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Ank3 ankyrin 3, epithelial [ Mus musculus (house mouse) ]

Gene ID: 11735, updated on 13-Apr-2024

Summary

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Official Symbol
Ank3provided by MGI
Official Full Name
ankyrin 3, epithelialprovided by MGI
Primary source
MGI:MGI:88026
See related
Ensembl:ENSMUSG00000069601 AllianceGenome:MGI:88026
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AnkG; Ank-3; Ankyrin-3; Ankyrin-G; 2900054D09Rik
Summary
This gene encodes a member of the ankyrin protein family. Ankyrins link integral membrane proteins to the spectrin-based cytoskeleton. Ankyrin family members share a protein structure which includes three independently folded domains: the N-terminal ankyrin repeat domain, the central spectrin-binding domain, and the C-terminal rod domain. This ankyrin functions as the major ankyrin in the kidney and may play a role in the polarized distribution of many integral membrane proteins to specific subcellular sites. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in cerebellum adult (RPKM 12.9), CNS E18 (RPKM 10.5) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Ank3 in Genome Data Viewer
Location:
10 B5.3; 10 36.1 cM
Exon count:
57
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (69234608..69863266)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (69533486..70027436)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930423B08 gene Neighboring gene STARR-positive B cell enhancer ABC_E6871 Neighboring gene STARR-seq mESC enhancer starr_27056 Neighboring gene cyclin dependent kinase 1 Neighboring gene STARR-seq mESC enhancer starr_27058 Neighboring gene suppression of tumorigenicity 13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27059 Neighboring gene predicted gene, 51806 Neighboring gene predicted gene, 33464 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_27062 Neighboring gene STARR-seq mESC enhancer starr_27063 Neighboring gene predicted gene, 33416 Neighboring gene predicted gene, 33361 Neighboring gene STARR-seq mESC enhancer starr_27068 Neighboring gene STARR-seq mESC enhancer starr_27069 Neighboring gene STARR-positive B cell enhancer ABC_E5146 Neighboring gene STARR-seq mESC enhancer starr_27073 Neighboring gene predicted gene, 51771 Neighboring gene coiled-coil domain containing 6 Neighboring gene myoregulin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment. Wang Y, et al. Biochem Biophys Res Commun, 2021 Nov 12. PMID 34534742
  2. Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na(+) channel. Abd El-Aziz TM, et al. Sci Rep, 2021 Jul 16. PMID 34272444, Free PMC Article
  3. Giant ankyrin-G regulates cardiac function. Cavus O, et al. J Biol Chem, 2021 Jan-Jun. PMID 33675749, Free PMC Article
  4. Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly. Yang R, et al. Proc Natl Acad Sci U S A, 2019 Sep 24. PMID 31451636, Free PMC Article
  5. Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling. Garza JC, et al. Transl Psychiatry, 2018 Jul 25. PMID 30046097, Free PMC Article

See all (122) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.
    Title: Abnormal patterns of sleep and waking behaviors are accompanied by neocortical oscillation disturbances in an Ank3 mouse model of epilepsy-bipolar disorder comorbidity.
  2. The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment.
    Title: The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment.
  3. Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na(+) channel.
    Title: Mechanisms and consequences of casein kinase II and ankyrin-3 regulation of the epithelial Na(+) channel.
  4. Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
    Title: Axonal TAU Sorting Requires the C-terminus of TAU but is Independent of ANKG and TRIM46 Enrichment at the AIS.
  5. Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
    Title: Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
  6. Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
    Title: Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.
  7. Results indicate an obligatory role for ankyrin-G protein (AnkG) in lens morphogenesis and growth.
    Title: Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
  8. ANK3 functions in neuronal microtubule dynamics through GSK3 and its downstream substrate CRMP2.
    Title: Disruption of the psychiatric risk gene Ankyrin 3 enhances microtubule dynamics through GSK3/CRMP2 signaling.
  9. Study shows that simultaneous ablation of neuronal Neurofascin and Ankyrin G in young and adult mice reveals age-dependent increase in nodal stability in myelinated axons and differential effects on the lifespan.
    Title: Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.
  10. Results suggested that exon 34 of AnkyrinG is an embryonic-stage-preferential exon that should be excluded from mature neurons and that Elavl3 regulates neuronal polarity through alternative splicing of this exon.
    Title: Elavl3 regulates neuronal polarity through the alternative splicing of an embryo-specific exon in AnkyrinG.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC14049

