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Amy1 amylase 1, salivary [ Mus musculus (house mouse) ]

Gene ID: 11722, updated on 11-Apr-2024

Summary

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Official Symbol
Amy1provided by MGI
Official Full Name
amylase 1, salivaryprovided by MGI
Primary source
MGI:MGI:88019
See related
Ensembl:ENSMUSG00000074264 AllianceGenome:MGI:88019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amy-1; Amy1a; C030014B17Rik
Summary
Enables amylase activity. Acts upstream of or within response to bacterium. Located in extracellular space. Is expressed in several structures, including nervous system; pancreas; and submandibular gland. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 29.9), CNS E18 (RPKM 24.2) and 17 other tissues See more
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Genomic context

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See Amy1 in Genome Data Viewer
Location:
3 F3; 3 49.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113349601..113371399, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113555952..113577750, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2a2 Neighboring gene amylase 2a1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113308015-113308316 Neighboring gene RNA-binding region (RNP1, RRM) containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113332370-113332671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:113332840-113333141 Neighboring gene ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Low Copy Number of the AMY1 Locus Is Associated with Early-Onset Female Obesity in Finland. Viljakainen H, et al. PLoS One, 2015. PMID 26132294, Free PMC Article
  2. Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity. Usher CL, et al. Nat Genet, 2015 Aug. PMID 26098870, Free PMC Article
  3. Multiple polyadenylation sites in a mouse alpha-amylase gene. Tosi M, et al. Nucleic Acids Res, 1981 May 25. PMID 6166922, Free PMC Article
  4. A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs. Young RA, et al. Cell, 1981 Feb. PMID 6162570
  5. Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences. Hagenbüchle O, et al. Nature, 1981 Feb 19. PMID 6162108

See all (102) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Not Applicable (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-amylase activity ISO
Inferred from Sequence Orthology
more info
  
enables amylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cation binding IEA
Inferred from Electronic Annotation
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-amylase 1
Names
1,4-alpha-D-glucan glucanohydrolase 1
alpha-amylase amy1a
salivary and hepatic alpha-amylase
NP_001103975.1
NP_031472.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110505.1 → NP_001103975.1  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_001103975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA616210, BB462169, CK791844, J00356, V00717, V00720
    Consensus CDS
    CCDS17776.1
    UniProtKB/Swiss-Prot
    P00687, Q921Y7
    Related
    ENSMUSP00000070368.6, ENSMUST00000067980.12
    Conserved Domains (3) summary
    cd11317
    Location:25 → 416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422 → 510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46 → 315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

  2. NM_007446.2 → NP_031472.2  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_031472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA616210, BB462169, CK791844, J00356, V00717, V00719
    Consensus CDS
    CCDS17776.1
    UniProtKB/Swiss-Prot
    P00687, Q921Y7
    Related
    ENSMUSP00000102150.2, ENSMUST00000106540.8
    Conserved Domains (3) summary
    cd11317
    Location:25 → 416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422 → 510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46 → 315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    113349601..113371399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00687.2 GenPept UniProtKB/Swiss-Prot:P00687

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