Steap4 STEAP family member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Steap4provided by MGI
Official Full Name: STEAP family member 4provided by MGI
Primary source: MGI:MGI:1923560
See related: Ensembl:ENSMUSG00000012428 AllianceGenome:MGI:1923560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tiarp; Tnfaip9; 1110021O17Rik
Summary: Enables cupric reductase activity and ferric-chelate reductase (NADPH) activity. Acts upstream of or within fat cell differentiation and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in brain. Orthologous to human STEAP4 (STEAP4 metalloreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 70.3), mammary gland adult (RPKM 51.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 A1; 5 3.37 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (8010472..8032213)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (7960472..7982213)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
Title: sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis.
Title: STEAP4 expression in CNS resident cells promotes Th17 cell-induced autoimmune encephalomyelitis.
The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.
Title: The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.
Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.
Title: Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.
IL-17-induced STEAP4-dependent cellular copper uptake is critical for colon tumor formation in a murine model of colitis-associated tumorigenesis and STEAP4 expression correlates with IL-17 level and XIAP activation in human colon cancer.
Title: Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.
data suggest a clear link between ER stress and quantitative and functional STAMP2-deficiency
Title: Inflammation and ER stress differentially regulate STAMP2 expression and localization in adipocytes.
Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE(-/-) /LDLR(-/-) mouse via a PPARgamma/CD36 pathway.
Title: Overexpressing STAMP2 attenuates adipose tissue angiogenesis and insulin resistance in diabetic ApoE(-/-) /LDLR(-/-) mouse via a PPARγ/CD36 pathway.
STEAP4 and mitochondrial iron increased tumor number and burden in a CAC model.
Title: Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer.
hepatic STAMP2 plays a pivotal role in preventing HFD-induced NAFLD and that STAMP2 overexpression improves hepatic steatosis and insulin resistance in NAFLD.
Title: Hepatic STAMP2 alleviates high fat diet-induced hepatic steatosis and insulin resistance.
Data show that high glucose increased protein-protein interaction between Steap4 and S100B in mesangial (MES13) cells.
Title: Steap4 attenuates high glucose and S100B-induced effects in mesangial cells.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables cupric reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cupric reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferric-chelate reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables ferric-chelate reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within copper ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in fat cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within iron import into cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion import across cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within iron ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: metalloreductase STEAP4

Names: Tnfa-induced adipose-related protein; dudulin 4; six-transmembrane epithelial antigen of prostate 4; tumor necrosis factor, alpha-induced protein 9; tumor necrosis factor-alpha-induced adipose-related protein

NP_473439.2

EC 1.16.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_054098.4 → NP_473439.2 metalloreductase STEAP4

See identical proteins and their annotated locations for NP_473439.2

Status: VALIDATED

Source sequence(s)

AC133514

Consensus CDS

CCDS39008.1

UniProtKB/Swiss-Prot

Q91W31, Q91ZE8, Q923B6

Related

ENSMUSP00000111081.2, ENSMUST00000115421.3

Conserved Domains (3) summary

COG2085
Location:24 → 201

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:251 → 318

Ferric_reduct; Ferric reductase like transmembrane component

cl21454
Location:26 → 190

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins