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Stk33 serine/threonine kinase 33 [ Mus musculus (house mouse) ]

Gene ID: 117229, updated on 11-Apr-2024

Summary

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Official Symbol
Stk33provided by MGI
Official Full Name
serine/threonine kinase 33provided by MGI
Primary source
MGI:MGI:2152419
See related
Ensembl:ENSMUSG00000031027 AllianceGenome:MGI:2152419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921505G21Rik
Summary
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; heart; lung; sensory organ; and testis. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 30.5) and CNS E11.5 (RPKM 1.6) See more
Orthologs
human all
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Genomic context

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Location:
7 E3; 7 57.21 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (108878270..109038375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109279213..109439168, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:116409223-116409433 Neighboring gene predicted gene, 32563 Neighboring gene predicted gene, 51463 Neighboring gene STARR-seq mESC enhancer starr_19795 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 pseudogene Neighboring gene RIKEN cDNA 1700095J03 gene Neighboring gene tripartite motif-containing 66 Neighboring gene STARR-seq mESC enhancer starr_19797 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis. Yu W, et al. Mol Cell Proteomics, 2023 Jun. PMID 37146716, Free PMC Article
  2. STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells. Zhou M, et al. J Cell Mol Med, 2018 Nov. PMID 30256516, Free PMC Article
  3. Stk33 is required for spermatid differentiation and male fertility in mice. Martins LR, et al. Dev Biol, 2018 Jan 1. PMID 29155043
  4. Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Scholl C, et al. Cell, 2009 May 29. PMID 19490892
  5. Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men. Mujica AO, et al. FEBS J, 2005 Oct. PMID 16176263

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.
    Title: STK33 Phosphorylates Fibrous Sheath Protein AKAP3/4 to Regulate Sperm Flagella Assembly in Spermiogenesis.
  2. he findings from this work indicate that STK33 decreases the sensitivity to the apoptosis dependent on mitochondrial apoptotic pathway by regulating ROS generation after gentamicin treatment, which provides a new potential target for protection from the aminoglycoside-induced ototoxicity.
    Title: STK33 alleviates gentamicin-induced ototoxicity in cochlear hair cells and House Ear Institute-Organ of Corti 1 cells.
  3. Stk33 protein resides in the cytoplasm and partially co-localizes with the caudal end of the manchette, a transient structure that guides tail elongation, in elongating spermatids, and loss of Stk33 leads to the appearance of a tight, straight and elongated manchette.
    Title: Stk33 is required for spermatid differentiation and male fertility in mice.
  4. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity.
    Title: STK33 promotes hepatocellular carcinoma through binding to c-Myc.
  5. Double-immunostaining experiments with antibodies against Stk33 and vimentin showed a striking colocalization of Stk33 and vimentin in the hypothalamus.
    Title: Co-localization of serine/threonine kinase 33 (Stk33) and vimentin in the hypothalamus.
  6. STK33 promotes cancer cell viability in a kinase activity-dependent manner by regulating the suppression of mitochondrial apoptosis mediated through S6K1-induced inactivation of the death agonist BAD selectively in mutant KRAS-dependent cells.
    Title: Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
  7. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group
    Title: Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitotic DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 33
NP_001342074.1
NP_473444.1
XP_006507287.1
XP_006507288.1
XP_006507289.1
XP_006507291.1
XP_006507292.1
XP_011239951.1
XP_011239952.1
XP_011239954.1
XP_017177431.1
XP_017177432.1
XP_030097864.1
XP_030097865.1
XP_036008474.1
XP_036008475.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355145.1 → NP_001342074.1  serine/threonine-protein kinase 33 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124457, AC147221, AC165143
    Consensus CDS
    CCDS90306.1
    UniProtKB/TrEMBL
    A7E1Y3, D3YWA6
    Conserved Domains (1) summary
    cl21453
    Location:1 → 254
    PKc_like; Protein Kinases, catalytic domain

  2. NM_054103.1 → NP_473444.1  serine/threonine-protein kinase 33 isoform 1

    See identical proteins and their annotated locations for NP_473444.1

    Status: VALIDATED

    Source sequence(s)
    AK014819, AW061264, BB614724
    Consensus CDS
    CCDS52358.1
    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000102356.3, ENSMUST00000106745.9
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    108878270..109038375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507224.2 → XP_006507287.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507287.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000112515.2, ENSMUST00000121748.8
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006507226.4 → XP_006507289.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507289.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Related
    ENSMUSP00000087897.5, ENSMUST00000090414.11
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030242005.2 → XP_030097865.1  serine/threonine-protein kinase 33 isoform X5

    UniProtKB/TrEMBL
    A7E1Y3, D3YWA6
    Related
    ENSMUSP00000112560.2, ENSMUST00000121378.2
    Conserved Domains (1) summary
    cl21453
    Location:1 → 254
    PKc_like; Protein Kinases, catalytic domain

  4. XM_036152582.1 → XP_036008475.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030242004.1 → XP_030097864.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    A7E1Y3
    Conserved Domains (1) summary
    cl21453
    Location:72 → 340
    PKc_like; Protein Kinases, catalytic domain

  6. XM_011241652.2 → XP_011239954.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239954.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  7. XM_006507228.4 → XP_006507291.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    A7E1Y3
    Conserved Domains (1) summary
    cl21453
    Location:72 → 340
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017321942.2 → XP_017177431.1  serine/threonine-protein kinase 33 isoform X2

    UniProtKB/TrEMBL
    A7E1Y3
    Conserved Domains (1) summary
    cl21453
    Location:72 → 340
    PKc_like; Protein Kinases, catalytic domain

  9. XM_006507225.4 → XP_006507288.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_006507288.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  10. XM_011241650.3 → XP_011239952.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239952.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  11. XM_011241649.3 → XP_011239951.1  serine/threonine-protein kinase 33 isoform X1

    See identical proteins and their annotated locations for XP_011239951.1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  12. XM_036152581.1 → XP_036008474.1  serine/threonine-protein kinase 33 isoform X1

    UniProtKB/Swiss-Prot
    Q4A1D4, Q924X7
    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

  13. XM_017321943.2 → XP_017177432.1  serine/threonine-protein kinase 33 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:72 → 340
    PKc_like; Protein Kinases, catalytic domain

  14. XM_006507229.4 → XP_006507292.1  serine/threonine-protein kinase 33 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:109 → 377
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003946376.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924X7.2 GenPept UniProtKB/Swiss-Prot:Q924X7

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