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Tenm2 teneurin transmembrane protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117242, updated on 11-Apr-2024

Summary

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Symbol
Tenm2provided by RGD
Full Name
teneurin transmembrane protein 2provided by RGD
Primary source
RGD:727907
See related
Ensembl:ENSRNOG00000027341 AllianceGenome:RGD:727907
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Odz2; Lasso
Summary
Enables cell adhesion molecule binding activity and signaling receptor binding activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in dendritic spine and postsynaptic membrane. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane. Orthologous to human TENM2 (teneurin transmembrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 70.7), Adrenal (RPKM 8.4) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
10q12
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (20984710..22121001, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (20480662..21706415, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (20846091..21791771, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480662 Neighboring gene uncharacterized LOC108352202 Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene uncharacterized LOC120095252 Neighboring gene WW and C2 domain containing 1 Neighboring gene uncharacterized LOC108352204 Neighboring gene uncharacterized LOC134480776 Neighboring gene uncharacterized LOC134480777 Neighboring gene uncharacterized LOC120095249 Neighboring gene uncharacterized LOC120095253 Neighboring gene uncharacterized LOC120095250 Neighboring gene uncharacterized LOC108352072 Neighboring gene small nucleolar RNA SNORA72 Neighboring gene uncharacterized LOC134480663

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neurestin: putative transmembrane molecule implicated in neuronal development. Otaki JM, et al. Dev Biol, 1999 Aug 1. PMID 10419693
  2. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities. Silva JP, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21724987, Free PMC Article
  3. All four members of the Ten-m/Odz family of transmembrane proteins form dimers. Feng K, et al. J Biol Chem, 2002 Jul 19. PMID 12000766
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
    Title: Latrophilin 1 and its endogenous ligand Lasso/teneurin-2 form a high-affinity transsynaptic receptor pair with signaling capabilities.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling using intracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in PML body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extrinsic component of postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of postsynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
teneurin-2
Names
neurestin
odd Oz/ten-m homolog 2
odz, odd Oz/ten-m homolog 2
protein Odd Oz/ten-m homolog 2
ten-2
ten-m2
tenascin-M2
teneurin-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020088.1 → NP_064473.1  teneurin-2

    See identical proteins and their annotated locations for NP_064473.1

    Status: PROVISIONAL

    Source sequence(s)
    AF086607
    UniProtKB/TrEMBL
    A6HDJ4
    Conserved Domains (11) summary
    COG3209
    Location:1680 → 2473
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:671 → 700
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1231 → 1270
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2382 → 2459
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:1673 → 1711
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:580 → 602
    EGF_2; EGF-like domain
    pfam15636
    Location:2683 → 2758
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1231 → 1561
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:755 → 796
    DSL; Delta serrate ligand
    cl21470
    Location:923 → 1007
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    20984710..22121001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085070.2 → XP_038940998.1  teneurin-2 isoform X5

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1885 → 2371
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1170 → 1209
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2321 → 2398
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1170 → 1500
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1612 → 1648
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 304
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2620 → 2697
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:500 → 815
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_063268320.1 → XP_063124390.1  teneurin-2 isoform X7

  3. XM_039085069.2 → XP_038940997.1  teneurin-2 isoform X4

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1907 → 2393
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1199 → 1227
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2343 → 2420
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1199 → 1522
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1634 → 1670
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2642 → 2719
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:529 → 844
    exchanger_TraA; outer membrane exchange protein TraA

  4. XM_039085068.2 → XP_038940996.1  teneurin-2 isoform X3

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1914 → 2400
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1199 → 1238
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2350 → 2427
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1199 → 1529
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1641 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2649 → 2726
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:529 → 844
    exchanger_TraA; outer membrane exchange protein TraA

  5. XM_039085071.2 → XP_038940999.1  teneurin-2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5Y1H9, A6HDJ4
    Related
    ENSRNOP00000077386.1
    Conserved Domains (9) summary
    COG3209
    Location:1884 → 2370
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1169 → 1208
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2320 → 2397
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1169 → 1499
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1611 → 1647
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2619 → 2696
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033662
    Location:772 → 802
    acid_disulf_rpt; acidic double-disulfide repeat
    NF033759
    Location:570 → 808
    exchanger_TraA; outer membrane exchange protein TraA

  6. XM_039085066.2 → XP_038940994.1  teneurin-2 isoform X2

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1948 → 2434
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1268
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2384 → 2461
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1563
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1675 → 1711
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2683 → 2760
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  7. XM_039085063.2 → XP_038940991.1  teneurin-2 isoform X1

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    UniProtKB/TrEMBL
    A0A096P6L6
    Conserved Domains (8) summary
    COG3209
    Location:1955 → 2441
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1240 → 1279
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2391 → 2468
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1240 → 1570
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1682 → 1718
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 374
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2690 → 2767
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:570 → 885
    exchanger_TraA; outer membrane exchange protein TraA

  8. XM_063268319.1 → XP_063124389.1  teneurin-2 isoform X1

    UniProtKB/TrEMBL
    A0A096P6L6

  9. XM_039085076.2 → XP_038941004.1  teneurin-2 isoform X12

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1733 → 2219
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1018 → 1057
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2169 → 2246
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1018 → 1348
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1460 → 1496
    RHS_repeat; RHS Repeat
    pfam06484
    Location:14 → 152
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2468 → 2545
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:348 → 663
    exchanger_TraA; outer membrane exchange protein TraA

  10. XM_063268321.1 → XP_063124391.1  teneurin-2 isoform X10

  11. XM_063268322.1 → XP_063124392.1  teneurin-2 isoform X13

  12. XM_039085072.2 → XP_038941000.1  teneurin-2 isoform X8

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1803 → 2289
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1088 → 1127
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2239 → 2316
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1088 → 1418
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1530 → 1566
    RHS_repeat; RHS Repeat
    pfam06484
    Location:10 → 222
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2538 → 2615
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:418 → 733
    exchanger_TraA; outer membrane exchange protein TraA

  13. XM_039085075.2 → XP_038941003.1  teneurin-2 isoform X11

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1758 → 2244
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1043 → 1082
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2194 → 2271
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1043 → 1373
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1485 → 1521
    RHS_repeat; RHS Repeat
    pfam06484
    Location:1 → 177
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2493 → 2570
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:373 → 688
    exchanger_TraA; outer membrane exchange protein TraA

  14. XM_039085074.2 → XP_038941002.1  teneurin-2 isoform X9

    UniProtKB/Swiss-Prot
    Q9R1J9, Q9R1K0, Q9R1K1, Q9R1K2
    Conserved Domains (8) summary
    COG3209
    Location:1793 → 2279
    RhsA; Uncharacterized conserved protein RhsA, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1078 → 1117
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2229 → 2306
    Rhs_assc_core; RHS repeat-associated core domain
    cl18310
    Location:1078 → 1408
    NHL; NHL repeat unit of beta-propeller proteins
    pfam05593
    Location:1520 → 1556
    RHS_repeat; RHS Repeat
    pfam06484
    Location:4 → 212
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2528 → 2605
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    NF033759
    Location:408 → 723
    exchanger_TraA; outer membrane exchange protein TraA
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R1K2.2 GenPept UniProtKB/Swiss-Prot:Q9R1K2

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