Adra1d adrenergic receptor, alpha 1d [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adra1dprovided by MGI
Official Full Name: adrenergic receptor, alpha 1dprovided by MGI
Primary source: MGI:MGI:106673
See related: Ensembl:ENSMUSG00000027335 AllianceGenome:MGI:106673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spr8; Adra1; Gpcr8; [a]1d; Adra-1; Adra1a; alpha1D-AR
Summary: Enables alpha1-adrenergic receptor activity. Involved in multicellular organism aging; neuron-glial cell signaling; and regulation of blood pressure. Acts upstream of or within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure and norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure. Predicted to be located in cytosol. Predicted to be integral component of plasma membrane. Is expressed in brain; diencephalon; and forebrain. Orthologous to human ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in adrenal adult (RPKM 24.0), cortex adult (RPKM 9.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 63.5 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (131387277..131404417, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (131545357..131562497, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart.
Title: The alpha-1A adrenergic receptor regulates mitochondrial oxidative metabolism in the mouse heart.
the findings of the present study indicate that stimulation of a1 - and b1/2 -ARs markedly reduced serum TG steady-state levels as a result of alterations in TG synthesis, uptake, transport, hydrolysis, metabolism and clearance, an effect induced by PPARa independent mechanisms
Title: Adrenoceptor-related decrease in serum triglycerides is independent of PPARα activation.
no alpha1-AR mRNA was detected in the stroma, and only alpha1B-AR mRNA was found in the Descemet endothelial complex. Remarkably, corneal epithelial thickness and mean epithelial cell size were reduced in alpha1A-AR(-/-) mice. Our findings suggest that the alpha1A-AR exerts growth effects in mouse corneal epithelial cells.
Title: Role of α(1)-adrenoceptor subtypes on corneal epithelial thickness and cell proliferation in mice.
Our results suggest that stimulation of alpha1-ARs results in a favorable metabolic profile of increased glucose tolerance, cardiac glucose uptake, leptin secretion and increased whole body lipid metabolism that may contribute to its previously recognized cardioprotective and neuroprotective benefits.
Title: The role of α(1)-adrenergic receptors in regulating metabolism: increased glucose tolerance, leptin secretion and lipid oxidation.
Erythropoietin seems to reverse sepsis-induced vasoplegia to NE through the preservation of alpha1D adrenoceptor mRNA/protein expression, inhibition of GRK2-mediated desensitization, and attenuation of NO overproduction in the mouse aorta.
Title: Erythropoietin Reverses Sepsis-Induced Vasoplegia to Norepinephrine Through Preservation of α1D-Adrenoceptor mRNA Expression and Inhibition of GRK2-Mediated Desensitization in Mouse Aorta.
The alpha1-AR may play an important role in the development of atrial fibrillation.
Title: Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.
the alpha(1A)-AR subtype mediates adrenergic vasoconstriction in murine ophthalmic arteries.
Title: Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.
investigate the mechanisms involved in the compartmentalization of the PKA-dependent modulation of I(to) in response to alpha1-AR activation.
Title: α1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels.
in mouse ureters: the mRNA for the alpha1A-adrenoceptor was more prevalent than those for the alpha1B- and alpha1D-adrenoceptors
Title: Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter.
Data indicate that alpha1D- and alpha2C-adrenoceptors interact to enhance adrenergic reactivity (norepinephrine-induced constriction) of mesenteric veins but not in mesenteric arteries.
Title: Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC150908P2 (e-PCR)
- UniSTS:271117

PMC150908P3 (e-PCR)
- UniSTS:271118

PMC150908P5 (e-PCR)
- UniSTS:271120

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adrenergic receptor activity	IEA Inferred from Electronic Annotation more info
enables alpha1-adrenergic receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha1-adrenergic receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables alpha1-adrenergic receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron-glial cell signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-1D adrenergic receptor

Names: alpha-1A adrenergic receptor; alpha-1D adrenoceptor; alpha-1D adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013460.5 → NP_038488.4 alpha-1D adrenergic receptor

See identical proteins and their annotated locations for NP_038488.4

Status: VALIDATED

Source sequence(s)

AL831731

Consensus CDS

CCDS16764.1

UniProtKB/Swiss-Prot

P97714, Q61619

UniProtKB/TrEMBL

A2ANQ2

Related

ENSMUSP00000099473.4, ENSMUST00000103184.4

Conserved Domains (2) summary

cd14964
Location:93 → 117

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:91 → 407

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily