Aoc3 amine oxidase, copper containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aoc3provided by MGI
Official Full Name: amine oxidase, copper containing 3provided by MGI
Primary source: MGI:MGI:1306797
See related: Ensembl:ENSMUSG00000019326 AllianceGenome:MGI:1306797
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SSAO; VAP1
Summary: Predicted to enable several functions, including metal ion binding activity; primary amine oxidase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including leukocyte migration involved in inflammatory response; negative regulation of primary amine oxidase activity; and positive regulation of glucose transmembrane transport. Predicted to be located in several cellular components, including cell surface; extracellular space; and microvillus. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; axial skeleton; cardiovascular system; sensory organ; and skin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 188.2), genital fat pad adult (RPKM 119.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 64.72 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (101221432..101230256)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (101330606..101339430)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction.
Title: Amine oxidase copper-containing 3 aggravates cardiac remodelling by generating hydrogen peroxide after myocardial infarction.
Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
Title: Obesity of mice lacking VAP-1/SSAO by Aoc3 gene deletion is reproduced in mice expressing a mutated vascular adhesion protein-1 (VAP-1) devoid of amine oxidase activity.
Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1.
Title: Comparison of Inhibitor and Substrate Selectivity between Rodent and Human Vascular Adhesion Protein-1.
The results establish a role for Copper homeostasis in adipocyte metabolism and identify SSAO as a regulator of energy utilization processes in adipocytes.
Title: Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes.
The blockade of VAP-1 could be a promising medical modality to combat the acute and chronic variants.
Title: Inhibition of Vascular Adhesion Protein-1 for Treatment of Graft-Versus-Host Disease in Mice.
Data indicate strong-to-moderate expression of vascular adhesion protein-1 (VAP-1) in the synovium of Borrelia burgdorferi-infected mice, while only weak expression of VAP-1 was detected in uninfected mice.
Title: Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice.
VAP-1 was expressed on endothelial cells lining inflamed atherosclerotic lesions; normal vessel walls in aortas of C57BL/6N control mice were VAP-1-negative.
Title: Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques.
VAP-1 plays a critical role in the pathophysiology of renal ischemia/reperfusion injury by enhancement of neutrophil infiltration generating a local hydrogen peroxide gradient.
Title: Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
This study showed that the oxidase activity of AOC3 contributes to the development of lung fibrosis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic response.
Title: Amine oxidase activity regulates the development of pulmonary fibrosis.
data indicate that SSAO inactivation in vivo stabilizes the established plaques mainly via inducing the switch of SMCs from a contractile to a synthetic phenotype
Title: Inactivation of Semicarbazide-Sensitive Amine Oxidase Stabilizes the Established Atherosclerotic Lesions via Inducing the Phenotypic Switch of Smooth Muscle Cells.

Submit: New GeneRIF Correction See all GeneRIFs (35)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Aoc3 (e-PCR), detects polymorphism
- UniSTS:546655

AF054831 (e-PCR)
- UniSTS:160166

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aliphatic amine oxidase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables primary amine oxidase activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables quinone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in amine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of primary amine oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to immobilization stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: membrane primary amine oxidase

Names: VAP-1; copper amine oxidase; semicarbazide-sensitive amine oxidase; vascular adhesion protein 1

NP_033805.1

EC 1.4.3.21

XP_006532104.1

EC 1.4.3.21

XP_017169719.1

EC 1.4.3.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009675.2 → NP_033805.1 membrane primary amine oxidase

See identical proteins and their annotated locations for NP_033805.1

Status: VALIDATED

Source sequence(s)

AL590969

Consensus CDS

CCDS25465.1

UniProtKB/Swiss-Prot

A2A4I7, O70423, Q66JM4, Q9R055

Related

ENSMUSP00000099394.4, ENSMUST00000103105.10

Conserved Domains (3) summary

pfam01179
Location:315 → 721

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02727
Location:66 → 152

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam02728
Location:169 → 269

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

101221432..101230256

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532041.5 → XP_006532104.1 membrane primary amine oxidase isoform X2

Conserved Domains (1) summary

pfam01179
Location:7 → 178

Cu_amine_oxid; Copper amine oxidase, enzyme domain
XM_017314230.2 → XP_017169719.1 membrane primary amine oxidase isoform X1

Conserved Domains (1) summary

pfam01179
Location:11 → 196

Cu_amine_oxid; Copper amine oxidase, enzyme domain