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphorylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
  
enables structural constituent of cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde axonal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in axon development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to magnesium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clustering of voltage-gated sodium channels ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in magnesium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of protein location in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of delayed rectifier potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in neuronal action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuronal action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of action potential TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane depolarization during cardiac muscle cell action potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to axon IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to axon ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein targeting ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
  
is_active_in axon initial segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon initial segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon initial segment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
  
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in costamere ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in intercalated disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
  
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
 PubMed 
located_in node of Ranvier ISO
Inferred from Sequence Orthology
more info
  
located_in paranode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in spectrin-associated cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ankyrin-3
Names
brain-specific ankyrin-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009670.4 → NP_033800.2  ankyrin-3 isoform g

    See identical proteins and their annotated locations for NP_033800.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) utilizes an alternate exon in the 5' coding region and an alternate translation initiation site, compared to variant 2. This results in a shorter isoform (g) and distinct N-terminus, compared to isoform b.
    Source sequence(s)
    AC132435, L40631
    Consensus CDS
    CCDS59546.1
    UniProtKB/TrEMBL
    S4R1X7
    Related
    ENSMUSP00000138285.2, ENSMUST00000181974.8
    Conserved Domains (2) summary
    smart00218
    Location:116 → 220
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:609 → 692
    Death_ank3; Death domain of Ankyrin-3

  2. NM_146005.3 → NP_666117.2  ankyrin-3 isoform b

    See identical proteins and their annotated locations for NP_666117.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (b).
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    Consensus CDS
    CCDS23909.1
    UniProtKB/Swiss-Prot
    G5E8K4, G5E8K5, O08866, O08867, Q3TSJ8, Q4U205, Q4U206, Q4U256, Q4U260, Q61305, Q61306, Q61307, Q61308, Q61309, Q61310, Q8CBN3, Q8VC68
    Related
    ENSMUSP00000138326.2, ENSMUST00000182884.8
    Conserved Domains (7) summary
    smart00218
    Location:983 → 1087
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1476 → 1559
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  3. NM_170687.3 → NP_733788.2  ankyrin-3 isoform f

    See identical proteins and their annotated locations for NP_733788.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) utilizes an alternate exon in the 5' coding region and an alternate translation initiation site, compared to variant 2. This results in a shorter isoform (f) and distinct N-terminus, compared to isoform b.
    Source sequence(s)
    AC132435, AC156836, L40631
    Consensus CDS
    CCDS23912.1
    UniProtKB/TrEMBL
    S4R236
    Related
    ENSMUSP00000090089.5, ENSMUST00000092433.12
    Conserved Domains (2) summary
    smart00218
    Location:116 → 220
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:609 → 692
    Death_ank3; Death domain of Ankyrin-3

  4. NM_170688.2 → NP_733789.1  ankyrin-3 isoform c

    See identical proteins and their annotated locations for NP_733789.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment in the coding region, compared to variant 2. This results in a shorter isoform (c), compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    UniProtKB/Swiss-Prot
    G5E8K5
    Conserved Domains (7) summary
    smart00218
    Location:983 → 1087
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1476 → 1559
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  5. NM_170689.2 → NP_733790.2  ankyrin-3 isoform d

    See identical proteins and their annotated locations for NP_733790.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter isoform (d), compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    Consensus CDS
    CCDS48590.1
    UniProtKB/TrEMBL
    G5E8K3
    Related
    ENSMUSP00000090088.6, ENSMUST00000092432.12
    Conserved Domains (7) summary
    smart00218
    Location:965 → 1069
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1458 → 1541
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  6. NM_170690.2 → NP_733791.2  ankyrin-3 isoform e

