U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Xiap X-linked inhibitor of apoptosis [ Mus musculus (house mouse) ]

Gene ID: 11798, updated on 21-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Xiapprovided by MGI
Official Full Name
X-linked inhibitor of apoptosisprovided by MGI
Primary source
MGI:MGI:107572
See related
Ensembl:ENSMUSG00000025860 AllianceGenome:MGI:107572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik
Summary
The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
X A4; X 23.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41148483..41198541)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42059613..42109664)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47056 Neighboring gene N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits pseudogene Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47057 Neighboring gene STARR-seq mESC enhancer starr_47058 Neighboring gene STARR-seq mESC enhancer starr_47060 Neighboring gene STARR-positive B cell enhancer ABC_E9459 Neighboring gene zinc finger protein 7 pseudogene Neighboring gene STAG2 cohesin complex component

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury. Reigada D, et al. Int J Mol Sci, 2023 Feb 1. PMID 36769152, Free PMC Article
  2. Overexpression of XIAP inhibits cisplatin-induced hair cell loss. Li Y, et al. Biochim Biophys Acta Mol Cell Res, 2022 Apr. PMID 35026350
  3. XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC. He L, et al. Front Physiol, 2021. PMID 34025452, Free PMC Article
  4. XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway. Gao D, et al. Biochem Pharmacol, 2021 Apr. PMID 33713642
  5. Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress. Zilu S, et al. Aging (Albany NY), 2019 Dec 16. PMID 31841118, Free PMC Article

See all (164) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
    Title: XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
  2. Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.
    Title: Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.
  3. XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
    Title: XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
  4. Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
    Title: Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
  5. XIAP prevents TNF-driven inflammation in the terminal ileum of mice. In Xiap-/- mice, TNFR1 signaling kills Paneth cells and TNFR1/TNFR2 signaling kills dendritic cells. Together this drives dysbiosis.
    Title: XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
  6. MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.
    Title: MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.
  7. XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
    Title: XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
  8. Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.
    Title: Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.
  9. SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
    Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
  10. Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.
    Title: Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.
Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inhibition of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptosis involved in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase XIAP
Names
IAP homolog A
RING-type E3 ubiquitin transferase XIAP
X-linked IAP
baculoviral IAP repeat-containing protein 4
inhibitor of apoptosis protein 3
NP_001288568.1
NP_001288570.1
NP_033818.2
XP_006541488.1
XP_006541490.1
XP_011249278.1
XP_011249279.1
XP_017173848.1
XP_017173849.1
XP_017173850.1
XP_017173851.1
XP_030107060.1
XP_030107062.1
XP_030107063.1
XP_036017678.1
XP_036017679.1
XP_036017680.1
XP_036017681.1
XP_036017682.1
XP_036017683.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301639.1 → NP_001288568.1  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_001288568.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000110747.3, ENSMUST00000115095.9
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  2. NM_001301641.1 → NP_001288570.1  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_001288570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, BX530028, CD548741, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000061074.4, ENSMUST00000055483.10
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  3. NM_009688.3 → NP_033818.2  E3 ubiquitin-protein ligase XIAP

    See identical proteins and their annotated locations for NP_033818.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CJ111937, CJ126958, CK389763, CN527460, CN535777
    Consensus CDS
    CCDS30098.1
    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Related
    ENSMUSP00000110746.2, ENSMUST00000115094.8
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

RNA

  1. NR_125870.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AI848625, AK041844, AK147447, BB663325, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777
    Related
    ENSMUST00000145065.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    41148483..41198541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318359.3 → XP_017173848.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  2. XM_017318362.3 → XP_017173851.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  3. XM_017318360.3 → XP_017173849.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  4. XM_030251203.2 → XP_030107063.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  5. XM_036161787.1 → XP_036017680.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  6. XM_036161786.1 → XP_036017679.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  7. XM_030251202.2 → XP_030107062.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  8. XM_036161788.1 → XP_036017681.1  E3 ubiquitin-protein ligase XIAP isoform X3

    Conserved Domains (3) summary
    smart00238
    Location:214 → 284
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:80 → 147
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:421 → 470
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  9. XM_011250976.4 → XP_011249278.1  E3 ubiquitin-protein ligase XIAP isoform X1

    Conserved Domains (4) summary
    smart00238
    Location:214 → 284
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:80 → 147
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:421 → 470
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:487 → 548
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  10. XM_036161790.1 → XP_036017683.1  E3 ubiquitin-protein ligase XIAP isoform X4

    Conserved Domains (3) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  11. XM_017318361.2 → XP_017173850.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  12. XM_006541427.3 → XP_006541490.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_006541490.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  13. XM_006541425.3 → XP_006541488.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_006541488.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  14. XM_036161785.1 → XP_036017678.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  15. XM_030251200.2 → XP_030107060.1  E3 ubiquitin-protein ligase XIAP isoform X2

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  16. XM_036161789.1 → XP_036017682.1  E3 ubiquitin-protein ligase XIAP isoform X4

    Conserved Domains (3) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

  17. XM_011250977.4 → XP_011249279.1  E3 ubiquitin-protein ligase XIAP isoform X2

    See identical proteins and their annotated locations for XP_011249279.1

    UniProtKB/Swiss-Prot
    A2BGY6, O08865, Q60989
    Conserved Domains (4) summary
    smart00238
    Location:162 → 232
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:28 → 95
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14395
    Location:369 → 418
    UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
    cd16714
    Location:435 → 496
    RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60989.2 GenPept UniProtKB/Swiss-Prot:Q60989

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous