Amd1 S-adenosylmethionine decarboxylase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amd1provided by MGI
Official Full Name: S-adenosylmethionine decarboxylase 1provided by MGI
Primary source: MGI:MGI:88004
See related: Ensembl:ENSMUSG00000075232 AllianceGenome:MGI:88004
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Amd-1; SAMDC; SAMDC 1; AdoMetDC; adoMetDC1
Summary: Enables adenosylmethionine decarboxylase activity. Acts upstream of or within in utero embryonic development; spermidine biosynthetic process; and spermine biosynthetic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 38.2), liver E14 (RPKM 34.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 21.85 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (40163454..40178184, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (40287458..40302188, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
Title: AMD1 upregulates hepatocellular carcinoma cells stemness by FTO mediated mRNA demethylation.
AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Title: AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.
Amd1 is a major regulator of embryonic stem cell self-renewal and that its essential role lies in its regulation of Myc levels within the cell
Title: AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells.
Embryos lacking the gene were normal at implantation but died before gastrulation.
Title: Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Amd1 (e-PCR), detects polymorphism
- UniSTS:531466

GDB:192496 (e-PCR)
- UniSTS:99316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenosylmethionine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenosylmethionine decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables putrescine binding	IBA Inferred from Biological aspect of Ancestor more info
enables putrescine binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermidine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in spermine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: S-adenosylmethionine decarboxylase proenzyme 1

Names: adoMetDC 1

NP_033795.1

EC 4.1.1.50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.