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Mrps2 mitochondrial ribosomal protein S2 [ Mus musculus (house mouse) ]

Gene ID: 118451, updated on 5-Mar-2024

Summary

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Official Symbol
Mrps2provided by MGI
Official Full Name
mitochondrial ribosomal protein S2provided by MGI
Primary source
MGI:MGI:2153089
See related
Ensembl:ENSMUSG00000035772 AllianceGenome:MGI:2153089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500019M10Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; heart; and liver. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 36. Orthologous to human MRPS2 (mitochondrial ribosomal protein S2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 23.2), adrenal adult (RPKM 20.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 19.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28355963..28361189)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28465951..28471177)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13373 Neighboring gene STARR-seq mESC enhancer starr_04019 Neighboring gene protein phosphatase 1, regulatory subunit 26 Neighboring gene STARR-seq mESC enhancer starr_04020 Neighboring gene piercer of microtubule wall 1 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_04022

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
  5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial ribosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS2m
Names
28S ribosomal protein S2, mitochondrial
MRP-S2
S2mt

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166031.2 → NP_001159503.2  small ribosomal subunit protein uS2m isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK051184, AK077219
    UniProtKB/TrEMBL
    Q8BQ99
    Conserved Domains (1) summary
    cd01425
    Location:62 → 237
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

  2. NM_080452.3 → NP_536700.3  small ribosomal subunit protein uS2m isoform 1

    See identical proteins and their annotated locations for NP_536700.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK051184, AK077219
    Consensus CDS
    CCDS15838.1
    UniProtKB/Swiss-Prot
    A2AK29, Q3TMF8, Q924T2
    UniProtKB/TrEMBL
    Q8BQ99
    Related
    ENSMUSP00000036725.4, ENSMUST00000038600.4
    Conserved Domains (1) summary
    cd01425
    Location:81 → 256
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28355963..28361189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497625.3 → XP_006497688.1  small ribosomal subunit protein uS2m isoform X1

    See identical proteins and their annotated locations for XP_006497688.1

    UniProtKB/TrEMBL
    Q8BQ99
    Conserved Domains (1) summary
    cd01425
    Location:127 → 302
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

  2. XM_030246830.1 → XP_030102690.1  small ribosomal subunit protein uS2m isoform X3

    Related
    ENSMUST00000146332.2
    Conserved Domains (1) summary
    cd01425
    Location:1 → 158
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

  3. XM_036157666.1 → XP_036013559.1  small ribosomal subunit protein uS2m isoform X2

    Conserved Domains (1) summary
    cd01425
    Location:3 → 160
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

  4. XM_036157667.1 → XP_036013560.1  small ribosomal subunit protein uS2m isoform X2

    Conserved Domains (1) summary
    cd01425
    Location:3 → 160
    RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924T2.1 GenPept UniProtKB/Swiss-Prot:Q924T2

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