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Apbb2 amyloid beta precursor protein binding family B member 2 [ Mus musculus (house mouse) ]

Gene ID: 11787, updated on 11-Apr-2024

Summary

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Official Symbol
Apbb2provided by MGI
Official Full Name
amyloid beta precursor protein binding family B member 2provided by MGI
Primary source
MGI:MGI:108405
See related
Ensembl:ENSMUSG00000029207 AllianceGenome:MGI:108405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TR2L; Zfra; Rirl1; FE65L1; 2310007D03Rik
Summary
Predicted to enable amyloid-beta binding activity. Involved in maintenance of lens transparency and smooth muscle contraction. Acts upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 2.9), cerebellum adult (RPKM 2.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Apbb2 in Genome Data Viewer
Location:
5 C3.1; 5 34.43 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66456068..66779189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66298725..66619064, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene NOL1/NOP2/Sun domain family, member 7 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_13303 Neighboring gene STARR-seq mESC enhancer starr_13304 Neighboring gene ubiquitin carboxy-terminal hydrolase L1 Neighboring gene STARR-seq mESC enhancer starr_13305 Neighboring gene LIM and calponin homology domains 1 Neighboring gene STARR-seq mESC enhancer starr_13306 Neighboring gene predicted gene 6517

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing. Suh J, et al. J Neurochem, 2011 Oct. PMID 21824144, Free PMC Article
  2. Characterization of an apoptosis inhibitory domain at the C-termini of FE65-like protein. Cao H, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027557
  3. Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration. Lin YH, et al. Int J Mol Sci, 2022 Nov 22. PMID 36498839, Free PMC Article
  4. FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness. Suh J, et al. FASEB J, 2015 Jun. PMID 25757569, Free PMC Article
  5. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode. Li H, et al. J Biol Chem, 2008 Oct 3. PMID 18650440

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfra Inhibits the TRAPPC6ADelta-Initiated Pathway of Neurodegeneration.
    Title: Zfra Inhibits the TRAPPC6AΔ-Initiated Pathway of Neurodegeneration.
  2. These data demonstrate a role for FE65 proteins at central and peripheral synapses.
    Title: FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.
  3. Findings show that amyloid precursor protein-binding proteins FE65 and FE65L1 are essential for the maintenance of lens transparency.
    Title: FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.
  4. FE65 proteins contribute to physiological APP processing and accumulation of amyloid precursor protein metabolic products resulting from NMDA receptor activation
    Title: FE65 proteins regulate NMDA receptor activation-induced amyloid precursor protein processing.
  5. Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode
    Title: Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode.
  6. Targeted deletion of two members of the FE65 family of adaptor proteins, FE65 and FE65L1, results in cortical dysplasia and suggests that FE65 proteins are involved in basement membrane assembly.
    Title: Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
  7. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF
    Title: The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor.
  8. While mitogen activated protein kinase 8 (JNK1) is a downstream effector of the Tumor Necrosis Factor (TNF) signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1.
    Title: Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in maintenance of lens transparency IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid beta precursor protein binding family B member 2
Names
amyloid beta (A4) precursor protein-binding, family B, member 2
protein Fe65-like 1
zinc finger-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201413.2 → NP_001188342.1  amyloid beta precursor protein binding family B member 2 isoform 2

    See identical proteins and their annotated locations for NP_001188342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS57345.1
    UniProtKB/TrEMBL
    E9QPX0, Q3TIZ5
    Related
    ENSMUSP00000123978.3, ENSMUST00000160870.8
    Conserved Domains (3) summary
    cd01271
    Location:582 → 708
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416 → 553
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  2. NM_001201414.2 → NP_001188343.1  amyloid beta precursor protein binding family B member 2 isoform 3

    See identical proteins and their annotated locations for NP_001188343.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS57346.1
    UniProtKB/TrEMBL
    E9PWH3, Q3U674
    Related
    ENSMUSP00000124807.2, ENSMUST00000159512.8
    Conserved Domains (3) summary
    cd01271
    Location:562 → 688
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396 → 533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  3. NM_001201415.2 → NP_001188344.1  amyloid beta precursor protein binding family B member 2 isoform 4

    See identical proteins and their annotated locations for NP_001188344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS57344.1
    UniProtKB/TrEMBL
    Q3U674
    Related
    ENSMUSP00000125211.3, ENSMUST00000159786.8
    Conserved Domains (3) summary
    cd01271
    Location:561 → 687
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  4. NM_001201416.1 → NP_001188345.1  amyloid beta precursor protein binding family B member 2 isoform 5

    See identical proteins and their annotated locations for NP_001188345.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks multiple coding exons from the 5' end and has an alternate 5' exon compared to variant 1. It initiates translation at a downstream start codon. The resulting isoform (5) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC131752
    UniProtKB/TrEMBL
    Q3T9N0
    Related
    ENSMUST00000162955.8
    Conserved Domains (1) summary
    cd01271
    Location:34 → 160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

