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Rpl6 ribosomal protein L6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117042, updated on 11-Apr-2024

Summary

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Official Symbol
Rpl6provided by RGD
Official Full Name
ribosomal protein L6provided by RGD
Primary source
RGD:619826
See related
Ensembl:ENSRNOG00000025936 AllianceGenome:RGD:619826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 5.8S rRNA binding activity; mRNA binding activity; and tRNA binding activity. Predicted to be involved in cytoplasmic translation and ribosomal large subunit assembly. Located in A band. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 3663.1), Thymus (RPKM 3203.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (41008142..41012756, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35347493..35352011, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40877578..40882032, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S20-like Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family Neighboring gene protein tyrosine phosphatase, non-receptor type 11 Neighboring gene uncharacterized LOC134481334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Separate binding sites on rat liver ribosomal protein L6 for 5 S and 5.8 S ribosomal ribonucleic acids and for transfer ribonucleic acids. Ulbrich N, et al. J Biol Chem, 1982 Oct 10. PMID 7118887
  2. The primary structure of rat ribosomal protein L6. Chan YL, et al. Biochem Mol Biol Int, 1996 Jun. PMID 8828793
  3. Isolation of a cDNA whose expression is markedly increased in malignantly transformed FRTL cells and neoplastic human thyroid tissues. Ohta K, et al. J Mol Endocrinol, 1994 Feb. PMID 8185817
  4. Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1979 Sep 10. PMID 468846
  5. Ribosomal proteins cross-linked to natural mRNA by UV irradiation of rat liver polysomes. Takahashi Y, et al. J Biochem, 1981 Nov. PMID 7338522

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93267

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5.8S rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic translation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL6
Names
60S ribosomal protein L6
neoplasm-related protein C140

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053971.3 → NP_446423.2  large ribosomal subunit protein eL6

    See identical proteins and their annotated locations for NP_446423.2

    Status: PROVISIONAL

    Source sequence(s)
    BC097295
    UniProtKB/Swiss-Prot
    P21533, Q4QRA9, Q64624, Q68G26
    UniProtKB/TrEMBL
    A6J1G1, Q6P790
    Conserved Domains (2) summary
    cd13156
    Location:146 → 298
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:51 → 105
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    41008142..41012756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249378.5 → XP_006249440.1  large ribosomal subunit protein eL6 isoform X2

    See identical proteins and their annotated locations for XP_006249440.1

    UniProtKB/Swiss-Prot
    P21533, Q4QRA9, Q64624, Q68G26
    UniProtKB/TrEMBL
    A6J1G1, Q6P790
    Conserved Domains (2) summary
    cd13156
    Location:146 → 298
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:51 → 105
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  2. XM_039089033.2 → XP_038944961.1  large ribosomal subunit protein eL6 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QIW0
    Related
    ENSRNOP00000038065.6
    Conserved Domains (2) summary
    cd13156
    Location:153 → 305
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:58 → 112
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  3. XM_039089034.2 → XP_038944962.1  large ribosomal subunit protein eL6 isoform X2

    UniProtKB/Swiss-Prot
    P21533, Q4QRA9, Q64624, Q68G26
    UniProtKB/TrEMBL
    A6J1G1, Q6P790
    Conserved Domains (2) summary
    cd13156
    Location:146 → 298
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:51 → 105
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21533.5 GenPept UniProtKB/Swiss-Prot:P21533

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