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MORN4 MORN repeat containing 4 [ Homo sapiens (human) ]

Gene ID: 118812, updated on 5-Mar-2024

Summary

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Official Symbol
MORN4provided by HGNC
Official Full Name
MORN repeat containing 4provided by HGNC
Primary source
HGNC:HGNC:24001
See related
Ensembl:ENSG00000171160 MIM:617736; AllianceGenome:HGNC:24001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UTA; rtp; C10orf83; bA548K23.4
Summary
Predicted to be involved in response to axon injury. Located in cytoplasm and filopodium tip. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in brain (RPKM 7.3), kidney (RPKM 3.8) and 23 other tissues See more
Orthologs
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Genomic context

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Location:
10q24.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97614555..97634156, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98494762..98514356, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99374312..99393913, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14301 Neighboring gene ankyrin repeat domain 2 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene chromosome 10 open reading frame 62 Neighboring gene Sharpr-MPRA regulatory region 10262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99366549-99367050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99367051-99367550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3854 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99399170-99399353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3856 Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99411103-99412302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99435535-99436034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Invertebrate and vertebrate class III myosins interact with MORN repeat-containing adaptor proteins. Mecklenburg KL, et al. PLoS One, 2015. PMID 25822849, Free PMC Article
  2. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. Bhattacharya MR, et al. J Neurosci, 2012 Apr 11. PMID 22496551, Free PMC Article
  3. Drosophila retinophilin contains MORN repeats and is conserved in humans. Mecklenburg KL. Mol Genet Genomics, 2007 May. PMID 17285308
  4. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article
  5. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25925

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in response to axon injury IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in filopodium tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in stereocilium tip ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MORN repeat-containing protein 4
Names
44050 protein
protein 44050
retinophilin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098831.2 → NP_001092301.1  MORN repeat-containing protein 4

    See identical proteins and their annotated locations for NP_001092301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ431726
    Consensus CDS
    CCDS7468.1
    UniProtKB/Swiss-Prot
    Q86Y54, Q8NDC4
    UniProtKB/TrEMBL
    A6XB87
    Conserved Domains (1) summary
    PLN03185
    Location:6 → 143
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

  2. NM_178832.4 → NP_849154.1  MORN repeat-containing protein 4

    See identical proteins and their annotated locations for NP_849154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AJ312050, AL834132
    Consensus CDS
    CCDS7468.1
    UniProtKB/Swiss-Prot
    Q86Y54, Q8NDC4
    UniProtKB/TrEMBL
    A6XB87
    Related
    ENSP00000307636.6, ENST00000307450.11
    Conserved Domains (1) summary
    PLN03185
    Location:6 → 143
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    97614555..97634156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539251.4 → XP_011537553.1  MORN repeat-containing protein 4 isoform X1

    See identical proteins and their annotated locations for XP_011537553.1

    UniProtKB/Swiss-Prot
    Q86Y54, Q8NDC4
    UniProtKB/TrEMBL
    A6XB87
    Conserved Domains (1) summary
    PLN03185
    Location:6 → 143
    PLN03185; phosphatidylinositol phosphate kinase; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    98494762..98514356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364722.1 → XP_054220697.1  MORN repeat-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q86Y54, Q8NDC4
    UniProtKB/TrEMBL
    A6XB87
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NDC4.1 GenPept UniProtKB/Swiss-Prot:Q8NDC4

Gene LinkOut

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