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PRAP1 proline rich acidic protein 1 [ Homo sapiens (human) ]

Gene ID: 118471, updated on 7-Apr-2024

Summary

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Official Symbol
PRAP1provided by HGNC
Official Full Name
proline rich acidic protein 1provided by HGNC
Primary source
HGNC:HGNC:23304
See related
Ensembl:ENSG00000165828 MIM:609776; AllianceGenome:HGNC:23304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UPA; PRO1195
Summary
Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
10q26.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133347373..133352683)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134302524..134307799)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135160877..135166187)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4246 Neighboring gene calcyon neuron specific vesicular protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135148655-135149330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135169540-135170274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2976 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135172784-135172946 Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene microRNA 3944

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The proline-rich acidic protein is epigenetically regulated and inhibits growth of cancer cell lines. Zhang J, et al. Cancer Res, 2003 Oct 15. PMID 14583459
  2. Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis. Wolfarth AA, et al. Cell Mol Gastroenterol Hepatol, 2020. PMID 32629119, Free PMC Article
  3. ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells. Li M, et al. Gene, 2018 Sep 25. PMID 29886035
  4. Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma. Sze KM, et al. J Pathol, 2014 May. PMID 24374861
  5. PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage. Huang BH, et al. Cell Death Dis, 2012 Dec 13. PMID 23235459, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
    Title: Proline-Rich Acidic Protein 1 (PRAP1) Protects the Gastrointestinal Epithelium From Irradiation-Induced Apoptosis.
  2. ATF3 and PRAP1 play important roles in cisplatin-induced DNA damage repair process.
    Title: ATF3 and PRAP1 play important roles in cisplatin-induced damages in microvascular endothelial cells.
  3. PRAP1 is a protein interacting partner of MAD1 and that PRAP1 is able to down-regulate MAD1 and suppress mitotic checkpoint signalling in hepatocellular carcinoma.
    Title: Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma.
  4. Induction of PRAP1 expression by p53 in response to DNA-damaging agents contributes to cancer cell survival.
    Title: PRAP1 is a novel executor of p53-dependent mechanisms in cell survival after DNA damage.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF511-PRAP1

Readthrough gene: ZNF511-PRAP1, Included gene: ZNF511

Homology

Clone Names

  • MGC126792

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables triglyceride binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to X-ray ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in deactivation of mitotic spindle assembly checkpoint IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intestinal lipid absorption ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of triglyceride transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proline-rich acidic protein 1
Names
epididymis secretory sperm binding protein
epididymis tissue protein Li 178

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145201.2 → NP_001138673.1  proline-rich acidic protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001138673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AL360181, BC071872, DQ884405
    Consensus CDS
    CCDS44498.1
    UniProtKB/TrEMBL
    A0A384NL10, A6XND8
    Related
    ENSP00000486265.1, ENST00000463201.2
    Conserved Domains (1) summary
    pfam15314
    Location:96 → 140
    PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

  2. NM_145202.5 → NP_660203.3  proline-rich acidic protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_660203.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL360181, BC071872
    Consensus CDS
    CCDS7679.1
    UniProtKB/Swiss-Prot
    B7ZL57, B7ZL58, E9KL31, Q5VWY4, Q7Z4X5, Q8IWR3, Q8NCS2, Q96NZ9
    UniProtKB/TrEMBL
    A0A384NL10
    Related
    ENSP00000416126.2, ENST00000433452.6
    Conserved Domains (1) summary
    pfam15314
    Location:105 → 149
    PRAP; Proline-rich acidic protein 1, pregnancy-specific uterine

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133347373..133352683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134302524..134307799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96NZ9.2 GenPept UniProtKB/Swiss-Prot:Q96NZ9

Gene LinkOut

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