Ak4 adenylate kinase 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ak4provided by MGI
Official Full Name: adenylate kinase 4provided by MGI
Primary source: MGI:MGI:87979
See related: Ensembl:ENSMUSG00000028527 AllianceGenome:MGI:87979
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ak3; AK 4; Ak-3; Ak-4; Ak3l1; D4Ertd274e
Summary: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in several processes, including nucleoside phosphate metabolic process; regulation of ATP biosynthetic process; and regulation of oxidative phosphorylation. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 34.8), cerebellum adult (RPKM 9.7) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 46.84 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (101273675..101324968)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (101416478..101467771)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1alpha and AMPK in Macrophages.
Title: Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D85036 (e-PCR)
- UniSTS:163345

D17952 (e-PCR)
- UniSTS:124749

Ak4 (e-PCR), detects polymorphism
- UniSTS:545887

RH126700 (e-PCR)
- UniSTS:167381

RH126799 (e-PCR)
- UniSTS:167385

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleobase-containing compound kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside diphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, phosphate group as acceptor	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in ribonucleoside diphosphate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenylate kinase 4, mitochondrial

Names: ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4, mitochondrial; adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase isoenzyme 4, mitochondrial

NP_001171073.1

EC 2.7.4.10

EC 2.7.4.6

NP_001171075.1

EC 2.7.4.10

EC 2.7.4.6

NP_001171076.1

EC 2.7.4.10

EC 2.7.4.6

NP_033777.1

EC 2.7.4.10

EC 2.7.4.6

XP_006502748.1

EC 2.7.4.10

EC 2.7.4.6

XP_017175412.1

EC 2.7.4.10

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.