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Art5 ADP-ribosyltransferase 5 [ Mus musculus (house mouse) ]

Gene ID: 11875, updated on 3-Apr-2024

Summary

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Official Symbol
Art5provided by MGI
Official Full Name
ADP-ribosyltransferase 5provided by MGI
Primary source
MGI:MGI:107948
See related
Ensembl:ENSMUSG00000070424 AllianceGenome:MGI:107948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTC5; Yac-2
Summary
Enables NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. Acts upstream of or within protein ADP-ribosylation. Located in extracellular region and membrane. Is expressed in several structures, including heart; limb; male reproductive system; nose; and skeletal musculature. Orthologous to human ART5 (ADP-ribosyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 21.8), heart adult (RPKM 3.7) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Art5 in Genome Data Viewer
Location:
7 E2; 7 54.71 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101746086..101752052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102096879..102100291, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene STARR-seq mESC enhancer starr_19704 Neighboring gene nucleoporin 98 Neighboring gene STARR-seq mESC enhancer starr_19705 Neighboring gene post-GPI attachment to proteins 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, et al. J Biol Chem, 1996 Sep 6. PMID 8703012
  2. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article
  3. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC151200, MGC151226

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 5
Names
ADP-ribosyltransferase C2 and C3 toxin-like 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
mono(ADP-ribosyl)transferase 5
NP_001278283.1
NP_001398914.1
NP_001398915.1
NP_001398916.1
NP_001398917.1
NP_001398918.1
NP_001398919.1
NP_001398920.1
NP_001398921.1
NP_031517.2
XP_006507325.1
XP_006507326.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291354.2 → NP_001278283.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001278283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC132297
    Consensus CDS
    CCDS21525.1
    UniProtKB/Swiss-Prot
    E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
    UniProtKB/TrEMBL
    Q14AG6
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

  2. NM_001411985.1 → NP_001398914.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/Swiss-Prot
    E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
    Related
    ENSMUSP00000091678.3, ENSMUST00000094128.9

  3. NM_001411986.1 → NP_001398915.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297

  4. NM_001411987.1 → NP_001398916.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297

  5. NM_001411988.1 → NP_001398917.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    Related
    ENSMUSP00000102547.2, ENSMUST00000106934.2

  6. NM_001411989.1 → NP_001398918.1  ecto-ADP-ribosyltransferase 5 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297

  7. NM_001411990.1 → NP_001398919.1  ecto-ADP-ribosyltransferase 5 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC132297

  8. NM_001411991.1 → NP_001398920.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    B7ZMV7
    Related
    ENSMUSP00000102548.2, ENSMUST00000106935.8

  9. NM_001411992.1 → NP_001398921.1  ecto-ADP-ribosyltransferase 5 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    B7ZMV7

  10. NM_007491.3 → NP_031517.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_031517.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 4 all encode the same isoform (a).
    Source sequence(s)
    AC132297
    Consensus CDS
    CCDS21525.1
    UniProtKB/Swiss-Prot
    E9QM95, P70352, Q91VF7, Q91X06, Q91X07, Q921A5
    UniProtKB/TrEMBL
    Q14AG6
    Related
    ENSMUSP00000102550.2, ENSMUST00000106937.8
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 255
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_111935.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon and lacks an alternate internal segment compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132297

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101746086..101752052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507263.5 → XP_006507326.1  ecto-ADP-ribosyltransferase 5 isoform X6

    See identical proteins and their annotated locations for XP_006507326.1

    UniProtKB/Swiss-Prot
    P70352
    Conserved Domains (1) summary
    cl00173
    Location:29 → 119
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  2. XM_006507262.4 → XP_006507325.1  ecto-ADP-ribosyltransferase 5 isoform X5

    Conserved Domains (1) summary
    cl00173
    Location:29 → 160
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70352.3 GenPept UniProtKB/Swiss-Prot:P70352

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