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Art1 ADP-ribosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 11870, updated on 21-Apr-2024

Summary

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Official Symbol
Art1provided by MGI
Official Full Name
ADP-ribosyltransferase 1provided by MGI
Primary source
MGI:MGI:107511
See related
Ensembl:ENSMUSG00000030996 AllianceGenome:MGI:107511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADPRT; ARTC1; Yac-1
Summary
Enables NAD+ ADP-ribosyltransferase activity. Acts upstream of or within protein ADP-ribosylation. Located in cell surface. Is anchored component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human ART1 (ADP-ribosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 63.2), mammary gland adult (RPKM 11.5) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 E2; 7 54.71 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101750913..101771410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (102101706..102122062)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 binding protein Neighboring gene ring finger protein 121 Neighboring gene STARR-seq mESC enhancer starr_19703 Neighboring gene Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel, subfamily C, member 2 Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor, nicotinic, alpha polypeptide 10 Neighboring gene STARR-seq mESC enhancer starr_19704 Neighboring gene nucleoporin 98 Neighboring gene STARR-seq mESC enhancer starr_19705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:109358847-109359078 Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo. Xu JX, et al. Mol Med Rep, 2017 Mar. PMID 28138708, Free PMC Article
  2. ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-κB pathway. Xiao M, et al. Cell Physiol Biochem, 2013. PMID 24335275
  3. Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities. Bourgeois C, et al. J Biol Chem, 2003 Jul 18. PMID 12721285
  4. Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1α Pathway. Long WB, et al. Curr Med Sci, 2022 Aug. PMID 35798928
  5. Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme. Leutert M, et al. Cell Rep, 2018 Aug 14. PMID 30110646

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
    Title: ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
  2. High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus.
    Title: High Norepinephrine State Induces Growth of Colorectal Cancer Cells via ADP-Ribosyltransferase 1 in Type 2 Diabetes Mellitus.
  3. Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1alpha Pathway.
    Title: Arginine ADP-ribosyltransferase 1 Regulates Glycolysis in Colorectal Cancer via the PI3K/AKT/HIF1α Pathway.
  4. Proteomic characterization of the heart and skeletal muscle reveals widespread arginine ADP-ribosylation by the ARTC1 ectoenzyme with hemopexin being its target protein.
    Title: Proteomic Characterization of the Heart and Skeletal Muscle Reveals Widespread Arginine ADP-Ribosylation by the ARTC1 Ectoenzyme.
  5. The results demonstrated that ART1 gene silencing inhibited the growth of the spleen transplanted tumor and its ability to spread to the liver via metastasis.
    Title: Effect of ART1 on the proliferation and migration of mouse colon carcinoma CT26 cells in vivo.
  6. data suggest that ART1 promoted the expression of HIF-1alpha via the Akt pathway in tumor cells.
    Title: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
  7. the apoptosis rate in the ART1-cDNA CT26 cells treated with PARP-1 inhibitor 5-aminoisoquinoline (5-AIQ) and cisplatin increased, when compared with the ART1-cDNA CT26 cells treated with cisplatin only or the untreated ART1-cDNA CT26 cells.
    Title: Synergistic effect of arginine-specific ADP-ribosyltransferase 1 and poly(ADP-ribose) polymerase-1 on apoptosis induced by cisplatin in CT26 cells.
  8. ART1 knockdown reduced survival rate correlated with reduced levels of phos-Akt(Thr308) and phos-IkappaBalpha and reduced NF-kappaB p65 nuclear translocation.
    Title: ART1 silencing enhances apoptosis of mouse CT26 cells via the PI3K/Akt/NF-κB pathway.
  9. Successive amino- or carboxyl-terminal truncations of ART1, an arginine-specific transferase, identified regions that regulated transferase and NAD glycohydrolase activities.
    Title: Identification of regulatory domains in ADP-ribosyltransferase-1 that determine transferase and NAD glycohydrolase activities.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Names
ADP-ribosyltransferase C2 and C3 toxin-like 1
mono(ADP-ribosyl)transferase 1
NP_001398911.1
NP_033840.2
XP_011239959.1
XP_036008500.1
XP_036008501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411982.1 → NP_001398911.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132297
    UniProtKB/TrEMBL
    Q9D7F1
    Related
    ENSMUSP00000148204.2, ENSMUST00000210211.2

  2. NM_009710.5 → NP_033840.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033840.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC132297
    Consensus CDS
    CCDS21526.1
    UniProtKB/Swiss-Prot
    P70688, Q60935
    UniProtKB/TrEMBL
    Q545U9
    Related
    ENSMUSP00000033300.3, ENSMUST00000033300.4
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 269
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_177992.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC118592, AC132297

  2. NR_177993.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132297

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101750913..101771410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152608.1 → XP_036008501.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X2

    Conserved Domains (1) summary
    cl00173
    Location:39 → 179
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  2. XM_011241657.3 → XP_011239959.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011239959.1

    UniProtKB/Swiss-Prot
    P70688, Q60935
    UniProtKB/TrEMBL
    Q545U9
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 269
    ART; NAD:arginine ADP-ribosyltransferase

  3. XM_036152607.1 → XP_036008500.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P70688, Q60935
    UniProtKB/TrEMBL
    Q545U9
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 269
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. XR_869649.3 RNA Sequence

  2. XR_004933998.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60935.1 GenPept UniProtKB/Swiss-Prot:Q60935

Gene LinkOut

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