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Aqr aquarius [ Mus musculus (house mouse) ]

Gene ID: 11834, updated on 21-Apr-2024

Summary

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Official Symbol
Aqrprovided by MGI
Official Full Name
aquariusprovided by MGI
Primary source
MGI:MGI:1276102
See related
Ensembl:ENSMUSG00000040383 AllianceGenome:MGI:1276102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0560
Summary
Predicted to enable 3'-5' RNA helicase activity; mRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of U2-type catalytic step 2 spliceosome. Orthologous to human AQR (aquarius intron-binding spliceosomal factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.8), limb E14.5 (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E4; 2 57.57 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (113931642..114005788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114101161..114175339, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene actin, alpha, cardiac muscle 1 divergent transcript Neighboring gene predicted gene, 46757 Neighboring gene predicted gene, 54143 Neighboring gene VISTA enhancer mm182 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113971248-113971549 Neighboring gene STARR-positive B cell enhancer ABC_E1593 Neighboring gene STARR-seq mESC enhancer starr_05403 Neighboring gene microRNA 7002 Neighboring gene zinc finger protein 770 Neighboring gene STARR-seq mESC enhancer starr_05404 Neighboring gene STARR-seq mESC enhancer starr_05405 Neighboring gene STARR-seq mESC enhancer starr_05406 Neighboring gene STARR-seq mESC enhancer starr_05407 Neighboring gene STARR-seq mESC enhancer starr_05408 Neighboring gene STARR-seq mESC enhancer starr_05409 Neighboring gene predicted gene, 31146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aquarius, a novel gene isolated by gene trapping with an RNA-dependent RNA polymerase motif. Sam M, et al. Dev Dyn, 1998 Jun. PMID 9626505
  2. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Forrester LM, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643689, Free PMC Article
  3. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' RNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA helicase aquarius
Names
intron-binding protein aquarius
intron-binding protein of 160 kDa
NP_001277717.1
NP_001403810.1
NP_001403811.1
NP_001403813.1
NP_001403814.1
NP_001403815.1
NP_001403816.1
NP_001403818.1
NP_001403819.1
NP_033832.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290788.2 → NP_001277717.1  RNA helicase aquarius isoform b

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569
    Consensus CDS
    CCDS71114.1
    UniProtKB/TrEMBL
    A2AQA7
    Related
    ENSMUSP00000099602.5, ENSMUST00000102543.5
    Conserved Domains (4) summary
    pfam13086
    Location:805 → 1111
    AAA_11; AAA domain
    pfam13245
    Location:808 → 880
    AAA_19; Part of AAA domain
    pfam16399
    Location:18 → 802
    Aquarius_N; Intron-binding protein aquarius N-terminus
    cl22977
    Location:1119 → 1308
    UvrD_C_2; UvrD-like helicase C-terminal domain

  2. NM_001416881.1 → NP_001403810.1  RNA helicase aquarius isoform c

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569

  3. NM_001416882.1 → NP_001403811.1  RNA helicase aquarius isoform d

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569

  4. NM_001416884.1 → NP_001403813.1  RNA helicase aquarius isoform g

    Status: VALIDATED

    Source sequence(s)
    AL844569

  5. NM_001416885.1 → NP_001403814.1  RNA helicase aquarius isoform h

    Status: VALIDATED

    Source sequence(s)
    AL844569

  6. NM_001416886.1 → NP_001403815.1  RNA helicase aquarius isoform i

    Status: VALIDATED

    Source sequence(s)
    AL844569
    Related
    ENSMUST00000129504.8

  7. NM_001416887.1 → NP_001403816.1  RNA helicase aquarius isoform j

    Status: VALIDATED

    Source sequence(s)
    AL844569

  8. NM_001416889.1 → NP_001403818.1  RNA helicase aquarius isoform e

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569

  9. NM_001416890.1 → NP_001403819.1  RNA helicase aquarius isoform f

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569

  10. NM_009702.4 → NP_033832.2  RNA helicase aquarius isoform a

    See identical proteins and their annotated locations for NP_033832.2

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569
    Consensus CDS
    CCDS16565.1
    UniProtKB/Swiss-Prot
    P97871, Q3U9N1, Q3ULE8, Q80TX8, Q8CFQ3
    Related
    ENSMUSP00000047157.7, ENSMUST00000043160.13
    Conserved Domains (4) summary
    pfam13086
    Location:805 → 1111
    AAA_11; AAA domain
    pfam13245
    Location:808 → 880
    AAA_19; Part of AAA domain
    pfam16399
    Location:18 → 802
    Aquarius_N; Intron-binding protein aquarius N-terminus
    cl22977
    Location:1119 → 1308
    UvrD_C_2; UvrD-like helicase C-terminal domain

RNA

  1. NR_184400.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC133157, AL844569

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    113931642..114005788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFQ3.2 GenPept UniProtKB/Swiss-Prot:Q8CFQ3

Gene LinkOut

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