    See identical proteins and their annotated locations for NP_733791.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the coding region, compared to variant 2. This results in a shorter isoform (e), compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    Consensus CDS
    CCDS23910.1
    UniProtKB/TrEMBL
    G5E8K2
    Related
    ENSMUSP00000090087.6, ENSMUST00000092431.12
    Conserved Domains (7) summary
    smart00218
    Location:962 → 1066
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1455 → 1538
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  7. NM_170728.2 → NP_733924.2  ankyrin-3 isoform a

    See identical proteins and their annotated locations for NP_733924.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 2. The encoded isoform (a) is shorter, compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    Consensus CDS
    CCDS59545.1
    UniProtKB/Swiss-Prot
    G5E8K5
    Related
    ENSMUSP00000138347.2, ENSMUST00000182155.8
    Conserved Domains (7) summary
    smart00218
    Location:944 → 1048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1437 → 1520
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  8. NM_170729.2 → NP_733925.2  ankyrin-3 isoform h

    See identical proteins and their annotated locations for NP_733925.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 2. This results in a shorter isoform (h), compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, AC156836, L40632
    Consensus CDS
    CCDS35931.1
    UniProtKB/Swiss-Prot
    G5E8K5
    Related
    ENSMUSP00000061698.9, ENSMUST00000054167.15
    Conserved Domains (7) summary
    smart00218
    Location:944 → 1048
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1437 → 1520
    Death_ank3; Death domain of Ankyrin-3
    cd00204
    Location:443 → 568
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:453 → 544
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:614 → 667
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:732 → 786
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:448 → 479
    ANK; ANK repeat [structural motif]

  9. NM_170730.2 → NP_733926.2  ankyrin-3 isoform i

    See identical proteins and their annotated locations for NP_733926.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an in-frame segment in the 5' coding region and an in-frame segment in the 3' coding region, compared to variant 2. This results in a shorter isoform (i), compared to isoform b.
    Source sequence(s)
    AC129018, AC132435, L40632
    Consensus CDS
    CCDS23911.1
    UniProtKB/TrEMBL
    G3X971, Q9QXH1
    Related
    ENSMUSP00000138356.2, ENSMUST00000182439.8
    Conserved Domains (2) summary
    smart00218
    Location:56 → 160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:549 → 632
    Death_ank3; Death domain of Ankyrin-3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    69234608..69863266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155552.1 → XP_036011445.1  ankyrin-3 isoform X36

    UniProtKB/TrEMBL
    A0A1W2P812
    Related
    ENSMUSP00000151906.2, ENSMUST00000218680.2
    Conserved Domains (7) summary
    smart00218
    Location:976 → 1080
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1469 → 1552
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:363 → 651
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:459 → 490
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1302 → 1431
    UPA_2; UPA domain
    cl39094
    Location:545 → 782
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_036155538.1 → XP_036011431.1  ankyrin-3 isoform X19

    Conserved Domains (7) summary
    smart00218
    Location:966 → 1070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1468 → 1551
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:363 → 651
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:459 → 490
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1292 → 1421
    UPA_2; UPA domain
    cl39094
    Location:545 → 782
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036155553.1 → XP_036011446.1  ankyrin-3 isoform X37

    Conserved Domains (7) summary
    smart00218
    Location:966 → 1070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1468 → 1551
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:363 → 651
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:459 → 490
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1292 → 1421
    UPA_2; UPA domain
    cl39094
    Location:545 → 782
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036155554.1 → XP_036011447.1  ankyrin-3 isoform X38

    Conserved Domains (7) summary
    smart00218
    Location:966 → 1070
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1468 → 1551
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:363 → 651
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:459 → 490
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1292 → 1421
    UPA_2; UPA domain
    cl39094
    Location:545 → 782
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036155557.1 → XP_036011450.1  ankyrin-3 isoform X42

    Conserved Domains (7) summary
    smart00218
    Location:955 → 1059
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1448 → 1531
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:363 → 651
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:459 → 490
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:757 → 809
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1281 → 1410
    UPA_2; UPA domain
    cl39094
    Location:545 → 782
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_036155521.1 → XP_036011414.1  ankyrin-3 isoform X1

