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Fgfrl1 fibroblast growth factor receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 116701, updated on 21-Apr-2024

Summary

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Official Symbol
Fgfrl1provided by MGI
Official Full Name
fibroblast growth factor receptor-like 1provided by MGI
Primary source
MGI:MGI:2150920
See related
Ensembl:ENSMUSG00000008090 AllianceGenome:MGI:2150920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FGFR5; FGFR5beta; FGFR5gamma
Summary
Enables fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within animal organ development; negative regulation of cell population proliferation; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; musculoskeletal system; respiratory system; and sensory organ. Used to study Wolf-Hirschhorn syndrome. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 80.9), genital fat pad adult (RPKM 60.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.24 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108842051..108854816)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108694229..108706950)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene iduronidase, alpha-L Neighboring gene solute carrier family 26 (sulfate transporter), member 1 Neighboring gene predicted gene, 42151 Neighboring gene ring finger protein 212 Neighboring gene RIKEN cDNA 1700047L14 gene Neighboring gene 40S ribosomal protein S8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents. Zhuang L, et al. Comp Biochem Physiol B Biochem Mol Biol, 2015 Aug. PMID 25934085
  2. Keeping it simple: what mouse models of Wolf-Hirschhorn syndrome can tell us about large chromosomal deletions. Abrams JM, et al. Dis Model Mech, 2009 Jul-Aug. PMID 19553686
  3. Expression of FGFRL1, a novel fibroblast growth factor receptor, during embryonic development. Trueb B, et al. Int J Mol Med, 2006 Apr. PMID 16525717
  4. Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for FGFR1 that is up-regulated in beta-cells by cytokine-induced inflammation. Regeenes R, et al. J Biol Chem, 2018 Nov 2. PMID 30217817, Free PMC Article
  5. The FGFRL1 receptor is shed from cell membranes, binds fibroblast growth factors (FGFs), and antagonizes FGF signaling in Xenopus embryos. Steinberg F, et al. J Biol Chem, 2010 Jan 15. PMID 19920134, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dissecting the Interaction of FGF8 with Receptor FGFRL1.
    Title: Dissecting the Interaction of FGF8 with Receptor FGFRL1.
  2. Functional domains of the FgfrL1 receptor.
    Title: Functional domains of the FgfrL1 receptor.
  3. FGFR5 as a co-receptor that is up-regulated by inflammation and promotes FGFR1-induced survival.
    Title: Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for FGFR1 that is up-regulated in beta-cells by cytokine-induced inflammation.
  4. FGFR1 and FGFR2 regulate FGFRL1 expression.
    Title: Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes.
  5. FGFRL1 contains three extracellular Ig-like domains and a single transmembrane domain. It lacks the intracellular tyrosine kinase domain, but contains a short intracellular tail with a peculiar histidine-rich motif.The reason why this motif was conserved during evolution in most species, but not in mice, is not clear.
    Title: Phylogenetic analysis of receptor FgfrL1 shows divergence of the C-terminal end in rodents.
  6. FgfrL1 is specifically required for embryonic development of slow muscle fibers.
    Title: The FgfrL1 receptor is required for development of slow muscle fibers.
  7. Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1.
    Title: Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1.
  8. FGFRL1 does not function as a decoy receptor in beta-cells, but rather it enhances ERK1/2 signaling through association of SHP-1 with the receptor's intracellular SH2-binding motif.
    Title: Fibroblast growth factor receptor like-1 (FGFRL1) interacts with SHP-1 phosphatase at insulin secretory granules and induces beta-cell ERK1/2 protein activation.
  9. The expression profiles of wildtype and Fgfrl1 mutant kidneys, were compared to identify genes that act downstream of Fgfrl1 signaling during the early steps of nephron formation.
    Title: Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.
  10. Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.
    Title: Examination of FGFRL1 as a candidate gene for diaphragmatic defects at chromosome 4p16.3 shows that Fgfrl1 null mice have reduced expression of Tpm3, sarcomere genes and Lrtm1 in the diaphragm.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fibroblast growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fibroblast growth factor receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables non-tyrosine kinase fibroblast growth factor receptor activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within diaphragm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell contact zone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
fibroblast growth factor receptor-like 1
Names
FGF receptor-like protein 1
fibroblast growth factor receptor 5
NP_001157731.1
NP_001412742.1
NP_001412743.1
NP_001412744.1
NP_473412.1
XP_036020635.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164259.2 → NP_001157731.1  fibroblast growth factor receptor-like 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157731.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC123743
    Consensus CDS
    CCDS51592.1
    UniProtKB/Swiss-Prot
    Q91V87
    Related
    ENSMUSP00000108179.4, ENSMUST00000112560.8
    Conserved Domains (3) summary
    cd00096
    Location:151 → 154
    Ig; Ig strand A [structural motif]
    cd05856
    Location:52 → 143
    IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains
    cl11960
    Location:151 → 259
    Ig; Immunoglobulin domain

  2. NM_001425813.1 → NP_001412742.1  fibroblast growth factor receptor-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC123743

  3. NM_001425814.1 → NP_001412743.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC123743
    UniProtKB/Swiss-Prot
    Q91V87, Q920C2, Q920C3

  4. NM_001425815.1 → NP_001412744.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC123743
    UniProtKB/Swiss-Prot
    Q91V87, Q920C2, Q920C3

  5. NM_054071.3 → NP_473412.1  fibroblast growth factor receptor-like 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_473412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC123743
    Consensus CDS
    CCDS19518.1
    UniProtKB/Swiss-Prot
    Q91V87, Q920C2, Q920C3
    Related
    ENSMUSP00000013633.9, ENSMUST00000013633.12
    Conserved Domains (3) summary
    cd05856
    Location:153 → 234
    Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)
    pfam07679
    Location:29 → 112
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:257 → 351
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108842051..108854816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164742.1 → XP_036020635.1  fibroblast growth factor receptor-like 1 isoform X2

    Conserved Domains (3) summary
    cd00096
    Location:151 → 154
    Ig; Ig strand A [structural motif]
    cd05856
    Location:52 → 143
    IgI_2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1); member of the I-set of IgSF domains
    cl11960
    Location:151 → 259
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91V87.1 GenPept UniProtKB/Swiss-Prot:Q91V87

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