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Arhgdib Rho, GDP dissociation inhibitor beta [ Mus musculus (house mouse) ]

Gene ID: 11857, updated on 11-Apr-2024

Summary

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Official Symbol
Arhgdibprovided by MGI
Official Full Name
Rho, GDP dissociation inhibitor betaprovided by MGI
Primary source
MGI:MGI:101940
See related
Ensembl:ENSMUSG00000030220 AllianceGenome:MGI:101940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4; Gdid4; Ly-GDI
Summary
The protein encoded by this gene is a member of the Rho guanine nucleotide dissociation inhibitor (GDI) family. This gene is expressed at high levels in hematopoietic cells. This protein is cytosolic, and dissociation of Rho from this protein is required for membrane association and activation of Rho by Guanine Nucleotide Exchange Factors (GEFs). C-terminal truncations of this gene product have been reported to promote metastasis. Multiple transcript variants and protein isoforms exist. [provided by RefSeq, Aug 2014]
Expression
Biased expression in thymus adult (RPKM 157.4), spleen adult (RPKM 123.8) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgdib in Genome Data Viewer
Location:
6 G1; 6 66.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (136900653..136918895, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (136923655..136941899, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene matrix Gla protein Neighboring gene endoplasmic reticulum protein 27 Neighboring gene STARR-seq mESC enhancer starr_17614 Neighboring gene STARR-positive B cell enhancer ABC_E3690 Neighboring gene phosphodiesterase 6H, cGMP-specific, cone, gamma Neighboring gene STARR-positive B cell enhancer ABC_E9680 Neighboring gene STARR-positive B cell enhancer mm9_chr6:136929021-136929322 Neighboring gene predicted gene, 30055

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis. Yan C, et al. PLoS One, 2015. PMID 26469087, Free PMC Article
  2. GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells. Wang P, et al. Cancer Sci, 2011 Aug. PMID 21518140
  3. Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-beta with defective isoprenyl-binding pocket. Ota T, et al. Cell Biol Int, 2007 Jan. PMID 17049467
  4. Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling. Olofsson B. Cell Signal, 1999 Aug. PMID 10433515
  5. Immune responses in mice deficient in Ly-GDI, a lymphoid-specific regulator of Rho GTPases. Yin L, et al. Mol Immunol, 1997 Apr. PMID 9307064

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ly-GDI is a critical regulator of inflammatory injury after deposition of IgG immune complexes and that it negatively regulates the lung NF-kappaB activity.
    Title: Protective Role of Rho Guanosine Diphosphate Dissociation Inhibitor, Ly-GDI, in Pulmonary Alveolitis.
  2. these results indicate that RhoGDIbeta functions as a novel BMP4 signaling target that regulates adipogenesis and myogensis.
    Title: RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation.
  3. Rictor regulates cell migration by suppressing RhoGDI2.
    Title: Rictor regulates cell migration by suppressing RhoGDI2.
  4. Raptor siRNA suppressed the effects of GM3 on Ly-GDI expression and Akt phosphorylation at Thr(308) , suggesting GM3 signals to be transduced to mTOR-Raptor and Akt-Thr(308) , leading to Ly-GDI stimulation
    Title: GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor beta in melanoma B16 cells.
  5. Rho GDIalpha and Rho GDIbeta play synergistic roles in lymphocyte migration and development by modulating activation cycle of the Rho proteins in a lymphoid organ-specific manner.
    Title: Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta.
  6. Impaired interaction of RhoGDIbeta with Rac1 isoprenyl groups possibly makes RhoGDIbeta function as a positive regulator for Rac1 during metastasis.
    Title: Activation of Rac1 by Rho-guanine nucleotide dissociation inhibitor-beta with defective isoprenyl-binding pocket.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables Rho GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Rho GDP-dissociation inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho GDP-dissociation inhibitor 2
Names
Rho, GDP dissociation inhibitor (GDI) beta
rho GDI 2
rho-GDI beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301301.2 → NP_001288230.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288230.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000107522.2, ENSMUST00000111891.4
    Conserved Domains (1) summary
    pfam02115
    Location:7 → 197
    Rho_GDI; RHO protein GDP dissociation inhibitor

  2. NM_001301303.2 → NP_001288232.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288232.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:7 → 197
    Rho_GDI; RHO protein GDP dissociation inhibitor

  3. NM_001301305.2 → NP_001288234.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_001288234.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000107523.2, ENSMUST00000111892.8
    Conserved Domains (1) summary
    pfam02115
    Location:7 → 197
    Rho_GDI; RHO protein GDP dissociation inhibitor

  4. NM_001301308.2 → NP_001288237.1  rho GDP-dissociation inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_001288237.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:1 → 114
    Rho_GDI; RHO protein GDP dissociation inhibitor

  5. NM_001301309.2 → NP_001288238.1  rho GDP-dissociation inhibitor 2 isoform 2

    See identical proteins and their annotated locations for NP_001288238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the coding region and uses a downstream start codon compared to variant 1. Variants 5, 6, and 17-20 all encode isoform 2, which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:1 → 114
    Rho_GDI; RHO protein GDP dissociation inhibitor

  6. NM_001409490.1 → NP_001396419.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  7. NM_001409491.1 → NP_001396420.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  8. NM_001409492.1 → NP_001396421.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  9. NM_001409493.1 → NP_001396422.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  10. NM_001409494.1 → NP_001396423.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  11. NM_001409495.1 → NP_001396424.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  12. NM_001409497.1 → NP_001396426.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  13. NM_001409498.1 → NP_001396427.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  14. NM_001409499.1 → NP_001396428.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  15. NM_001409500.1 → NP_001396429.1  rho GDP-dissociation inhibitor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125341
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599

  16. NM_001409501.1 → NP_001396430.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341

  17. NM_001409502.1 → NP_001396431.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341

  18. NM_001409503.1 → NP_001396432.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341

  19. NM_001409504.1 → NP_001396433.1  rho GDP-dissociation inhibitor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125341

  20. NM_007486.6 → NP_031512.1  rho GDP-dissociation inhibitor 2 isoform 1

    See identical proteins and their annotated locations for NP_031512.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1-4 and 7-16 all encode the same isoform (1).
    Source sequence(s)
    AC125341
    Consensus CDS
    CCDS20661.1
    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Related
    ENSMUSP00000032344.6, ENSMUST00000032344.12
    Conserved Domains (1) summary
    pfam02115
    Location:7 → 197
    Rho_GDI; RHO protein GDP dissociation inhibitor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    136900653..136918895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255118.2 → XP_030110978.1  rho GDP-dissociation inhibitor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q3TEB3, Q61599
    Conserved Domains (1) summary
    pfam02115
    Location:7 → 197
    Rho_GDI; RHO protein GDP dissociation inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61599.3 GenPept UniProtKB/Swiss-Prot:Q61599

Gene LinkOut

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