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Arf3 ADP-ribosylation factor 3 [ Mus musculus (house mouse) ]

Gene ID: 11842, updated on 11-Apr-2024

Summary

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Official Symbol
Arf3provided by MGI
Official Full Name
ADP-ribosylation factor 3provided by MGI
Primary source
MGI:MGI:99432
See related
Ensembl:ENSMUSG00000051853 AllianceGenome:MGI:99432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5430400P17Rik
Summary
Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ARF3 (ADP ribosylation factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 216.8), cortex adult (RPKM 209.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arf3 in Genome Data Viewer
Location:
15 F1; 15 54.65 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98635505..98660999, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98737624..98763118, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 65 Neighboring gene FK506 binding protein 11 Neighboring gene uncharacterized LOC115488470 Neighboring gene wingless-type MMTV integration site family, member 10B Neighboring gene wingless-type MMTV integration site family, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Up-regulated ADP-Ribosylation factor 3 promotes breast cancer cell proliferation through the participation of FOXO1. Huang D, et al. Exp Cell Res, 2019 Nov 15. PMID 31539530
  2. ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking. Wu JY, et al. J Innate Immun, 2015. PMID 26067373, Free PMC Article
  3. Timing of androgen receptor disruption and estrogen exposure underlies a spectrum of congenital penile anomalies. Zheng Z, et al. Proc Natl Acad Sci U S A, 2015 Dec 29. PMID 26598695, Free PMC Article
  4. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
  5. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARF3 promotes breast cancer cell proliferation through the participation of FOXO1.
    Title: Up-regulated ADP-Ribosylation factor 3 promotes breast cancer cell proliferation through the participation of FOXO1.
  2. activated ARF3 is associated with Unc93B1 and TLR9, suggesting that ARF3 conducts TLR9 trafficking by forming the TLR9-Unc93B1-ARF3 complex.
    Title: ADP-Ribosylation Factor 3 Mediates Cytidine-Phosphate-Guanosine Oligodeoxynucleotide-Induced Responses by Regulating Toll-Like Receptor 9 Trafficking.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355510.1 → NP_001342439.1  ADP-ribosylation factor 3

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS27804.1
    UniProtKB/Swiss-Prot
    P61205
    UniProtKB/TrEMBL
    Q3U344
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_007478.3 → NP_031504.1  ADP-ribosylation factor 3

    See identical proteins and their annotated locations for NP_031504.1

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS27804.1
    UniProtKB/Swiss-Prot
    P61205
    UniProtKB/TrEMBL
    Q3U344
    Related
    ENSMUSP00000050689.10, ENSMUST00000053183.12
    Conserved Domains (1) summary
    cl38936
    Location:5 → 179
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98635505..98660999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61205.2 GenPept UniProtKB/Swiss-Prot:P61205

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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