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Ap1g1 adaptor protein complex AP-1, gamma 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 11765, updated on 11-Apr-2024

Summary

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Official Symbol
Ap1g1provided by MGI
Official Full Name
adaptor protein complex AP-1, gamma 1 subunitprovided by MGI
Primary source
MGI:MGI:101919
See related
Ensembl:ENSMUSG00000031731 AllianceGenome:MGI:101919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adtg; D8Ertd374e
Summary
Predicted to enable several functions, including GTP-dependent protein binding activity; clathrin adaptor activity; and kinesin binding activity. Predicted to be involved in several processes, including Golgi to lysosome transport; endosome to melanosome transport; and positive regulation of natural killer cell degranulation. Predicted to act upstream of or within intracellular protein transport and vesicle-mediated transport. Located in perinuclear region of cytoplasm and trans-Golgi network. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human AP1G1 (adaptor related protein complex 1 subunit gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 17.8), CNS E18 (RPKM 17.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 D3; 8 57.26 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110505215..110590842)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109778583..109864210)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112261750-112261859 Neighboring gene STARR-seq mESC enhancer starr_22658 Neighboring gene ataxin 1-like Neighboring gene STARR-seq mESC enhancer starr_22659 Neighboring gene STARR-seq mESC enhancer starr_22660 Neighboring gene predicted gene, 51550 Neighboring gene La ribonucleoprotein domain family, member 1B pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112302310-112302493 Neighboring gene STARR-seq mESC enhancer starr_22661 Neighboring gene predicted gene, 17344 Neighboring gene small nucleolar RNA, C/D box 71 Neighboring gene predicted gene, 25321 Neighboring gene PH domain and leucine rich repeat protein phosphatase 2 Neighboring gene STARR-seq mESC enhancer starr_22662 Neighboring gene STARR-positive B cell enhancer ABC_E6682 Neighboring gene STARR-positive B cell enhancer ABC_E6683 Neighboring gene STARR-positive B cell enhancer ABC_E10522 Neighboring gene STARR-positive B cell enhancer ABC_E8263 Neighboring gene MARVEL (membrane-associating) domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice. Johnson KR, et al. Mamm Genome, 2016 Jun. PMID 27090238, Free PMC Article
  2. Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis. Lefkir Y, et al. Mol Biol Cell, 2004 Feb. PMID 14617812, Free PMC Article
  3. Early embryonic death of mice deficient in gamma-adaptin. Zizioli D, et al. J Biol Chem, 1999 Feb 26. PMID 10026148
  4. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. Robinson MS. J Cell Biol, 1990 Dec. PMID 2126014, Free PMC Article
  5. Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin. Kent HM, et al. Structure, 2002 Aug. PMID 12176391

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ap1g1 (fgt) mutant mice provide a new animal model to study the in vivo roles of gamma-1 adaptin and the AP-1 complex throughout development and to investigate factors that underlie its associated phenotypic abnormalities
    Title: A hypomorphic mutation of the gamma-1 adaptin gene (Ap1g1) causes inner ear, retina, thyroid, and testes abnormalities in mice.
  2. 1.8 A resolution structure and binding site for Eps15 and gamma-synergin is presented
    Title: Gamma-adaptin appendage domain: structure and binding site for Eps15 and gamma-synergin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basolateral protein secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in endosome to melanosome transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in melanosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet dense granule organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of natural killer cell degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
AP-1 complex subunit gamma-1
Names
adapter-related protein complex 1 subunit gamma-1
adaptor protein complex AP-1 subunit gamma-1
adaptor-related protein complex 1 subunit gamma-1
clathrin assembly protein complex 1 gamma-1 large chain
gamma-adaptin
gamma1-adaptin
golgi adaptor HA1/AP1 adaptin subunit gamma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301211.1 → NP_001288140.1  AP-1 complex subunit gamma-1 isoform 2

    See identical proteins and their annotated locations for NP_001288140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC122807, BU755831, BY738987, X54424
    Consensus CDS
    CCDS80929.1
    UniProtKB/Swiss-Prot
    P22892
    UniProtKB/TrEMBL
    Q3UKX8
    Related
    ENSMUSP00000034171.9, ENSMUST00000034171.9
    Conserved Domains (4) summary
    smart00809
    Location:709 → 817
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam05109
    Location:590 → 702
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:142 → 163
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:23 → 574
    Adaptin_N; Adaptin N terminal region

  2. NM_009677.6 → NP_033807.2  AP-1 complex subunit gamma-1 isoform 1

    See identical proteins and their annotated locations for NP_033807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC122807, AK036387, BU755831, BY738987
    Consensus CDS
    CCDS40475.1
    UniProtKB/TrEMBL
    Q3UKX8, Q8CBB7
    Related
    ENSMUSP00000090844.7, ENSMUST00000093157.13
    Conserved Domains (4) summary
    smart00809
    Location:712 → 820
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam05109
    Location:593 → 705
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:142 → 163
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:23 → 577
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110505215..110590842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22892.3 GenPept UniProtKB/Swiss-Prot:P22892

Gene LinkOut

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