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IQCD IQ motif containing D [ Homo sapiens (human) ]

Gene ID: 115811, updated on 5-Mar-2024

Summary

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Official Symbol
IQCDprovided by HGNC
Official Full Name
IQ motif containing Dprovided by HGNC
Primary source
HGNC:HGNC:25168
See related
Ensembl:ENSG00000166578 AllianceGenome:HGNC:25168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRC10; CFAP84; 4933433C09Rik
Summary
Located in ciliary basal body. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 11.7), lung (RPKM 0.8) and 1 other tissue See more
Orthologs
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Genomic context

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Location:
12q24.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (113195446..113221094, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (113172069..113197717, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113633251..113658899, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 73 Neighboring gene microRNA 7106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7062 Neighboring gene DEAD-box helicase 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7063 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:113623217-113623866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113623867-113624517 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113624518-113625167 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113629297-113629950 Neighboring gene Sharpr-MPRA regulatory region 6569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113639865-113640756 Neighboring gene RBPJ interacting and tubulin associated 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7068 Neighboring gene Sharpr-MPRA regulatory region 2606 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24601 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24602 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7069 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7070 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113669293-113669843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7072 Neighboring gene two pore segment channel 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113683649-113684312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113684313-113684976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:113689411-113689911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7073 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24609 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:113705834-113706026 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24611 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24613 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_24616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113736197-113736894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:113736895-113737590 Neighboring gene Sharpr-MPRA regulatory region 468 Neighboring gene NANOG hESC enhancer GRCh37_chr12:113740736-113741469 Neighboring gene microRNA 6762 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:113744904-113746103 Neighboring gene solute carrier family 8 member B1 Neighboring gene MPRA-validated peak1972 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4893

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Chromosome-centric human proteome project: deciphering proteins associated with glioma and neurodegenerative disorders on chromosome 12. Gupta MK, et al. J Proteome Res, 2014 Jul 3. PMID 24804578
  2. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. Bower R, et al. Mol Biol Cell, 2013 Apr. PMID 23427265, Free PMC Article
  3. Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways. Sigg MA, et al. Dev Cell, 2017 Dec 18. PMID 29257953, Free PMC Article
  4. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  5. Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells. Oliviero G, et al. Mol Cell Proteomics, 2016 Nov. PMID 27634302, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein regulatory complex protein 10
Names
IQ domain-containing protein D
dynein regulatory complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330452.2 → NP_001317381.1  dynein regulatory complex protein 10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC089999, AI638678, AK127152, BC013151, CD358970
    Consensus CDS
    CCDS81743.1
    UniProtKB/Swiss-Prot
    Q6ZSU0, Q96DY2
    Related
    ENSP00000400669.2, ENST00000416617.3
    Conserved Domains (1) summary
    COG1196
    Location:212 → 396
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. NM_138451.3 → NP_612460.1  dynein regulatory complex protein 10 isoform 2

    See identical proteins and their annotated locations for NP_612460.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter but has the same N- and C-termini as isoform 1.
    Source sequence(s)
    AK127152, BC013151
    Consensus CDS
    CCDS9167.1
    Related
    ENSP00000299732.2, ENST00000299732.6
    Conserved Domains (1) summary
    cl25732
    Location:101 → 297
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    113195446..113221094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428264.1 → XP_047284220.1  dynein regulatory complex protein 10 isoform X5

  2. XM_005253834.5 → XP_005253891.1  dynein regulatory complex protein 10 isoform X6

    Conserved Domains (1) summary
    COG1196
    Location:56 → 215
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_011537864.3 → XP_011536166.1  dynein regulatory complex protein 10 isoform X3

    Conserved Domains (1) summary
    TIGR02168
    Location:101 → 319
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_047428258.1 → XP_047284214.1  dynein regulatory complex protein 10 isoform X1

  5. XM_047428263.1 → XP_047284219.1  dynein regulatory complex protein 10 isoform X4

  6. XM_047428262.1 → XP_047284218.1  dynein regulatory complex protein 10 isoform X3

  7. XM_047428259.1 → XP_047284215.1  dynein regulatory complex protein 10 isoform X1

  8. XM_005253833.5 → XP_005253890.1  dynein regulatory complex protein 10 isoform X2

    See identical proteins and their annotated locations for XP_005253890.1

    UniProtKB/Swiss-Prot
    Q6ZSU0, Q96DY2
    Conserved Domains (1) summary
    COG1196
    Location:212 → 396
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  9. XM_047428260.1 → XP_047284216.1  dynein regulatory complex protein 10 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    113172069..113197717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371028.1 → XP_054227003.1  dynein regulatory complex protein 10 isoform X5

  2. XM_054371029.1 → XP_054227004.1  dynein regulatory complex protein 10 isoform X6

  3. XM_054371026.1 → XP_054227001.1  dynein regulatory complex protein 10 isoform X3

  4. XM_054371019.1 → XP_054226994.1  dynein regulatory complex protein 10 isoform X1

  5. XM_054371027.1 → XP_054227002.1  dynein regulatory complex protein 10 isoform X4

  6. XM_054371025.1 → XP_054227000.1  dynein regulatory complex protein 10 isoform X3

  7. XM_054371020.1 → XP_054226995.1  dynein regulatory complex protein 10 isoform X1

  8. XM_054371024.1 → XP_054226999.1  dynein regulatory complex protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q6ZSU0, Q96DY2

  9. XM_054371022.1 → XP_054226997.1  dynein regulatory complex protein 10 isoform X1

  10. XM_054371021.1 → XP_054226996.1  dynein regulatory complex protein 10 isoform X1

  11. XM_054371023.1 → XP_054226998.1  dynein regulatory complex protein 10 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DY2.2 GenPept UniProtKB/Swiss-Prot:Q96DY2

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