Stim2 stromal interaction molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Stim2provided by MGI
Official Full Name: stromal interaction molecule 2provided by MGI
Primary source: MGI:MGI:2151156
See related: Ensembl:ENSMUSG00000039156 AllianceGenome:MGI:2151156
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium channel regulator activity; calcium ion binding activity; and store-operated calcium channel activity. Predicted to be involved in activation of store-operated calcium channel activity; cellular calcium ion homeostasis; and store-operated calcium entry. Predicted to act upstream of or within calcium ion transport. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; endocrine gland; and male reproductive gland or organ. Orthologous to human STIM2 (stromal interaction molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 8.3), thymus adult (RPKM 7.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C1; 5 29.69 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (54155865..54278399)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (53998523..54121057)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
Title: Lack of Stim2 Affects Vision-Dependent Behavior and Sensitivity to Hypoxia.
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Title: RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
Title: Calsequestrin 1 Is an Active Partner of Stromal Interaction Molecule 2 in Skeletal Muscle.
Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
Title: Mossy cell synaptic dysfunction causes memory imprecision via miR-128 inhibition of STIM2 in Alzheimer's disease mouse model.
Orai1 inhibitor STIM2beta regulates myogenesis by controlling SOCE dependent transcriptional factors.
Title: Orai1 inhibitor STIM2β regulates myogenesis by controlling SOCE dependent transcriptional factors.
These data indicate that STIM1 and STIM2 have differential roles in the production of IL-4, which are stimulus dependent. Furthermore, these results illustrate the vital role of STIM2 in basophils, which is often considered to be less important than STIM1.
Title: Pivotal role of STIM2, but not STIM1, in IL-4 production by IL-3-stimulated murine basophils.
mice deficient in both Stim1 and Stim2 in T cells (conditional double knockout [cDKO]) developed lymphoproliferative disorders and skin inflammation with a concomitant increase in serum IgG1 and IgE levels.
Title: Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders.
Results indicate that preformed clusters of STIM and ORAI1 enable local Ca(2+) entry events in unstimulated cells. Upon TCR activation, NAADP-evoked Ca(2+) release through RYR1, in coordination with Ca(2+) entry through ORAI1 and STIM, rapidly increases the number of Ca(2+) microdomains, thereby initiating spread of Ca(2+) signals deeper into the cytoplasm to promote full T cell activation.
Title: ORAI1, STIM1/2, and RYR1 shape subsecond Ca(2+) microdomains upon T cell activation.
data show that loss of SOCE in enamel cells has substantial detrimental effects on gene expression, cell function, and the mineralization of dental enamel
Title: Store-operated Ca(2+) entry controls ameloblast cell function and enamel development.
regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes
Title: STIM2 regulates both intracellular Ca(2+) distribution and Ca(2+) movement in skeletal myotubes.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:235180 (e-PCR)
- UniSTS:235180

Stim1 (e-PCR), detects polymorphism
- UniSTS:233960

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stromal interaction molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081103.2 → NP_001074572.2 stromal interaction molecule 2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001074572.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC139037, AK173183, BF472598

Consensus CDS

CCDS39089.2

UniProtKB/Swiss-Prot

P83093, Q69ZI3, Q80VF4

UniProtKB/TrEMBL

A5CVE4, B2RQE3, B7ZN44

Related

ENSMUSP00000113174.3, ENSMUST00000117661.9

Conserved Domains (3) summary

cd09574
Location:132 → 205

SAM_STIM2; SAM domain of STIM2 subfamily proteins

smart00454
Location:133 → 197

SAM; Sterile alpha motif

pfam16533
Location:348 → 445

SOAR; STIM1 Orai1-activating region
NM_001363348.1 → NP_001350277.1 stromal interaction molecule 2 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC139037, AC158152

Consensus CDS

CCDS89921.1

UniProtKB/TrEMBL

B2RQE3, B7ZN44, I1E4X8

Related

ENSMUSP00000143855.2, ENSMUST00000201469.4

Conserved Domains (3) summary

cd09574
Location:132 → 205

SAM_STIM2; SAM domain of STIM2 subfamily proteins

pfam16533
Location:348 → 453

SOAR; STIM1 Orai1-activating region

cl27055
Location:250 → 430

MutS_III; MutS domain III
NM_054083.2 → NP_473424.2 stromal interaction molecule 2 isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC139037, AC158152, AK041804

UniProtKB/TrEMBL

B2RQE3, B7ZN44

Conserved Domains (3) summary

cd09574
Location:132 → 205

SAM_STIM2; SAM domain of STIM2 subfamily proteins

pfam16533
Location:348 → 416

SOAR; STIM1 Orai1-activating region

cl27055
Location:250 → 340

MutS_III; MutS domain III