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B3galt6 UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 [ Mus musculus (house mouse) ]

Gene ID: 117592, updated on 30-Apr-2024

Summary

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Official Symbol
B3galt6provided by MGI
Official Full Name
UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6provided by MGI
Primary source
MGI:MGI:2152819
See related
Ensembl:ENSMUSG00000050796 AllianceGenome:MGI:2152819
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GalTII
Summary
Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within glycosaminoglycan biosynthetic process. Located in Golgi medial cisterna. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome spondylodysplastic type 2 and spondyloepimetaphyseal dysplasia with joint laxity type 1. Orthologous to human B3GALT6 (beta-1,3-galactosyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 87.66 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156073923..156077135, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155989466..155992678, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10298 Neighboring gene STARR-seq mESC enhancer starr_12277 Neighboring gene ubiquitin-conjugating enzyme E2J 2 Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene stromal cell derived factor 4 Neighboring gene tumor necrosis factor receptor superfamily, member 4 Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A quantitative study of the Golgi retention of glycosyltransferases. Sun X, et al. J Cell Sci, 2021 Oct 15. PMID 34533190
  2. Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6). Bai X, et al. J Biol Chem, 2001 Dec 21. PMID 11551958
  3. Strain-specific modifier genes governing craniofacial phenotypes. Mukhopadhyay P, et al. Birth Defects Res A Clin Mol Teratol, 2012 Mar. PMID 22371338, Free PMC Article
  4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC91010

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactosylxylosylprotein 3-beta-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycosaminoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycosaminoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in proteoglycan biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi medial cisterna ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-galactosyltransferase 6
Names
GAG GalTII
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 6
beta-1,3-GalTase 6
beta3Gal-T6
beta3GalT6
galactosyltransferase II
galactosylxylosylprotein 3-beta-galactosyltransferase
NP_536693.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080445.4 → NP_536693.1  beta-1,3-galactosyltransferase 6 precursor

    See identical proteins and their annotated locations for NP_536693.1

    Status: VALIDATED

    Source sequence(s)
    AK033608, AK078083, BB660643
    Consensus CDS
    CCDS19053.1
    UniProtKB/Swiss-Prot
    Q8CC93, Q91Z92
    Related
    ENSMUSP00000057521.4, ENSMUST00000052185.5
    Conserved Domains (1) summary
    cl21608
    Location:65 → 256
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156073923..156077135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91Z92.1 GenPept UniProtKB/Swiss-Prot:Q91Z92

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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