    Conserved Domains (9) summary
    smart00218
    Location:1018 → 1155
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:4113 → 4196
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1542 → 1949
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3296 → 3412
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1377 → 1506
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_036155522.1 → XP_036011415.1  ankyrin-3 isoform X2

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:4118 → 4201
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_036155523.1 → XP_036011416.1  ankyrin-3 isoform X3

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:4118 → 4201
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_036155525.1 → XP_036011418.1  ankyrin-3 isoform X5

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:4118 → 4201
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_036155526.1 → XP_036011419.1  ankyrin-3 isoform X6

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:3689 → 3772
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_036155524.1 → XP_036011417.1  ankyrin-3 isoform X4

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:4118 → 4201
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_036155527.1 → XP_036011420.1  ankyrin-3 isoform X7

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:3689 → 3772
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_036155528.1 → XP_036011421.1  ankyrin-3 isoform X8

    Conserved Domains (9) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:3689 → 3772
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam11081
    Location:3301 → 3417
    DUF2890; Protein of unknown function (DUF2890)
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  14. XM_036155529.1 → XP_036011422.1  ankyrin-3 isoform X9

    Conserved Domains (8) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:2408 → 2491
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  15. XM_036155530.1 → XP_036011423.1  ankyrin-3 isoform X10

    Conserved Domains (8) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:2408 → 2491
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1547 → 1954
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  16. XM_036155531.1 → XP_036011424.1  ankyrin-3 isoform X11

    Conserved Domains (8) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:2406 → 2489
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1551 → 1952
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  17. XM_006513133.4 → XP_006513196.1  ankyrin-3 isoform X12

    UniProtKB/TrEMBL
    S4R2K9
    Related
    ENSMUSP00000138686.2, ENSMUST00000182992.8
    Conserved Domains (8) summary
    smart00218
    Location:990 → 1094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:2333 → 2416
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    pfam05109
    Location:1472 → 1879
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1316 → 1445
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  18. XM_036155532.1 → XP_036011425.1  ankyrin-3 isoform X13

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1537 → 1620
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  19. XM_036155540.1 → XP_036011433.1  ankyrin-3 isoform X22

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1558 → 1641
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  20. XM_036155535.1 → XP_036011428.1  ankyrin-3 isoform X16

    Conserved Domains (7) summary
    smart00218
    Location:1012 → 1116
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1493 → 1576
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1338 → 1467
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  21. XM_036155533.1 → XP_036011426.1  ankyrin-3 isoform X14

    Conserved Domains (7) summary
    smart00218
    Location:1008 → 1112
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1501 → 1584
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1334 → 1463
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  22. XM_036155534.1 → XP_036011427.1  ankyrin-3 isoform X15

    Conserved Domains (7) summary
    smart00218
    Location:1001 → 1105
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1494 → 1577
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1327 → 1456
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  23. XM_036155539.1 → XP_036011432.1  ankyrin-3 isoform X21

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1558 → 1641
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  24. XM_036155543.1 → XP_036011436.1  ankyrin-3 isoform X25

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1546 → 1629
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  25. XM_036155542.1 → XP_036011435.1  ankyrin-3 isoform X24

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1549 → 1632
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  26. XM_036155536.1 → XP_036011429.1  ankyrin-3 isoform X17

    Conserved Domains (7) summary
    smart00218
    Location:990 → 1094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1483 → 1566
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1316 → 1445
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  27. XM_036155537.1 → XP_036011430.1  ankyrin-3 isoform X18

    Conserved Domains (7) summary
    smart00218
    Location:980 → 1084
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1473 → 1556
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1306 → 1435
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  28. XM_006513136.4 → XP_006513199.1  ankyrin-3 isoform X20

    Conserved Domains (7) summary
    smart00218
    Location:969 → 1073
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1462 → 1545
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1295 → 1424
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  29. XM_036155541.1 → XP_036011434.1  ankyrin-3 isoform X23

