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Alk anaplastic lymphoma kinase [ Mus musculus (house mouse) ]

Gene ID: 11682, updated on 11-Apr-2024

Summary

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Official Symbol
Alkprovided by MGI
Official Full Name
anaplastic lymphoma kinaseprovided by MGI
Primary source
MGI:MGI:103305
See related
Ensembl:ENSMUSG00000055471 AllianceGenome:MGI:103305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tcrz; CD246
Summary
Predicted to enable identical protein binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in energy homeostasis; negative regulation of lipid catabolic process; and positive regulation of dendrite development. Acts upstream of or within several processes, including hippocampus development; response to environmental enrichment; and swimming behavior. Predicted to be located in axon; cell body; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ALK (ALK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
17 E1.3; 17 43.77 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (72174206..72911719, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (71868988..72604702, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43179 Neighboring gene STARR-seq mESC enhancer starr_43180 Neighboring gene photoreceptor cilium actin regulator Neighboring gene predicted gene, 30140 Neighboring gene CAP-GLY domain containing linker protein family, member 4 Neighboring gene STARR-seq mESC enhancer starr_43182 Neighboring gene predicted gene, 41613 Neighboring gene budding uninhibited by benzimidazoles 3 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_43183 Neighboring gene STARR-seq mESC enhancer starr_43185 Neighboring gene predicted gene, 53975 Neighboring gene STARR-seq mESC enhancer starr_43186 Neighboring gene predicted gene, 53976 Neighboring gene STARR-positive B cell enhancer ABC_E5626 Neighboring gene STARR-seq mESC enhancer starr_43189 Neighboring gene STARR-positive B cell enhancer ABC_E171 Neighboring gene yippee like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ALK-transformed mature T lymphocytes restore early thymus progenitor features. Congras A, et al. J Clin Invest, 2020 Dec 1. PMID 33141118, Free PMC Article
  2. Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice. Kohler H, et al. Thyroid, 2019 Oct. PMID 31526103, Free PMC Article
  3. Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice. Schweitzer P, et al. Neuropharmacology, 2016 Aug. PMID 26946429, Free PMC Article
  4. Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Dutton JW 3rd, et al. Addict Biol, 2017 May. PMID 26752591, Free PMC Article
  5. Targeted Disruption of ALK Reveals a Potential Role in Hypogonadotropic Hypogonadism. Witek B, et al. PLoS One, 2015. PMID 25955180, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
    Title: The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis.
  2. LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
    Title: LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity.
  3. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
    Title: Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation.
  4. Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection.
    Title: Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection.
  5. Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
    Title: Oncogenic ALK (F1174L) drives tumorigenesis in cutaneous squamous cell carcinoma.
  6. A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
    Title: A genome-scale CRISPR screen reveals factors regulating Wnt-dependent renewal of mouse gastric epithelial cells.
  7. ALK-transformed mature T lymphocytes restore early thymus progenitor features.
    Title: ALK-transformed mature T lymphocytes restore early thymus progenitor features.
  8. Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
    Title: Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
  9. Anaplastic lymphoma kinase (ALK) is a novel regulator of NLRP3 inflammasome activation in macrophages. Mechanically, ALK-mediated NF-kappaB activation was required for the priming step of NLRP3 upregulation, whereas ALK-mediated lipid peroxidation contributed to the sensing step of NLRP3-NEK7 complex formation.
    Title: ALK is required for NLRP3 inflammasome activation in macrophages.
  10. NLRR1 appears to be an extracellular negative regulator of ALK signalling in neuroblastoma and neuronal development.
    Title: Neuronal leucine-rich repeat 1 negatively regulates anaplastic lymphoma kinase in neuroblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor signaling protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to environmental enrichment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within swimming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ALK tyrosine kinase receptor
NP_031465.2
XP_036016161.1
XP_036016162.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007439.2 → NP_031465.2  ALK tyrosine kinase receptor precursor

    See identical proteins and their annotated locations for NP_031465.2

    Status: VALIDATED

    Source sequence(s)
    AC154458, AK051358, BE652096, D83002
    Consensus CDS
    CCDS37688.1
    UniProtKB/Swiss-Prot
    E9QKV3, P97793
    Related
    ENSMUSP00000083840.5, ENSMUST00000086639.6
    Conserved Domains (6) summary
    cd06263
    Location:484 → 635
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00192
    Location:445 → 471
    LDLa; Low-density lipoprotein receptor domain class A
    cd05036
    Location:1113 → 1389
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase
    pfam00629
    Location:484 → 640
    MAM; MAM domain, meprin/A5/mu
    pfam07714
    Location:1120 → 1387
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14670
    Location:991 → 1025
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    72174206..72911719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160268.1 → XP_036016161.1  ALK tyrosine kinase receptor isoform X1

    Conserved Domains (2) summary
    PRK12323
    Location:454 → 627
    PRK12323; DNA polymerase III subunit gamma/tau
    cd05036
    Location:160 → 436
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

  2. XM_036160269.1 → XP_036016162.1  ALK tyrosine kinase receptor isoform X2

    Conserved Domains (2) summary
    PRK12323
    Location:431 → 604
    PRK12323; DNA polymerase III subunit gamma/tau
    cd05036
    Location:137 → 413
    PTKc_ALK_LTK; Catalytic domain of the Protein Tyrosine Kinases, Anaplastic Lymphoma Kinase and Leukocyte Tyrosine Kinase

RNA

  1. XR_001782029.3 RNA Sequence

  2. XR_385265.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97793.2 GenPept UniProtKB/Swiss-Prot:P97793

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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