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Aldh3a2 aldehyde dehydrogenase family 3, subfamily A2 [ Mus musculus (house mouse) ]

Gene ID: 11671, updated on 3-Apr-2024

Summary

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Official Symbol
Aldh3a2provided by MGI
Official Full Name
aldehyde dehydrogenase family 3, subfamily A2provided by MGI
Primary source
MGI:MGI:1353452
See related
Ensembl:ENSMUSG00000010025 AllianceGenome:MGI:1353452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ahd3; Ahd-3; Aldh4; FALDH; Ahd-3r; Ahd3-r; Aldh4-r
Summary
Enables aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including hexadecanal metabolic process; nervous system development; and terpenoid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in endoplasmic reticulum. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome. Orthologous to human ALDH3A2 (aldehyde dehydrogenase 3 family member A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 28.8), liver E18 (RPKM 13.6) and 28 other tissues See more
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Genomic context

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See Aldh3a2 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61114240..61158267, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61223417..61267528, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S13, pseudogene 5 Neighboring gene aldehyde dehydrogenase family 3, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E6993 Neighboring gene STARR-seq mESC enhancer starr_29673 Neighboring gene STARR-seq mESC enhancer starr_29674 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61123776-61123977 Neighboring gene solute carrier family 47, member 2 Neighboring gene predicted gene, 25929 Neighboring gene solute carrier family 47, member 1 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neural symptoms in a gene knockout mouse model of Sjögren-Larsson syndrome are associated with a decrease in 2-hydroxygalactosylceramide. Kanetake T, et al. FASEB J, 2019 Jan. PMID 30085884
  2. Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery. Naganuma T, et al. J Biol Chem, 2016 May 27. PMID 27053112, Free PMC Article
  3. Genomic organization, expression, and alternate splicing of the mouse fatty aldehyde dehydrogenase gene. Lin Z, et al. Mol Genet Metab, 2000 Nov. PMID 11073717
  4. Genetics and ontogeny of aldehyde dehydrogenase isozymes in th mouse: evidence for a locus controlling the inducibility of the liver microsomal isozyme. Timms GP, et al. Biochem Genet, 1981 Dec. PMID 7337695
  5. Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome. Nojiri K, et al. Mol Cell Biol, 2021 Sep 24. PMID 34370553, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome.
    Title: Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjögren-Larsson Syndrome.
  2. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
    Title: Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers.
  3. Disruption of the Sjogren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
    Title: Disruption of the Sjögren-Larsson Syndrome Gene Aldh3a2 in Mice Increases Keratinocyte Growth and Retards Skin Barrier Recovery.
  4. FALDH has roles in insulin action and is deregulated in states associated with altered insulin signaling
    Title: Fatty aldehyde dehydrogenase: potential role in oxidative stress protection and regulation of its gene expression by insulin.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-chloroallyl aldehyde dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-chloroallyl aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-alcohol oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain-aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain-aldehyde dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular aldehyde metabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in cellular aldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in formaldehyde metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hexadecanal metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development ISO
Inferred from Sequence Orthology
more info
  
involved_in phytol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in sesquiterpenoid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldehyde dehydrogenase family 3 member A2
Names
alcohol dehydrogenase family 3, subfamily A2
aldehyde dehydrogenase 3
aldehyde dehydrogenase 4, liver microsomal (class 3) regulator
fatty aldehyde dehydrogenase variant form
NP_001318043.1
NP_001318044.1
NP_001404235.1
NP_031463.2
XP_006532093.1
XP_006532094.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331114.2 → NP_001318043.1  aldehyde dehydrogenase family 3 member A2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL672172
    UniProtKB/TrEMBL
    Q99PH4
    Conserved Domains (1) summary
    cd07132
    Location:5 → 444
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  2. NM_001331115.2 → NP_001318044.1  aldehyde dehydrogenase family 3 member A2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL672172
    UniProtKB/TrEMBL
    Q99PH4
    Conserved Domains (1) summary
    cl11961
    Location:1 → 374
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily

  3. NM_001417306.1 → NP_001404235.1  aldehyde dehydrogenase family 3 member A2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672172

  4. NM_007437.6 → NP_031463.2  aldehyde dehydrogenase family 3 member A2 isoform 2

    See identical proteins and their annotated locations for NP_031463.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon resulting in a frameshift, and differs in the 3' UTR. The encoded isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL672172
    Consensus CDS
    CCDS24809.1
    UniProtKB/Swiss-Prot
    P47740, Q99L64
    UniProtKB/TrEMBL
    Q3U7B5, Q8C3C9
    Related
    ENSMUSP00000073764.8, ENSMUST00000074127.14
    Conserved Domains (1) summary
    cd07132
    Location:5 → 444
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RNA

  1. NR_138545.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' exon structure compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL646093, AL672172

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61114240..61158267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532031.5 → XP_006532094.1  aldehyde dehydrogenase family 3 member A2 isoform X2

    UniProtKB/TrEMBL
    Q3U7B5, Q8C3C9
    Conserved Domains (1) summary
    cd07132
    Location:5 → 444
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

  2. XM_006532030.5 → XP_006532093.1  aldehyde dehydrogenase family 3 member A2 isoform X1

    UniProtKB/TrEMBL
    B1AV77, Q8BQ93
    Related
    ENSMUSP00000104355.3, ENSMUST00000108715.3
    Conserved Domains (1) summary
    cd07132
    Location:5 → 444
    ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

RNA

  1. XR_388332.5 RNA Sequence

  2. XR_388331.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47740.2 GenPept UniProtKB/Swiss-Prot:P47740

Gene LinkOut

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