annotated locations for NP_001129526.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 4.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS52414.1
    UniProtKB/TrEMBL
    Q80YP1
    Related
    ENSMUSP00000043365.8, ENSMUST00000035458.15
    Conserved Domains (2) summary
    pfam04376
    Location:20 → 92
    ATE_N; Arginine-tRNA-protein transferase, N terminus
    pfam04377
    Location:288 → 429
    ATE_C; Arginine-tRNA-protein transferase, C terminus

  3. NM_001271343.2 → NP_001258272.1  arginyl-tRNA--protein transferase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' structure and an alternate in-frame exon in the coding region, compared to variant 1. These differences cause translation initiation at an upstream AUG and result in an isoform (2) that has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS72051.1
    UniProtKB/TrEMBL
    J3QNU1
    Related
    ENSMUSP00000136956.2, ENSMUST00000178534.8
    Conserved Domains (2) summary
    pfam04376
    Location:16 → 85
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:282 → 420
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  4. NM_001402641.1 → NP_001389570.1  arginyl-tRNA--protein transferase 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606
    UniProtKB/TrEMBL
    A0A1L1SQ41
    Related
    ENSMUSP00000148888.2, ENSMUST00000216011.2

  5. NM_001402642.1 → NP_001389571.1  arginyl-tRNA--protein transferase 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

  6. NM_001402643.1 → NP_001389572.1  arginyl-tRNA--protein transferase 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

  7. NM_001402644.1 → NP_001389573.1  arginyl-tRNA--protein transferase 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

  8. NM_001402645.1 → NP_001389574.1  arginyl-tRNA--protein transferase 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

  9. NM_001402646.1 → NP_001389575.1  arginyl-tRNA--protein transferase 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC122258

  10. NM_001402647.1 → NP_001389576.1  arginyl-tRNA--protein transferase 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC122258

  11. NM_001402648.1 → NP_001389577.1  arginyl-tRNA--protein transferase 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC122258

  12. NM_013799.4 → NP_038827.2  arginyl-tRNA--protein transferase 1 isoform 1

    See identical proteins and their annotated locations for NP_038827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC122258, AC157606
    Consensus CDS
    CCDS21902.1
    UniProtKB/Swiss-Prot
    Q4FCQ6, Q4FCQ7, Q8CFP7, Q9Z2A4, Q9Z2A5
    Related
    ENSMUSP00000033139.8, ENSMUST00000033139.15
    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:288 → 427
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

RNA

  1. NR_175281.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122258, AC157606

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    129993219..130122349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152610.1 → XP_036008503.1  arginyl-tRNA--protein transferase 1 isoform X5

    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:288 → 418
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  2. XM_036152609.1 → XP_036008502.1  arginyl-tRNA--protein transferase 1 isoform X3

    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:331 → 461
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  3. XM_036152611.1 → XP_036008504.1  arginyl-tRNA--protein transferase 1 isoform X7

    Conserved Domains (1) summary
    pfam04377
    Location:34 → 173
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

  4. XM_011241659.1 → XP_011239961.1  arginyl-tRNA--protein transferase 1 isoform X4

    Conserved Domains (2) summary
    pfam04376
    Location:23 → 92
    ATE_N; Arginine-tRNA-protein transferase, N-terminus
    pfam04377
    Location:331 → 460
    ATE_C; Arginine-tRNA-protein transferase, C-terminus

RNA

  1. XR_004934000.1 RNA Sequence

  2. XR_004933999.1 RNA Sequence

  3. XR_004934001.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2A5.2 GenPept UniProtKB/Swiss-Prot:Q9Z2A5

Gene LinkOut

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