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1549 → 1632
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  30. XM_036155544.1 → XP_036011437.1  ankyrin-3 isoform X26

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1160
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1537 → 1620
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1382 → 1511
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  31. XM_036155545.1 → XP_036011438.1  ankyrin-3 isoform X27

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1127
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1525 → 1608
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1349 → 1478
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  32. XM_036155546.1 → XP_036011439.1  ankyrin-3 isoform X28

    Conserved Domains (7) summary
    smart00218
    Location:1023 → 1127
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1516 → 1599
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1349 → 1478
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  33. XM_036155548.1 → XP_036011441.1  ankyrin-3 isoform X30

    Conserved Domains (7) summary
    smart00218
    Location:1012 → 1116
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1505 → 1588
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1338 → 1467
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  34. XM_036155550.1 → XP_036011443.1  ankyrin-3 isoform X33

    Conserved Domains (7) summary
    smart00218
    Location:980 → 1084
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1482 → 1565
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1306 → 1435
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  35. XM_036155547.1 → XP_036011440.1  ankyrin-3 isoform X29

    Conserved Domains (7) summary
    smart00218
    Location:1012 → 1116
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1505 → 1588
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1338 → 1467
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  36. XM_030244846.2 → XP_030100706.1  ankyrin-3 isoform X31

    Conserved Domains (7) summary
    smart00218
    Location:990 → 1094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1483 → 1566
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1316 → 1445
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  37. XM_036155551.1 → XP_036011444.1  ankyrin-3 isoform X35

    Conserved Domains (7) summary
    smart00218
    Location:990 → 1094
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1471 → 1554
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1316 → 1445
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  38. XM_036155549.1 → XP_036011442.1  ankyrin-3 isoform X32

    Conserved Domains (7) summary
    smart00218
    Location:980 → 1084
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1482 → 1565
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1306 → 1435
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  39. XM_036155556.1 → XP_036011449.1  ankyrin-3 isoform X41

    Conserved Domains (7) summary
    smart00218
    Location:975 → 1079
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1456 → 1539
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1301 → 1430
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  40. XM_017313778.3 → XP_017169267.1  ankyrin-3 isoform X34

    Conserved Domains (7) summary
    smart00218
    Location:982 → 1086
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1475 → 1558
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:369 → 657
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:465 → 496
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763 → 815
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1308 → 1437
    UPA_2; UPA domain
    cl39094
    Location:551 → 788
    Ank_2; Ankyrin repeats (3 copies)

  41. XM_006513138.4 → XP_006513201.1  ankyrin-3 isoform X40

    Conserved Domains (7) summary
    smart00218
    Location:969 → 1073
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1462 → 1545
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:377 → 665
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:473 → 504
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:771 → 823
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1295 → 1424
    UPA_2; UPA domain
    cl39094
    Location:559 → 796
    Ank_2; Ankyrin repeats (3 copies)

  42. XM_036155555.1 → XP_036011448.1  ankyrin-3 isoform X39

    Conserved Domains (7) summary
    smart00218
    Location:972 → 1076
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:1465 → 1548
    Death_ank3; Death domain of Ankyrin-3
    PHA03095
    Location:369 → 657
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:465 → 496
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:763 → 815
    Ank_4; Ankyrin repeats (many copies)
    pfam17809
    Location:1298 → 1427
    UPA_2; UPA domain
    cl39094
    Location:551 → 788
    Ank_2; Ankyrin repeats (3 copies)

  43. XM_006513139.5 → XP_006513202.1  ankyrin-3 isoform X43

    UniProtKB/TrEMBL
    S4R236
    Related
    ENSMUSP00000138337.2, ENSMUST00000182029.8
    Conserved Domains (3) summary
    smart00218
    Location:116 → 220
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    cd08803
    Location:609 → 692
    Death_ank3; Death domain of Ankyrin-3
    pfam17809
    Location:442 → 571
    UPA_2; UPA domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5E8K5.1 GenPept UniProtKB/Swiss-Prot:G5E8K5

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