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TRMT61A tRNA methyltransferase 61A [ Homo sapiens (human) ]

Gene ID: 115708, updated on 11-Apr-2024

Summary

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Official Symbol
TRMT61Aprovided by HGNC
Official Full Name
tRNA methyltransferase 61Aprovided by HGNC
Primary source
HGNC:HGNC:23790
See related
Ensembl:ENSG00000166166 AllianceGenome:HGNC:23790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCD14; TRM61; Gcd14p; hTRM61; C14orf172
Summary
Enables mRNA (adenine-N1-)-methyltransferase activity. Involved in mRNA methylation. Predicted to be located in nucleoplasm. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 4.4), prostate (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

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See TRMT61A in Genome Data Viewer
Location:
14q32.33
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103529196..103537073)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97765240..97773117)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103995533..104003410)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103989409-103990294 Neighboring gene creatine kinase B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103999205-103999704 Neighboring gene uncharacterized LOC124903392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104008443-104009162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104009885-104010606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9105 Neighboring gene RNA, U7 small nuclear 160 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104027599-104028112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6160 Neighboring gene BAG cochaperone 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target. Finer-Moore J, et al. J Mol Biol, 2015 Dec 4. PMID 26470919, Free PMC Article
  2. TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. Macari F, et al. Oncogene, 2016 Apr 7. PMID 26234676
  3. N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Wang Y, et al. Nat Commun, 2021 Nov 2. PMID 34728628, Free PMC Article
  4. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Li X, et al. Mol Cell, 2017 Dec 7. PMID 29107537, Free PMC Article
  5. The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution. Safra M, et al. Nature, 2017 Nov 9. PMID 29072297

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
    Title: N(1)-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism.
  2. we suggest that PKCA tightly controls TRM6/61 activity to prevent translation deregulation that would favor neoplastic development.
    Title: TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis.
  3. The TRM61 heterotetramer is the only active species, both subunits are required for orientating tRNA for catalysis at Trm61.
    Title: Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA(3)(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA (adenine-N1-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA (adenine(58)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of tRNA (m1A) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m1A) methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
Names
mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRM61
tRNA (adenine-N(1)-)-methyltransferase catalytic subunit TRMT61A
tRNA methyltransferase 61 homolog A
tRNA(m1A58)-methyltransferase subunit TRM61
tRNA(m1A58)-methyltransferase subunit TRMT61A
tRNA(m1A58)MTase subunit TRM61
tRNA(m1A58)MTase subunit TRMT61A
NP_689520.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152307.3 → NP_689520.2  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

    See identical proteins and their annotated locations for NP_689520.2

    Status: VALIDATED

    Source sequence(s)
    AL133367, AL139300
    Consensus CDS
    CCDS41994.1
    UniProtKB/Swiss-Prot
    A6NN78, Q8N7Q9, Q96FX7
    Related
    ENSP00000374399.4, ENST00000389749.9
    Conserved Domains (2) summary
    pfam08704
    Location:64 → 286
    GCD14; tRNA methyltransferase complex GCD14 subunit
    pfam14801
    Location:23 → 58
    GCD14_N; tRNA methyltransferase complex GCD14 subunit N-term

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103529196..103537073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97765240..97773117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96FX7.1 GenPept UniProtKB/Swiss-Prot:Q96FX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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