  5. NM_001310626.2 → NP_001297555.1  amyloid beta precursor protein binding family B member 2 isoform 6

    See identical proteins and their annotated locations for NP_001297555.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS80292.1
    UniProtKB/TrEMBL
    Q3TDW6, Q3U674
    Related
    ENSMUSP00000125116.2, ENSMUST00000162366.8
    Conserved Domains (3) summary
    cd01271
    Location:560 → 686
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  6. NM_009686.3 → NP_033816.1  amyloid beta precursor protein binding family B member 2 isoform 1

    See identical proteins and their annotated locations for NP_033816.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC123049, AC131752, AC149587, AC165426
    Consensus CDS
    CCDS51510.1
    UniProtKB/Swiss-Prot
    Q6DFX8, Q9DBR4
    UniProtKB/TrEMBL
    E9QPX0
    Related
    ENSMUSP00000123752.3, ENSMUST00000162349.8
    Conserved Domains (3) summary
    cd01271
    Location:584 → 710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416 → 555
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66456068..66779189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503696.5 → XP_006503759.1  amyloid beta precursor protein binding family B member 2 isoform X13

    See identical proteins and their annotated locations for XP_006503759.1

    UniProtKB/TrEMBL
    Q3T9N0
    Conserved Domains (1) summary
    cd01271
    Location:34 → 160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

  2. XM_006503697.5 → XP_006503760.1  amyloid beta precursor protein binding family B member 2 isoform X13

    See identical proteins and their annotated locations for XP_006503760.1

    UniProtKB/TrEMBL
    Q3T9N0
    Conserved Domains (1) summary
    cd01271
    Location:34 → 160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

  3. XM_036164748.1 → XP_036020641.1  amyloid beta precursor protein binding family B member 2 isoform X9

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:561 → 687
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  4. XM_030254081.2 → XP_030109941.1  amyloid beta precursor protein binding family B member 2 isoform X7

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:563 → 689
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 534
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  5. XM_030254078.2 → XP_030109938.1  amyloid beta precursor protein binding family B member 2 isoform X2

    UniProtKB/Swiss-Prot
    Q6DFX8, Q9DBR4
    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:584 → 710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416 → 555
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  6. XM_006503691.5 → XP_006503754.1  amyloid beta precursor protein binding family B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006503754.1

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:585 → 711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  7. XM_030254079.2 → XP_030109939.1  amyloid beta precursor protein binding family B member 2 isoform X2

    UniProtKB/Swiss-Prot
    Q6DFX8, Q9DBR4
    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:584 → 710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:416 → 555
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  8. XM_006503690.5 → XP_006503753.1  amyloid beta precursor protein binding family B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006503753.1

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:585 → 711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  9. XM_030254080.2 → XP_030109940.1  amyloid beta precursor protein binding family B member 2 isoform X7

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:563 → 689
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 534
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  10. XM_030254082.2 → XP_030109942.1  amyloid beta precursor protein binding family B member 2 isoform X10

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:561 → 687
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396 → 533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  11. XM_006503694.5 → XP_006503757.1  amyloid beta precursor protein binding family B member 2 isoform X8

    See identical proteins and their annotated locations for XP_006503757.1

    UniProtKB/TrEMBL
    E9PWH3, Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:562 → 688
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396 → 533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  12. XM_006503693.5 → XP_006503756.1  amyloid beta precursor protein binding family B member 2 isoform X6

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:564 → 690
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396 → 535
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  13. XM_006503692.5 → XP_006503755.1  amyloid beta precursor protein binding family B member 2 isoform X5

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:582 → 708
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 554
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  14. XM_017320620.3 → XP_017176109.1  amyloid beta precursor protein binding family B member 2 isoform X4

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:583 → 709
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 554
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  15. XM_011240693.4 → XP_011238995.1  amyloid beta precursor protein binding family B member 2 isoform X3

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:584 → 710
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  16. XM_006503688.5 → XP_006503751.1  amyloid beta precursor protein binding family B member 2 isoform X1

    See identical proteins and their annotated locations for XP_006503751.1

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:585 → 711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  17. XM_036164747.1 → XP_036020640.1  amyloid beta precursor protein binding family B member 2 isoform X7

    UniProtKB/TrEMBL
    Q3U674
    Conserved Domains (3) summary
    cd01271
    Location:563 → 689
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 534
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  18. XM_036164746.1 → XP_036020639.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01271
    Location:585 → 711
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  19. XM_017320622.3 → XP_017176111.1  amyloid beta precursor protein binding family B member 2 isoform X12

    Conserved Domains (3) summary
    cd01271
    Location:311 → 437
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:143 → 282
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:19 → 47
    WW; WW domain

  20. XM_036164749.1 → XP_036020642.1  amyloid beta precursor protein binding family B member 2 isoform X11

    UniProtKB/TrEMBL
    E9QPX0
    Conserved Domains (3) summary
    cd01272
    Location:417 → 556
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain
    cl17171
    Location:585 → 647
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBR4.2 GenPept UniProtKB/Swiss-Prot:Q9DBR4

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